Complement Deficiency Treatment & Management

Updated: Feb 18, 2015
  • Author: Ruchir Agrawal, MD; Chief Editor: Russell W Steele, MD  more...
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Treatment

Medical Care

See the list below:

  • No specific treatment is available for genetically acquired complement deficiencies; however, acute attacks of hereditary angioedema (HAE), C1INH deficiency, have been successfully treated with infusion of vapor-heated C1 esterase inhibitor. Androgen therapy can be used to prevent HAE attacks. These treatments are recommended only in adults. A study in the Netherlands indicated efficacy of self-administration of plasma-derived C1INH concentrate for prevention and treatment of angioedema attacks in patients with C1INH deficiency.

  • Only supportive therapy is available for other complement deficiencies. Fresh frozen plasma is used for emergent replacement of complement components.

  • Genes have been cloned for individual component deficiencies. Therefore, gene therapy may be a choice in the future.

  • All routine vaccines are recommended in complement deficiency.

    • Meningococcal vaccine is recommended for children with early or terminal complement component or properdin deficiencies.

    • Pneumococcal vaccine is recommended for deficiency of early components. The effects of influenza plus pneumococcal conjugate vaccination in preventing respiratory tract infections was recently studied.

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Consultations

See the list below:

  • Consultation with a physician who specializes in immunodeficiency disorders may be considered.

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