Pediatric Fungal Endocarditis Differential Diagnoses

1. Kubota K, Soma K, Uehara M, et al. Combined surgical and medical therapy for candida prosthetic endocarditis in a patient with repaired tetralogy of Fallot. Int Heart J. 2018 Jul 31. 59(4):877-80. [QxMD MEDLINE Link]. [Full Text].

2. Marom D, Levy I, Gutwein O, Birk E, Ashkenazi S. Healthcare-associated versus community-associated infective endocarditis in children. Pediatr Infect Dis J. 2011 Jul. 30(7):585-8. [QxMD MEDLINE Link].

3. Pasha AK, Lee JZ, Low SW, Desai H, Lee KS, Al Mohajer M. Fungal endocarditis: update on diagnosis and management. Am J Med. 2016 Oct. 129(10):1037-43. [QxMD MEDLINE Link].

4. Gupta S, Sakhuja A, McGrath E, Asmar B. Trends, microbiology, and outcomes of infective endocarditis in children during 2000-2010 in the United States. Congenit Heart Dis. 2017 Mar. 12(2):196-201. [QxMD MEDLINE Link].

5. Kara A, Devrim I, Mese T, Bayram N, Yılmazer M, Gulfidan G. The frequency of infective endocarditis in Candida bloodstream infections: a retrospective study in a child hospital. Braz J Cardiovasc Surg. 2018 Jan-Feb. 33(1):54-8. [QxMD MEDLINE Link]. [Full Text].

6. Benjamin DK, Miro JM, Hoen B, et al. Candida endocarditis: contemporary cases from the International Collaboration of Infectious Endocarditis Merged Database (ICE-mD). Scand J Infect Dis. 2004. 36(6-7):453-5. [QxMD MEDLINE Link].

7. Blum MD, Wiedermann BL. Aspergillus infections. In: Fletcher J, ed. Textbook of Pediatric Infectious Diseases. Philadelphia, Pa: WB Saunders; 1998. 2288-96.

8. Nikolousis E, Velangi M. Two cases of aspergillus endocarditis in non neutropenic children on chemotherapy for acute lymphoblastic leukaemia. Hematol Rep. 2011 Jan 13. 3(1):e7. [QxMD MEDLINE Link]. [Full Text].

9. Alhaji M, Sadikot RT. Cryptococcal endocarditis. South Med J. 2011 May. 104(5):363-4. [QxMD MEDLINE Link].

10. Ahmad S, Zia S, Sarwari AR. Scedosporium prolificans endocarditis: case report and review of literature. W V Med J. 2010 Sep-Oct. 106(6):24-6. [QxMD MEDLINE Link].

11. Ferrieri P, Gewitz MH, Gerber MA, et al. Unique features of infective endocarditis in childhood. Pediatrics. 2002 May. 109(5):931-43. [QxMD MEDLINE Link]. [Full Text].

12. Ganesan V, Ponnusamy SS, Sundaramurthy R. Fungal endocarditis in paediatrics: a review of 192 cases (1971-2016). Cardiol Young. 2017 Oct. 27(8):1481-7. [QxMD MEDLINE Link].

13. Chen J, Li J, Zhou T, et al. Contemporary in-hospital and long-term outcomes of surgical management for fungal endocarditis. Int Heart J. 2017 Aug 3. 58(4):516-20. [QxMD MEDLINE Link]. [Full Text].

14. Kuhn C, Disque C, Muhl H, Orszag P, Stiesch M, Haverich A. Evaluation of commercial universal rRNA gene PCR plus sequencing tests for identification of bacteria and fungi associated with infectious endocarditis. J Clin Microbiol. 2011 Aug. 49(8):2919-23. [QxMD MEDLINE Link]. [Full Text].

15. Marcano Sanz L, Naranjo Ugalde A, Gonzalez Guillen A, Bermudez Gutierrez G, Frias Griskho F. [Infective fungal endocarditis in patients with no previous cardiac disease] [Spanish]. An Pediatr (Barc). 2013 Feb. 78(2):113-7. [QxMD MEDLINE Link].

