Endocardial Fibroelastosis Differential Diagnoses

Updated: Dec 16, 2020
  • Author: Poothirikovil Venugopalan, MBBS, MD, FRCPCH; Chief Editor: Stuart Berger, MD  more...
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Diagnostic Considerations

Other problems to consider

Other conditions to consider in patients with suspected endocardial fibroelastosis (EFE) include the following:

  • Congenital heart diseases (especially left ventricular [LV] outflow tract obstruction, and anomalous left coronary artery from pulmonary artery) [11]

  • Other causes of nonimmune hydrops fetalis

  • Left ventricular noncompaction

  • Centronuclear myopathy

Important considerations

Identify the disease or to rule out specifically treatable diseases in the differential diagnosis (eg, carnitine deficiency).

Recognize an associated congenital heart disease.

Counsel the parents and caregivers on prognosis.

Avoide premature discontinuation of medication.

Special concerns

Make all possible efforts to detect any treatable cause, such as congenital heart disease or systemic carnitine deficiency.

Risk of endocardial fibroelastosis in subsequent pregnancies is 3-5% and warrants fetal echocardiography for early diagnosis.

Differential Diagnoses