Endocardial Fibroelastosis Questions & Answers

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4. Zhang H, Huang X, Liu K, et al. Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium. Cell Res. 2017 Sep. 27 (9):1157-77. [QxMD MEDLINE Link].

5. Graupner O, Enzensberger C, Wieg L, et al. Endocardial fibroelastosis of the left ventricle affects right ventricular performance in fetuses with hypoplastic left heart syndrome: a prospective study using M-mode, PW- and tissue Doppler techniques. Ultraschall Med. 2018 Aug. 39 (4):413-21. [QxMD MEDLINE Link].

6. Arya SO, Karpawich PP, Gupta P, Buddhe S, Singh HR, Hussein Y. Primary endocardial fibroelastosis presenting in a young child as incessant ventricular tachycardia and dilated cardiomyopathy. Tex Heart Inst J. 2012. 39(5):714-8. [QxMD MEDLINE Link].

7. Ni J, Bowles NE, Kim YH, et al. Viral infection of the myocardium in endocardial fibroelastosis. Molecular evidence for the role of mumps virus as an etiologic agent. Circulation. 1997 Jan 7. 95(1):133-9. [QxMD MEDLINE Link]. [Full Text].

8. Chen S, Thompson MW, Rose V. Endocardial fibroelastosis: family studies with special reference to counseling. J Pediatr. 1971 Sep. 79(3):385-92. [QxMD MEDLINE Link].

9. Moller JH, Lucas RV, Adams P, et al. Endocardial fibroelastosis: a clinical and anatomic study of 47 patients with emphasis on its relationship to mitral insufficiency. Circulation. 1964 Nov. 30:759-82. [QxMD MEDLINE Link].

10. Keith JD, Rose V, Manning JA. Endocardial fibroelastosis. Keith JD, Rowe RD, Vlad P, eds. Heart Disease in Infancy and Childhood. 3rd ed. New York, NY: MacMillan; 1978. 941-57.

11. Ma F, Zhou K, Shi X, et al. Misdiagnosed anomalous left coronary artery from the pulmonary artery as endocardial fibroelastosis in infancy: A case series. Medicine (Baltimore). 2017 Jun. 96 (24):e7199. [QxMD MEDLINE Link].

12. Maredia N, English K, Greenwood J. Assessment of endocardial fibroelastosis by cardiac MRI. Can J Cardiol. 2008 May. 24(5):e33. [QxMD MEDLINE Link].

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14. Zhorne D, Petit CJ, Ing FF, Justino H, Jefferies JL, Dreyer WJ. A 25-year experience of endomyocardial biopsy safety in infants. Catheter Cardiovasc Interv. 2013 Nov 1. 82(5):797-801. [QxMD MEDLINE Link].

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17. Al-Ruwaishid A, Vajsar J, Tein I, et al. Centronuclear myopathy and cardiomyopathy requiring heart transplant. Brain Dev. 2003 Jan. 25(1):62-6. [QxMD MEDLINE Link].

18. Angelov A, Kulova A, Gurdevsky M. Endocardial fibroelastosis. Clinico-pathological study of 38 cases. Pathol Res Pract. 1984 Mar. 178(4):384-8. [QxMD MEDLINE Link].

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20. Billingham ME. The safety and utility of endomyocardial biopsy in infants, children and adolescents. J Am Coll Cardiol. 1990 Feb. 15(2):443-5. [QxMD MEDLINE Link].

21. Blieden LC, Schneeweiss A, Deutsch V, Neufeld HN. Contracted form of endocardial fibroelastosis: angiographic diagnosis and necropsy confirmation. Pediatr Cardiol. 1983 Oct-Dec. 4(4):281-3. [QxMD MEDLINE Link].

22. Bovicelli L, Picchio FM, Pilu G, et al. Prenatal diagnosis of endocardial fibroelastosis. Prenat Diagn. 1984 Jan-Feb. 4(1):67-72. [QxMD MEDLINE Link].

23. Brady AN, Shehata BM, Fernhoff PM. X-linked fetal cardiomyopathy caused by a novel mutation in the TAZ gene. Prenat Diagn. 2006 May. 26(5):462-5. [QxMD MEDLINE Link].

24. Burke A, Mont E, Kutys R, Virmani R. Left ventricular noncompaction: a pathological study of 14 cases. Hum Pathol. 2005 Apr. 36(4):403-11. [QxMD MEDLINE Link].

25. Buyon JP, Rupel A, Clancy RM. Neonatal lupus syndromes. Lupus. 2004. 13(9):705-12. [QxMD MEDLINE Link].

26. Calabrese F, Rigo E, Milanesi O, et al. Molecular diagnosis of myocarditis and dilated cardiomyopathy in children: clinicopathologic features and prognostic implications. Diagn Mol Pathol. 2002 Dec. 11(4):212-21. [QxMD MEDLINE Link].