16. Russell HM, Johnson SL, Wurlitzer KC, Backer CL. Outcomes of surgical therapy for infective endocarditis in a pediatric population: a 21-year review. Ann Thorac Surg. 2013 Jul. 96(1):171-4: discussion 174-5. [QxMD MEDLINE Link].

17. Smego RA Jr, Ahmad H. The role of fluconazole in the treatment of Candida endocarditis: a meta-analysis. Medicine (Baltimore). 2011 Jul. 90(4):237-49. [QxMD MEDLINE Link].

18. Kaufman D, Boyle R, Hazen KC, et al. Fluconazole prophylaxis against fungal colonization and infection in preterm infants. N Engl J Med. 2001 Dec 6. 345(23):1660-6. [QxMD MEDLINE Link].

19. Ankola PA, Perveen S, Fish B. Fungal endocarditis. J Perinatol. 2006 Aug. 26(8):509-10. [QxMD MEDLINE Link].

20. Baddley JW, Benjamin DK Jr, Patel M, et al. Candida infective endocarditis. Eur J Clin Microbiol Infect Dis. 2008 Jul. 27(7):519-29. [QxMD MEDLINE Link]. [Full Text].

21. Baghaei R, Moghaddam MY, Shahidi M. An unusual right atrial mass in a two-month old infant. Cardiol Young. 2007 Dec. 17(6):673-4. [QxMD MEDLINE Link].

22. Baltimore RS. Infective endocarditis. In: Jenson HB, Baltimore RS, eds. Pediatric Infectious Diseases: Principles and Practice. 2nd ed. Norwalk: Appleton & Lange; 2002. 845-56.

23. Benjamin DK Jr, Stoll BJ, Gantz MG, et al, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Neonatal candidiasis: epidemiology, risk factors, and clinical judgment. Pediatrics. 2010 Oct. 126(4):e865-73. [QxMD MEDLINE Link]. [Full Text].

24. Biel MA. Photodynamic therapy of bacterial and fungal biofilm infections. Methods Mol Biol. 2010. 635:175-94. [QxMD MEDLINE Link].

25. Chopra T, Bhargava A, Kumar S, et al. Candida kefyr endocarditis in a patient with hypertrophic obstructive cardiomyopathy. Am J Med Sci. 2010 Feb. 339(2):188-9. [QxMD MEDLINE Link].

26. Davutoglu V, Ercan S, Tekbas E. Cardiac aspergillosis: endocardial or endomyocardial?. Int J Infect Dis. 2011 Sep. 15(9):e653. [QxMD MEDLINE Link].

27. Day MD, Gauvreau K, Shulman S, Newburger JW. Characteristics of children hospitalized with infective endocarditis. Circulation. 2009 Feb 17. 119(6):865-70. [QxMD MEDLINE Link].

28. Divekar A, Rebekya IM, Soni R. Late onset Candida parapsilosis endocarditis after surviving nosocomial candidemia in an infant with structural heart disease. Pediatr Infect Dis J. 2004 May. 23(5):472-5. [QxMD MEDLINE Link].

29. Ellis ME, Al-Abdely H, Sandridge A, et al. Fungal endocarditis: evidence in the world literature, 1965-1995. Clin Infect Dis. 2001 Jan. 32(1):50-62. [QxMD MEDLINE Link].

30. Falcone M, Barzaghi N, Carosi G, et al. Candida infective endocarditis: report of 15 cases from a prospective multicenter study. Medicine (Baltimore). 2009 May. 88(3):160-8. [QxMD MEDLINE Link].

31. Garcia-Teresa MA, Casado-Flores J, Delgado Dominguez MA, et al. Infectious complications of percutaneous central venous catheterization in pediatric patients: a Spanish multicenter study. Intensive Care Med. 2007 Mar. 33(3):466-76. [QxMD MEDLINE Link].

