Pediatric Complement Receptor Deficiency Follow-up

Updated: Dec 19, 2016
  • Author: Alan P Knutsen, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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Follow-up

Further Outpatient Care

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  • Outpatient intravenous antibiotics, usually through a percutaneous line or central line, can be administered to treat infections.

  • Surgical treatment has been performed when necessary, and the organism has been identified.

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Further Inpatient Care

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  • Inpatient care is required to treat infections in patients with leukocyte adhesion deficiency (LAD), which is caused by complement receptor deficiency.

  • Patients with infections may need surgical drainage, debridement, and intravenous antibiotics.

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Deterrence/Prevention

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  • Education of the parents and patient for early recognition and need for early treatment of infections is essential.

  • Good oral hygiene is important to manage the oral infections (eg, gingivitis, periodontitis).

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Prognosis

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  • The prognosis of patients with the LAD type 1 severe phenotype is poor; these patients require immune reconstitution.

  • Patients with mild and moderate phenotypes of LAD type 1 have infections of decreased severity.

  • CD18 expression of 10% seems to confer protection against invasive life-threatening infections. [9]

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