27. Carceller AM, Maroto E, Fouron JC. Dilated and contracted forms of primary endocardial fibroelastosis: a single fetal disease with two stages of development. Br Heart J. 1990 May. 63(5):311-3. [QxMD MEDLINE Link].

28. Carrasco Guerra HA, Palacios-Pru E, Dagert de Scorza C, et al. Clinical, histochemical, and ultrastructural correlation in septal endomyocardial biopsies from chronic chagasic patients: detection of early myocardial damage. Am Heart J. 1987 Mar. 113(3):716-24. [QxMD MEDLINE Link].

29. Chang AC, Huhta JC, Yoon GY, et al. Diagnosis, transport, and outcome in fetuses with left ventricular outflow tract obstruction. J Thorac Cardiovasc Surg. 1991 Dec. 102(6):841-8. [QxMD MEDLINE Link].

30. Chen SC, Balfour IC, Jureidini S. Clinical spectrum of restrictive cardiomyopathy in children. J Heart Lung Transplant. 2001 Jan. 20(1):90-2. [QxMD MEDLINE Link].

31. Dajani AS, Taubert KA, Wilson W, et al. Prevention of bacterial endocarditis. Recommendations by the American Heart Association. JAMA. 1997 Jun 11. 277(22):1794-801. [QxMD MEDLINE Link].

32. Edwards JE. Functional pathology of congenital cardiac disease. Pediatr Clin North Am. 1954 Feb. 25:13-49. [QxMD MEDLINE Link].

33. Fishbein MC, Ferrans VJ, Roberts WC. Histologic and ultrastructural features of primary and secondary endocardial fibroelastosis. Arch Pathol Lab Med. 1977 Jan. 101(1):49-54. [QxMD MEDLINE Link].

34. Fuchs U, Zittermann A, Schulz U, et al. Unusual case of an 18-year-old heart transplant recipient with endocardial fibroelastosis. Transplant Proc. 2006 Jun. 38(5):1511-3. [QxMD MEDLINE Link].

35. Greenwood RD, Nadas AS, Fyler DC. The clinical course of primary myocardial disease in infants and children. Am Heart J. 1976 Nov. 92(5):549-60. [QxMD MEDLINE Link].

36. Harris LC, Nghiem QX. Cardiomyopathies in infants and children. Prog Cardiovasc Dis. 1972 Nov-Dec. 15(3):255-87. [QxMD MEDLINE Link].

37. Hunter AS, Keay AJ. Primary endocardial fibroelastosis. An inherited condition. Arch Dis Child. 1973 Jan. 48(1):66-9. [QxMD MEDLINE Link].

38. Hutchins GM, Vie SA. The progression of interstitial myocarditis to idiopathic endocardial fibroelastosis. Am J Pathol. 1972 Mar. 66(3):483-96. [QxMD MEDLINE Link].

39. Iida M, Inamura N, Takeuchi M. Newborn infant with maternal anti-SSA antibody-induced complete heart block accompanying cardiomyopathy. Circ J. 2006 Jan. 70(1):147-9. [QxMD MEDLINE Link].

40. Ino T, Benson LN, Freedom RM, Rowe RD. Natural history and prognostic risk factors in endocardial fibroelastosis. Am J Cardiol. 1988 Sep 1. 62(7):431-4. [QxMD MEDLINE Link].

41. Ito T, Sasaki T, Ono I. Secondary endocardial fibroelastosis associated with Pompe disease and multicystic dysplastic kidney. Heart Vessels. 2000. 15(5):240-2. [QxMD MEDLINE Link].

42. Jayaprasad N, Johnson F, Venugopal K. Congenital complete heart block and maternal connective tissue disease. Int J Cardiol. 2006 Sep 20. 112(2):153-8. [QxMD MEDLINE Link].

43. Kamisago M, Schmitt JP, McNamara D, Seidman C, Seidman JG. Sarcomere protein gene mutations and inherited heart disease: a beta-cardiac myosin heavy chain mutation causing endocardial fibroelastosis and heart failure. Novartis Found Symp. 2006. 274:176-89; discussion 189-95, 272-6. [QxMD MEDLINE Link].

44. Katcher ML, Segar WE, Wolfson JJ, et al. Clinicopathologic conference: a six-month-old infant with sudden onset of metabolic acidosis and shock. Am J Med Genet. 1982 Jan. 11(1):77-96. [QxMD MEDLINE Link].

