Pediatric Viral Myocarditis Differential Diagnoses

Updated: Jul 06, 2021
  • Author: Edwin Rodriguez-Cruz, MD; Chief Editor: Howard S Weber, MD, FSCAI  more...
  • Print

Diagnostic Considerations

Myocarditis should be considered in young patients with the following [10] :

  • Apparent cardiovascular conditions that often present as more common cardiac conditions (eg, acute coronary syndrome, acute heart failure)
  • Cardiovascular symptoms but without having typical cardiovascular risk factors and a history of signs/symptoms of recent viral upper respiratory infection or enteroviral infection

Consider fulminant myocarditis in the presence of shock, electric instability, or rapidly evolvig conduction anomalies (eg, widening QRS complex, PR prolongation). [10]  It is also important to recognize the typical signs/symptoms of right heart failure (eg, right upper quadrant pain, anomalies in liver function tests, jaundice, elevated neck veins, peripheral edema, hepatomegaly with liver pulsatility). Differentiate right heart failure early (before progressive cardiogenic shock) from primary hepatobiliary disease (eg, cholecystitis). [10]

Differential diagnosis

Conditions to consider in the differential diagnosis of viral myocarditis include the following:

  • Nonviral myocarditis

  • Viral pericarditis

  • Medial necrosis of the coronary arteries

  • Shock

  • Dilated cardiomyopathy

  • Sepsis [10]

COVID-19 messenger RNA (mRNA) vaccine-related myocarditis

Cases of myocarditis and pericarditis in adolescents and young adults emerged in April 2021, potentially correlated with administration of coronavirus disease 2019 (COVID-19) mRNA vaccines. A case series of seven adolescent males presenting with symptomatic acute myocarditis described similar symptom onset of within a few days (ie, 2-4 days) after vaccine administration, particularly after the second dose. [11] Diagnostic test results were also similar among the patients, including elevated troponin levels, ST elevation, and diffuse myocardial edema. None were critically ill, all responded quickly to treatment with nonsteroidal anti-inflammatories (NSAIDs), and several also received glucocorticoids. [11] A case report of 23 male military members (22 previously healthy) diagnosed with myocarditis within 4 days of receiving an mRNA COVID-19 vaccine has been published. [12] Of these 23 patients, 20 were diagnosed following the second vaccine dose.

A total of 1,226 preliminary myocarditis/pericarditis cases were reported to VAERS (Vaccine Adverse Event Reporting System) following the approximately 300 million mRNA doses administered through June 11, 2021. [13] Most occurred after the second dose, and nearly 80% have been in males. The Centers for Disease Control and Prevention (CDC) and American Academy of Pediatrics (AAP) stress the benefit of the vaccine at preventing severe COVID-19, hospitalization, and death, and they recommend vaccination.

The CDC has published clinical considerations relevant to myocarditis and pericarditis with mRNA COVID-19 vaccines. Instruct patients to seek immediate medical attention if they experience chest pain, dyspnea, or palpitations after receiving the vaccine. Treatment consists of anti-inflammatory agents including NSAIDs, intravenous immunoglobulin (IVIG), and glucocorticoids. Additionally, athletic activity restrictions may be necessary, depending on when serum markers of myocardial injury and inflammation, ventricular systolic function, and clinically relevant arrhythmias return to normal.

The US Food and Drug Administration (FDA) is adding a warning to the fact sheets for the Pfizer/BioNTech and Moderna mRNA COVID-19 vaccines as medical experts continue to investigate cases of heart inflammation. [14]

Differential Diagnoses