Endocardial Fibroelastosis Medication

Updated: Dec 16, 2020
  • Author: Poothirikovil Venugopalan, MBBS, MD, FRCPCH; Chief Editor: Stuart Berger, MD  more...
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Medication

Medication Summary

If the patient is asymptomatic and his or her heart size is normal, provide early, adequate, and prolonged therapy with digitalis and diuretics for at least 2-3 years, with gradual discontinuation.

Early and prolonged treatment with digoxin is suggested. Anticoagulants may be required in the presence of thromboembolic complications.

Antibiotics for endocarditis prophylaxis are administered to patients with certain cardiac conditions, such as endocardial fibroelastosis, before procedures that may cause bacteremia are performed. For more information, see Antibiotic Prophylactic Regimens for Endocarditis.

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Diuretics

Class Summary

These agents are used to eliminate retained fluid and to lower preload.

Furosemide (Lasix)

Inhibits reabsorption of fluid from ascending limb of Henle loop in renal tubule. IV administration has a venodilator action. Lowers preload even before diuresis sets in. DOC in acute heart failure and in exacerbations of chronic heart failure. Used for long-term management of chronic heart failure.

Spironolactone (Aldactone)

Potassium-sparing diuretic that acts on distal convoluted tubule of kidney as an aldosterone antagonist. Has synergistic action with furosemide.

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ACE inhibitors

Class Summary

These agents reduce afterload and decrease myocardial remodeling, which worsens chronic heart failure.

Captopril (Capoten)

Accepted as an essential part of any antifailure therapy; promotes symptomatic improvement and enhances survival.

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Cardiac glycosides

Class Summary

These agents provide symptomatic improvement.

Digoxin (Lanoxin)

Improves myocardial contractility, reduces heart rate, and lowers sympathetic stimulation in chronic heart failure.

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Oral anticoagulants

Class Summary

These agents prevent recurrence of thromboembolic episodes of cardiac origin.

Warfarin (Coumadin)

Prevents thrombus formation within cardiac chambers and venous circulation by antagonizing effects of vitamin K.

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