45. Knirsch W, Mehwald P, Dittrich S, Kececioglu D. [Restrictive cardiomyopathy in childhood]. Z Kardiol. 2004 Jul. 93(7):566-73. [QxMD MEDLINE Link].

46. Leatherbury L, Chandra RS, Shapiro SR, Perry LW. Value of endomyocardial biopsy in infants, children and adolescents with dilated or hypertrophic cardiomyopathy and myocarditis. J Am Coll Cardiol. 1988 Dec. 12(6):1547-54. [QxMD MEDLINE Link].

47. Lee LA. Neonatal lupus: clinical features and management. Paediatr Drugs. 2004. 6(2):71-8. [QxMD MEDLINE Link].

48. Lurie PR. Endocardial fibroelastosis is not a disease. Am J Cardiol. 1988 Sep 1. 62(7):468-70. [QxMD MEDLINE Link].

49. McElhinney DB, Lock JE, Keane JF, et al. Left heart growth, function, and reintervention after balloon aortic valvuloplasty for neonatal aortic stenosis. Circulation. 2005 Feb 1. 111(4):451-8. [QxMD MEDLINE Link]. [Full Text].

50. Mitchell SC, Froehlich LA, Banas JS, Gilkeson MR. An epidemiologic assessment of primary endocardial fibroelastosis. Am J Cardiol. 1966 Dec. 18(6):859-66. [QxMD MEDLINE Link].

51. Nield LE, Silverman ED, Smallhorn JF, et al. Endocardial fibroelastosis associated with maternal anti-Ro and anti-La antibodies in the absence of atrioventricular block. J Am Coll Cardiol. 2002 Aug 21. 40(4):796-802. [QxMD MEDLINE Link].

52. Nield LE, Silverman ED, Taylor GP, et al. Maternal anti-Ro and anti-La antibody-associated endocardial fibroelastosis. Circulation. 2002 Feb 19. 105(7):843-8. [QxMD MEDLINE Link].

53. Piercecchi-Marti MD, Mohamed H, Chau C, et al. Congenital atrioventricular block: histological aspects. Forensic Sci Int. 2003 Sep 9. 136(1-3):12-5. [QxMD MEDLINE Link].

54. Raboisson MJ, Fouron JC, Sonesson SE, et al. Fetal Doppler echocardiographic diagnosis and successful steroid therapy of Luciani-Wenckebach phenomenon and endocardial fibroelastosis related to maternal anti-Ro and anti-La antibodies. J Am Soc Echocardiogr. 2005 Apr. 18(4):375-80. [QxMD MEDLINE Link].

55. Rodriguez MM, Bruce JH, Jimenez XF, et al. Nonimmune hydrops fetalis in the liveborn: series of 32 autopsies. Pediatr Dev Pathol. 2005 May-Jun. 8(3):369-78. [QxMD MEDLINE Link].

56. Rodriguez MM, Bruce JH, Jimenez XF, et al. Nonimmune hydrops fetalis in the liveborn: series of 32 autopsies. Pediatr Dev Pathol. 2005 May-Jun. 8(3):369-78. [QxMD MEDLINE Link].

57. Schindler E, Muller M, Akinturk H, et al. Perioperative management in pediatric heart transplantation from 1988 to 2001: anesthetic experience in a single center. Pediatr Transplant. 2004 Jun. 8(3):237-42. [QxMD MEDLINE Link].

58. Schmid C, Debus V, Gogarten W, et al. Pediatric assist with the Medos and Excor systems in small children. ASAIO J. 2006 Sep-Oct. 52(5):505-8. [QxMD MEDLINE Link].

59. Schmider A, Henrich W, Dahnert I, Dudenhausen JW. Prenatal therapy of non-immunologic hydrops fetalis caused by severe aortic stenosis. Ultrasound Obstet Gynecol. 2000 Sep. 16(3):275-8. [QxMD MEDLINE Link].

60. Schryer MJ, Karnauchow PN. Endocardial fibroelastosis; etiologic and pathogenetic considerations in children. Am Heart J. 1974 Nov. 88(5):557-65. [QxMD MEDLINE Link].

61. Sjoberg G, Chow CW, Cooper S, Weintraub RG. X-linked cardiomyopathy presenting as contracted endocardial fibroelastosis. J Heart Lung Transplant. 2007 Mar. 26(3):293-5. [QxMD MEDLINE Link].

62. Tingelstad JB, Shiel FO, McCue CM. The elctrocardiogram in the contracted type of primary endocardial fibroelastosis. Am J Cardiol. 1971 Mar. 27(3):304-8. [QxMD MEDLINE Link].