32. Grizelj R, Vukovic J, Saric D, Luetic T. Giant mycotic right atrial thrombus due to Candida dubliniensis septicemia in a premature infant. Pediatr Infect Dis J. 2010 Aug. 29(8):785-6. [QxMD MEDLINE Link].

33. Guzman-Cottrill JA, Zheng X, Chadwick EG. Fusarium solani endocarditis successfully treated with liposomal amphotericin B and voriconazole. Pediatr Infect Dis J. 2004 Nov. 23(11):1059-61. [QxMD MEDLINE Link].

34. Hallum JL, Williams TW Jr. Candida endocarditis. In: Bodey GP, ed. Candidiasis: Pathogenesis, Diagnosis, and Treatment. 2nd ed. New York: Raven Press; 1993. 357-69.

35. Hughes WT, Flynn PM. Candidiasis. In: Fletcher J, ed. Textbook of Pediatric Infectious Diseases. 4th ed. Philadelphia, Pa: WB Saunders; 1998. 2303-13.

36. Johnson JA, Boyce TG, Cetta F, Steckelberg JM, Johnson JN. Infective endocarditis in the pediatric patient: a 60-year single-institution review. Mayo Clin Proc. 2012 Jul. 87(7):629-35. [QxMD MEDLINE Link]. [Full Text].

37. Karatza AA, Dimitriou G, Marangos M, et al. Successful resolution of cardiac mycetomas by combined liposomal Amphotericin B with Fluconazole treatment in premature neonates. Eur J Pediatr. 2008 Sep. 167(9):1021-3. [QxMD MEDLINE Link].

38. Kawasaki Y, Matsubara K, Ishihara H, et al. Corynebacterium propinquum as the first cause of infective endocarditis in childhood. J Infect Chemother. 2014 May. 20(5):317-9. [QxMD MEDLINE Link].

39. Kothari A, Pillai BS, Bhan A. Pacing lead endocarditis due to Aspergillus fumigatus. Indian J Med Microbiol. 2010 Jan-Mar. 28(1):72-3. [QxMD MEDLINE Link].

40. La Via WV, Koulouri S, Ross LA, et al. Right atrial mass in a child with disseminated coccidioidomycosis. Pediatr Infect Dis J. 2005 May. 24(5):470-2. [QxMD MEDLINE Link].

41. Lefort A, Chartier L, Sendid B, et al. Diagnosis, management and outcome of Candida endocarditis. Clin Microbiol Infect. 2012 Apr. 18(4):E99-E109. [QxMD MEDLINE Link]. [Full Text].

42. Levy I, Shalit I, Askenazi S, et al. Duration and outcome of persistent candidaemia in newborn infants. Mycoses. 2006 May. 49(3):197-201. [QxMD MEDLINE Link].

43. Levy I, Shalit I, Birk E, et al. Candida endocarditis in neonates: report of five cases and review of the literature. Mycoses. 2006 Jan. 49(1):43-8. [QxMD MEDLINE Link].

44. Luciani GB, Casali G, Viscardi F, et al. Tricuspid valve repair in an infant with multiple obstructive Candida mycetomas. Ann Thorac Surg. 2005 Dec. 80(6):2378-81. [QxMD MEDLINE Link].

45. Marodi L, Johnston RB Jr. Invasive Candida species disease in infants and children: occurrence, risk factors, management, and innate host defense mechanisms. Curr Opin Pediatr. 2007 Dec. 19(6):693-7. [QxMD MEDLINE Link].

46. Mayayo E, Moralejo J, Camps J, Guarro J. Fungal endocarditis in premature infants: case report and review. Clin Infect Dis. 1996 Feb. 22(2):366-8. [QxMD MEDLINE Link].

47. Millar BC, Jugo J, Moore JE. Fungal endocarditis in neonates and children. Pediatr Cardiol. 2005 Sep-Oct. 26(5):517-36. [QxMD MEDLINE Link].

