Pediatric Complement Receptor Deficiency Differential Diagnoses

Updated: Aug 06, 2019
  • Author: Alan P Knutsen, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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DDx

Diagnostic Considerations

The types of infections and infectious microorganisms that occur in leukocyte adhesion deficiency (LAD) type 1 resemble those that occur in patients with neutropenia. Other defects of neutrophils, such as chronic granulomatous disease (CGD) and hyperimmunoglobulin E (HIE) produce similar susceptibility to infections. However, in both CGD and HIE, lymphadenopathy and splenomegaly occur as well as neutrophil inflammatory response to infections.

Differential Diagnoses