63. Tworetzky W, del Nido PJ, Powell AJ, et al. Usefulness of magnetic resonance imaging of left ventricular endocardial fibroelastosis in infants after fetal intervention for aortic valve stenosis. Am J Cardiol. 2005 Dec 1. 96(11):1568-70. [QxMD MEDLINE Link].

64. Ursell PC, Neill CA, Anderson RH, et al. Endocardial fibroelastosis and hypoplasia of the left ventricle in neonates without significant aortic stenosis. Br Heart J. 1984 May. 51(5):492-7. [QxMD MEDLINE Link].

65. Valdes-Dapena M, Gilbert-Barness E. Cardiovascular causes for sudden infant death. Pediatr Pathol Mol Med. 2002 Mar-Apr. 21(2):195-211. [QxMD MEDLINE Link].

66. Van Buchem FSP, Arends A, Schroeder EA. Endocardial fibroelastosis in adolescents and young adults. Br Heart J. 1959. 21:229-237.

67. Van der Hauwaert LG, Denef B, Dumoulin M. Long-term echocardiographic assessment of dilated cardiomyopathy in children. Am J Cardiol. 1983 Nov 1. 52(8):1066-71. [QxMD MEDLINE Link].

68. Veille JC, Sivakoff M. Fetal echocardiographic signs of congenital endocardial fibroelastosis. Obstet Gynecol. 1988 Aug. 72(2):219-22. [QxMD MEDLINE Link].

69. Vida VL, Bottio T, Milanesi O, et al. Critical aortic stenosis in early infancy: surgical treatment for residual lesions after balloon dilation. Ann Thorac Surg. 2005 Jan. 79(1):47-51; discussion 51-2. [QxMD MEDLINE Link].

70. Wang IJ, Chen SJ, Wang JK, et al. Electron beam computed tomography appearance of endocardial fibroelastosis EBCT appearance of endocardial fibroelastosis. Int J Cardiovasc Imaging. 2003 Feb. 19(1):85-90. [QxMD MEDLINE Link].

71. Westwood M, Harris R, Burn JL, Barson AJ. Heredity in primary endocardial fibroelastosis. Br Heart J. 1975 Oct. 37(10):1077-84. [QxMD MEDLINE Link].

72. Wloch A, Respondek-Liberska M, Sysa A, et al. [Significant aortic valve stenosis in the prenatal period--diagnosis, treatment, outcome. Two-center study]. Przegl Lek. 2004. 61(6):589-92. [QxMD MEDLINE Link].

73. Yinon Y, Yagel S, Hegesh J, et al. Fetal cardiomyopathy--in utero evaluation and clinical significance. Prenat Diagn. 2007 Jan. 27(1):23-8. [QxMD MEDLINE Link].

74. Yoshizato T, Edwards WD, Alboliras ET, et al. Safety and utility of endomyocardial biopsy in infants, children and adolescents: a review of 66 procedures in 53 patients. J Am Coll Cardiol. 1990 Feb. 15(2):436-42. [QxMD MEDLINE Link].

75. Zhang N, Hu Q, Li Y, Liu J, Xu L, Sun Z. Spontaneous interventricular septum dissecting hematoma with endocardial fibroelastosis: imaging, diagnosis, surgical therapy and 6-year follow-up outcomes. Quant Imaging Med Surg. 2020 Apr. 10 (4):878-82. [QxMD MEDLINE Link]. [Full Text].

Poothirikovil Venugopalan, MBBS, MD, FRCPCH Consultant Pediatrician with Cardiology Expertise, Department of Child Health, Brighton and Sussex University Hospitals, NHS Trust; Honorary Senior Clinical Lecturer, Brighton and Sussex Medical School, UK

Poothirikovil Venugopalan, MBBS, MD, FRCPCH is a member of the following medical societies: British Congenital Cardiac Association, Paediatrician with Cardiology Expertise Special Interest Group, Royal College of Paediatrics and Child Health

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Julian M Stewart, MD, PhD Associate Chairman of Pediatrics, Director, Center for Hypotension, Westchester Medical Center; Professor of Pediatrics and Physiology, New York Medical College

Julian M Stewart, MD, PhD is a member of the following medical societies: American Academy of Pediatrics, American Autonomic Society, American Physiological Society

Disclosure: Received research grant from: Lundbeck Pharmaceuticals<br/>Received grant/research funds from Lundbeck Pharmaceuticals for none.

Stuart Berger, MD Executive Director of The Heart Center, Interim Division Chief of Pediatric Cardiology, Lurie Childrens Hospital; Professor, Department of Pediatrics, Northwestern University, The Feinberg School of Medicine

Stuart Berger, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Cardiology, American College of Chest Physicians, American Heart Association, Society for Cardiovascular Angiography and Interventions

Disclosure: Nothing to disclose.

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