48. Mitchell ME, McManus M, Dietz J, Camitta BM, Szabo S, Havens P. Absidia corymbifera endocarditis: survival after treatment of disseminated mucormycosis with radical resection of tricuspid valve and right ventricular free wall. J Thorac Cardiovasc Surg. 2010 Apr. 139(4):e71-2. [QxMD MEDLINE Link]. [Full Text].

49. Moreno-Martinez FL, Lopez FH, Bermudez R, et al. A case report of fungal mitral-valve endocarditis. MedGenMed. 2003 Jan 28. 5(1):9. [QxMD MEDLINE Link].

50. Mrowczynski W, Wojtalik M. Caspofungin for Candida endocarditis. Pediatr Infect Dis J. 2004 Apr. 23(4):376. [QxMD MEDLINE Link].

51. Nadir E, Rubinstein E. Fungal endocarditis. Curr Infect Dis Rep. 2004 Aug. 6(4):276-82. [QxMD MEDLINE Link].

52. Nemoto H, Nomura R, Ooshima T, Nakano K. Distribution of amoxicillin-resistant oral streptococci in dental plaque specimens obtained from Japanese children and adolescents at risk for infective endocarditis. J Cardiol. 2013 Nov. 62(5):296-300. [QxMD MEDLINE Link].

53. Noyola DE, Fernandez M, Moylett EH, Baker CJ. Ophthalmologic, visceral, and cardiac involvement in neonates with candidemia. Clin Infect Dis. 2001 Apr 1. 32(7):1018-23. [QxMD MEDLINE Link].

54. Odio CM, Araya R, Pinto LE, et al. Caspofungin therapy of neonates with invasive candidiasis. Pediatr Infect Dis J. 2004 Dec. 23(12):1093-7. [QxMD MEDLINE Link].

55. Overturf GD. Focal bacterial infections. IN: Remington JS, Klein JO, eds. Infectious Diseases of the Fetus and Newborn Infant. 6th ed. Philadelphia, Pa: WB Saunders; 2006. 347-84.

56. Ozkiraz S, Tarcan A, Gokmen Z, et al. Invasive Candida albicans infection mimicking leukemia in a neonate. J Matern Fetal Neonatal Med. 2007 Jul. 20(7):555-7. [QxMD MEDLINE Link].

57. Pai MP, Samples ML, Mercier RC, Spilde MN. Activities and ultrastructural effects of antifungal combinations against simulated Candida endocardial vegetations. Antimicrob Agents Chemother. 2008 Jul. 52(7):2367-76. [QxMD MEDLINE Link].

58. Palomares JC, Bernal S, Marin M, et al. Molecular diagnosis of Aspergillus fumigatus endocarditis. Diagn Microbiol Infect Dis. 2011 Aug. 70(4):534-7. [QxMD MEDLINE Link].

59. Philippe B, Grenet D, Honderlick P, et al. Severe Aspergillus endocarditis in a lung transplant recipient with a five-year survival. Transpl Infect Dis. 2010 Jun. 12(3):273-6. [QxMD MEDLINE Link].

60. Robertson J, Shilkofski N. Drug doses. In: The Harriet Lane Handbook: A Manual for Pediatric House Officers. 17th ed. Philadelphia, PA: Mosby; 2005. 679-1009.

61. Rodriguez D, Almirante B, Park BJ, et al. Candidemia in neonatal intensive care units: Barcelona, Spain. Pediatr Infect Dis J. 2006 Mar. 25(3):224-9. [QxMD MEDLINE Link].

62. Sanchez PJ, Siegel JD, Fishbein J. Candida endocarditis: successful medical management in three preterm infants and review of the literature. Pediatr Infect Dis J. 1991 Mar. 10(3):239-43. [QxMD MEDLINE Link].

63. Starke JR. Infective endocarditis. In: Fletcher J, ed. Textbook of Pediatric Infectious Diseases. 4th ed. Philadelphia, Pa: WB Saunders; 1998. 315-38.

