Double Orifice Mitral Valve Differential Diagnoses

Updated: May 10, 2021
  • Author: Georgios A Hartas, MD, FACC, FSCAI, FAAP; Chief Editor: Stuart Berger, MD  more...
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Diagnostic Considerations

Other problems to be considered

Other conditions to consider in the differential diagnosis of double orifice mitral valve (DOMV) include the following:

  • Associated congenital heart disease - Atrioventricular (AV) septal defect, ventricular septal defect (VSD), left sided cardiac lesions

  • Syndromes and conditions - Trisomy 21, de Lange syndrome, Astrom syndrome, Kabuki syndrome, and isovaleric academia

Important considerations

It is important to identify double orifice mitral valve as the cause of mitral valve obstruction or regurgitation or as an associated defect in patients with atrioventricular-canal defect and other congenital heart diseases (CHDs).

Identify and recognize associated abnormalities of the mitral valve apparatus in patients with DOMV.

Special concerns

Double orifice mitral valve may not be detected easily in children with CHDs; therefore, awareness of the problem and careful echocardiographic screening are important in all children with mitral valve disease.

Differential Diagnoses