Patent Ductus Arteriosus (PDA) Questions & Answers

1. Kaemmerer H, Meisner H, Hess J, Perloff JK. Surgical treatment of patent ductus arteriosus: a new historical perspective. Am J Cardiol. 2004 Nov 1. 94(9):1153-4. [QxMD MEDLINE Link].

2. Cassels DE, Bharati S, Lev M. The natural history of the ductus arteriosus in association with other congenital heart defects. Perspect Biol Med. 1975 Summer. 18(4):541-72. [QxMD MEDLINE Link].

3. Condo M, Evans N, Bellu R, Kluckow M. Echocardiographic assessment of ductal significance: retrospective comparison of two methods. Arch Dis Child Fetal Neonatal Ed. 2012 Jan. 97(1):F35-8. [QxMD MEDLINE Link].

4. Wilson W, Taubert KA, Gewitz M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2007 Oct 9. 116(15):1736-54. [QxMD MEDLINE Link].

5. Vanhaesebrouck S, Zonnenberg I, Vandervoort P, et al. Conservative treatment for patent ductus arteriosus in the preterm. Arch Dis Child Fetal Neonatal Ed. 2007 Jul. 92(4):F244-7. [QxMD MEDLINE Link]. [Full Text].

6. Attridge JT, Kaufman DA, Lim DS. B-type natriuretic peptide concentrations to guide treatment of patent ductus arteriosus. Arch Dis Child Fetal Neonatal Ed. 2009 May. 94(3):F178-82. [QxMD MEDLINE Link].

7. Nuntnarumit P, Chongkongkiat P, Khositseth A. N-terminal-pro-brain natriuretic peptide: a guide for early targeted indomethacin therapy for patent ductus arteriosus in preterm Infants. Acta Paediatr. 2011 Sep. 100(9):1217-21. [QxMD MEDLINE Link].

8. Ohlsson A, Walia R, Shah S. Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants. Cochrane Database Syst Rev. 2008 Jan 23. CD003481. [QxMD MEDLINE Link].

9. Sekar KC, Corff KE. Treatment of patent ductus arteriosus: indomethacin or ibuprofen?. J Perinatol. 2008 May. 28 Suppl 1:S60-2. [QxMD MEDLINE Link].

10. Takami T, Yoda H, Kawakami T, et al. Usefulness of indomethacin for patent ductus arteriosus in full-term infants. Pediatr Cardiol. 2007 Jan-Feb. 28(1):46-50. [QxMD MEDLINE Link].

11. McCarthy JS, Zies LG, Gelband H. Age-dependent closure of the patent ductus arteriosus by indomethacin. Pediatrics. 1978 Nov. 62(5):706-12. [QxMD MEDLINE Link].

12. Watanabe K, Tomita H, Ono Y, Yamada O, Kurosaki K, Echigo S. Intravenous indomethacin therapy in infants with a patent ductus arteriosus complicating other congenital heart defects. Circ J. 2003 Sep. 67(9):750-2. [QxMD MEDLINE Link].

13. Shah SS, Ohlsson A. Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants. Cochrane Database Syst Rev. 2006 Jan 25. CD004213. [QxMD MEDLINE Link].

14. Richards J, Johnson A, Fox G, Campbell M. A second course of ibuprofen is effective in the closure of a clinically significant PDA in ELBW infants. Pediatrics. 2009 Aug. 124(2):e287-93. [QxMD MEDLINE Link].

15. Ohlsson A, Walia R, Shah SS. Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants. Cochrane Database Syst Rev. 2010 Apr 14. 4:CD003481. [QxMD MEDLINE Link].

16. Jones LJ, Craven PD, Attia J, Thakkinstian A, Wright I. Network meta-analysis of indomethacin versus ibuprofen versus placebo for PDA in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2011 Jan. 96(1):F45-52. [QxMD MEDLINE Link].

17. Brion LP, Soll RF. Diuretics for respiratory distress syndrome in preterm infants. Cochrane Database Syst Rev. 2008 Jan 23. CD001454. [QxMD MEDLINE Link].

18. Lin CC, Hsieh KS, Huang TC, Weng KP. Closure of large patent ductus arteriosus in infants. Am J Cardiol. 2009 Mar 15. 103(6):857-61. [QxMD MEDLINE Link].

19. Rapacciuolo A, Losi MA, Borgia F, et al. Transcatheter closure of patent ductus arteriosus reverses left ventricular dysfunction in a septuagenarian. J Cardiovasc Med (Hagerstown). 2009 Apr. 10(4):344-8. [QxMD MEDLINE Link].

20. Chen Z, Chen L, Wu L. Transcatheter amplatzer occlusion and surgical closure of patent ductus arteriosus: comparison of effectiveness and costs in a low-income country. Pediatr Cardiol. 2009 Aug. 30(6):781-5. [QxMD MEDLINE Link].

21. Tomita H, Uemura S, Haneda N, et al. Coil occlusion of PDA in patients younger than 1 year: risk factors for adverse events. J Cardiol. 2009 Apr. 53(2):208-13. [QxMD MEDLINE Link].