64. Steinbach WJ, Benjamin DK. New antifungal agents under development in children and neonates. Curr Opin Infect Dis. 2005 Dec. 18(6):484-9. [QxMD MEDLINE Link].

65. Steinbach WJ, Perfect JR, Cabell CH, et al. A meta-analysis of medical versus surgical therapy for Candida endocarditis. J Infect. 2005 Oct. 51(3):230-47. [QxMD MEDLINE Link].

66. Talarmin JP, Boutoille D, Tattevin P, et al. Candida endocarditis: role of new antifungal agents. Mycoses. 2009 Jan. 52(1):60-6. [QxMD MEDLINE Link].

67. Tissieres P, Jaeggi ET, Beghetti M, Gervaix A. Increase of fungal endocarditis in children. Infection. 2005 Aug. 33(4):267-72. [QxMD MEDLINE Link].

68. Tolan RW, Kleiman MB, Frank M, et al. Operative intervention in active endocarditis in children: report of a series of cases and review. Clin Infect Dis. 1992 Apr. 14(4):852-62. [QxMD MEDLINE Link].

69. Varghese GM, Sobel JD. Fungal endocarditis. Curr Infect Dis Rep. 2008 Jul. 10(4):275-9. [QxMD MEDLINE Link].

70. Weinstein L, Brusch JL. Microbiology of infective endocarditis and clinical correlates: gram-negative and other organisms. In: Infective Endocarditis. New York: Oxford University Press; 1996. 73-122.

71. Weinstein L, Brusch JL. Pediatric endocarditis. In: Infective Endocarditis. New York: Oxford University Press; 1996. 229-35.

72. Wertz KK, Pretzlaff RK. Caspofungin in a pediatric patient with persistent candidemia. Pediatr Crit Care Med. 2004 Mar. 5(2):181-3. [QxMD MEDLINE Link].

73. Wong CW, Porter G, Tisch J, Young C. Outcome and prognostic factors on 57 cases of infective endocarditis in a single centre. N Z Med J. 2009 Oct 9. 122(1304):54-62. [QxMD MEDLINE Link].

74. Yellapu RK, Mittal V, Grewal P. Education and Imaging. Hepatobiliary and pancreatic: Candida liver abscesses associated with endocarditis. J Gastroenterol Hepatol. 2010 May. 25(5):1017. [QxMD MEDLINE Link].

75. Pradegan N, Munoz YM, Reyes M, Toribio J, Herrera CJ, Leon-Wyss JR. Giant right atrial abscess in a premature infant with fungal endocarditis in a developing country. World J Pediatr Congenit Heart Surg. 2020 Sep. 11(5):654-7. [QxMD MEDLINE Link].

Sandy N Shah, DO, MBA, FACC, FACP, FACOI Cardiologist

Sandy N Shah, DO, MBA, FACC, FACP, FACOI is a member of the following medical societies: American College of Cardiology, American College of Osteopathic Internists, American College of Physicians, American Medical Association, American Osteopathic Association, American Society of Nuclear Cardiology, Society for Cardiovascular Angiography and Interventions

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Julian M Stewart, MD, PhD Associate Chairman of Pediatrics, Director, Center for Hypotension, Westchester Medical Center; Professor of Pediatrics and Physiology, New York Medical College

Julian M Stewart, MD, PhD is a member of the following medical societies: American Academy of Pediatrics, American Autonomic Society, American Physiological Society

Disclosure: Received research grant from: Lundbeck Pharmaceuticals<br/>Received grant/research funds from Lundbeck Pharmaceuticals for none.

Syamasundar Rao Patnana, MD Professor of Pediatrics and Medicine, Division of Cardiology, Emeritus Chief of Pediatric Cardiology, University of Texas Medical School at Houston and Children's Memorial Hermann Hospital

Syamasundar Rao Patnana, MD is a member of the following medical societies: American Academy of Pediatrics, American Pediatric Society, American College of Cardiology, American Heart Association, Society for Cardiovascular Angiography and Interventions, Society for Pediatric Research

Disclosure: Nothing to disclose.

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