22. Hoellering AB, Cooke L. The management of patent ductus arteriosus in Australia and New Zealand. J Paediatr Child Health. 2009 Apr. 45(4):204-9. [QxMD MEDLINE Link].

23. Agnetti A, Carano N, Tchana B, et al. Transcatheter closure of patent ductus arteriosus: experience with a new device. Clin Cardiol. 2009 Nov. 32(11):E71-4. [QxMD MEDLINE Link].

24. Stankowski T, Aboul-Hassan SS, Marczak J, Szymanska A, Augustyn C, Cichon R. Minimally invasive thoracoscopic closure versus thoracotomy in children with patent ductus arteriosus. J Surg Res. 2017 Feb. 208:1-9. [QxMD MEDLINE Link].

25. Vida VL, Lago P, Salvatori S, et al. Is there an optimal timing for surgical ligation of patent ductus arteriosus in preterm infants?. Ann Thorac Surg. 2009 May. 87(5):1509-15; discussion 1515-6. [QxMD MEDLINE Link].

26. Laidman J. Efficacy and risk for PDA ligation uncertain in meta-analysis. Medscape Medical News. Available at http://www.medscape.com/viewarticle/822106. 2014 Mar 17; Accessed: March 23, 2014.

27. Weisz DE, More K, McNamara PJ, et al. PDA ligation and health outcomes: a meta-analysis. Pediatrics. 2014 Apr. 133(4):e1024-46. [QxMD MEDLINE Link].

28. Terlemez S, Isık O, Sahin S, Akcan AB, Kaynak Turkmen M. A rare complication of patent ductus arteriosus ligation: inadvertent ligation of the left pulmonary artery. Heart Surg Forum. 2017 Dec 22. 20(6):E266-E268. [QxMD MEDLINE Link].

29. Heuchan AM, Hunter L, Young D. Outcomes following the surgical ligation of the patent ductus arteriosus in premature infants in Scotland. Arch Dis Child Fetal Neonatal Ed. 2012 Jan. 97(1):F39-44. [QxMD MEDLINE Link].

30. Malviya M, Ohlsson A, Shah S. Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants. Cochrane Database Syst Rev. 2008 Jan 23. CD003951. [QxMD MEDLINE Link].

31. Allegaert K, Rayyan M, Anderson BJ. Impact of ibuprofen administration on renal drug clearance in the first weeks of life. Methods Find Exp Clin Pharmacol. 2006 Oct. 28(8):519-22. [QxMD MEDLINE Link].

32. Burney K, Thayur N, Husain SA, Martin RP, Wilde P. Imaging of implants on chest radiographs: a radiological perspective. Clin Radiol. 2007 Mar. 62(3):204-12. [QxMD MEDLINE Link].

33. Campbell DC, Hood RH Jr, Dooley BN. Patent ductus arteriosus. Review of literature and experience with surgical corrections. J Lancet. 1967 Oct. 87(10):415-8. [QxMD MEDLINE Link].

34. Castaneda A. Congenital heart disease: a surgical-historical perspective. Ann Thorac Surg. 2005 Jun. 79(6):S2217-20. [QxMD MEDLINE Link].

35. Mandhan PL, Samarakkody U, Brown S, et al. Comparison of suture ligation and clip application for the treatment of patent ductus arteriosus in preterm neonates. J Thorac Cardiovasc Surg. 2006 Sep. 132(3):672-4. [QxMD MEDLINE Link].

36. Schneider DJ, Moore JW. Patent ductus arteriosus. Circulation. 2006 Oct 24. 114(17):1873-82. [QxMD MEDLINE Link].

37. Zupancic JA, Richardson DK, O'Brien BJ, et al. Retrospective economic evaluation of a controlled trial of indomethacin prophylaxis for patent ductus arteriosus in premature infants. Early Hum Dev. 2006 Feb. 82(2):97-103. [QxMD MEDLINE Link].

38. de Albuquerque Botura C, da Rocha BA, Balensiefer T, et al. Oral pharmacological treatment for patent ductus arteriosus in premature neonates with hemodynamic repercussions. Asian Pac J Trop Med. 2017 Nov. 10(11):1080-3. [QxMD MEDLINE Link].

39. Agrawal H, Waller BR 3rd, Surendan S, Sathanandam S. New patent ductus arteriosus closure devices and techniques. Interv Cardiol Clin. 2019 Jan. 8(1):23-32. [QxMD MEDLINE Link].

40. Nguyen HL, Phan QT, Doan DD, et al. Percutaneous closure of perimembranous ventricular septal defect using patent ductus arteriosus occluders. PLoS One. 2018. 13(11):e0206535. [QxMD MEDLINE Link]. [Full Text].

41. Hsu KH, Wong P, Subramanyan RK, Evans J, Noori S. Predictors of respiratory improvement 1 week after ligation of patent ductus arteriosus in preterm infants. J Pediatr. 2018 Oct 19. [QxMD MEDLINE Link].

Luke K Kim, MD Assistant Professor of Medicine, Department of Internal Medicine, Division of Cardiology, New York Presbyterian Hospital, Weill Cornell Medical Center

Disclosure: Nothing to disclose.

Jeffrey C Milliken, MD Former Chief, Division of Cardiothoracic Surgery, University of California at Irvine Medical Center; Clinical Professor, Department of Surgery, University of California, Irvine, School of Medicine; Current Professor Emeritus, University of California

Jeffrey C Milliken, MD is a member of the following medical societies: Alpha Omega Alpha, American Association for Thoracic Surgery, American College of Cardiology, American College of Chest Physicians, American College of Surgeons, American Heart Association, American Society for Artificial Internal Organs, California Medical Association, International Society for Heart and Lung Transplantation, Phi Beta Kappa, Society of Thoracic Surgeons, SWOG, Western Surgical Association

Disclosure: Nothing to disclose.

Stuart Berger, MD Executive Director of The Heart Center, Interim Division Chief of Pediatric Cardiology, Lurie Childrens Hospital; Professor, Department of Pediatrics, Northwestern University, The Feinberg School of Medicine

Stuart Berger, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Cardiology, American College of Chest Physicians, American Heart Association, Society for Cardiovascular Angiography and Interventions

Disclosure: Nothing to disclose.

Hugh D Allen, MD Professor, Department of Pediatrics, Division of Pediatric Cardiology and Department of Internal Medicine, Ohio State University College of Medicine

Hugh D Allen, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Cardiology, American Heart Association, American Pediatric Society, American Society of Echocardiography, Society for Pediatric Research, Society of Pediatric Echocardiography, and Western Society for Pediatric Research

Disclosure: Nothing to disclose.

David FM Brown, MD Associate Professor, Division of Emergency Medicine, Harvard Medical School; Vice Chair, Department of Emergency Medicine, Massachusetts General Hospital

David FM Brown, MD is a member of the following medical societies: American College of Emergency Physicians and Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Steven J Compton, MD, FACC, FACP Director of Cardiac Electrophysiology, Alaska Heart Institute, Providence and Alaska Regional Hospitals

Steven J Compton, MD, FACC, FACP is a member of the following medical societies: Alaska State Medical Association, American College of Cardiology, American College of Physicians, American Heart Association, American Medical Association, and Heart Rhythm Society

Disclosure: Nothing to disclose.

Christopher I Doty, MD, FACEP, FAAEM Assistant Professor of Emergency Medicine, Residency Program Director, Department of Emergency Medicine, Kings County Hospital Center, State University of New York Downstate Medical Center

Christopher I Doty, MD, FACEP, FAAEM is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, American Medical Association, Council of Emergency Medicine Residency Directors, and Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Gehaan D'Souza, MD University of California-Irvine School of Medicine

Disclosure: Nothing to disclose.

Justin Galovich, MD Resident Physician, Department of Surgery, University of California, Irvine, School of Medicine

Justin Galovich, MD is a member of the following medical societies: American College of Surgeons

Disclosure: Nothing to disclose.

Christopher Johnsrude, MD, MS Chief, Division of Pediatric Cardiology, University of Louisville School of Medicine; Director, Congenital Heart Center, Kosair Children's Hospital

Christopher Johnsrude, MD, MS is a member of the following medical societies: American Academy of Pediatrics and American College of Cardiology

Disclosure: St Jude Medical Honoraria Speaking and teaching

Steven R Neish, MD, SM Director of Pediatric Cardiology Fellowship Program, Associate Professor, Department of Pediatrics, Baylor College of Medicine

Steven R Neish, MD, SM is a member of the following medical societies: American Academy of Pediatrics, American College of Cardiology, and American Heart Association

Disclosure: Nothing to disclose.

Girish Sethuraman, MD, MPH Assistant Professor, University of Maryland School of Medicine

Girish Sethuraman, MD, MPH is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, American Medical Association, American Public Health Association, and Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Gary Setnik, MD Chair, Department of Emergency Medicine, Mount Auburn Hospital; Assistant Professor, Division of Emergency Medicine, Harvard Medical School

Gary Setnik, MD is a member of the following medical societies: American College of Emergency Physicians, National Association of EMS Physicians, and Society for Academic Emergency Medicine

Disclosure: SironaHealth Salary Management position; South Middlesex EMS Consortium Salary Management position; ProceduresConsult.com Royalty Other

Mark S Slabinski, MD, FACEP, FAAEM Vice President, EMP Medical Group

Mark S Slabinski, MD, FACEP, FAAEM is a member of the following medical societies: Alpha Omega Alpha, American Academy of Emergency Medicine, American College of Emergency Physicians, American Medical Association, and Ohio State Medical Association

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Reference Salary Employment

Park W Willis IV, MD Sarah Graham Distinguished Professor of Medicine and Pediatrics, University of North Carolina at Chapel Hill School of Medicine

Park W Willis IV, MD is a member of the following medical societies: American Society of Echocardiography

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

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