Gianotti-Crosti Syndrome Workup

Updated: Apr 14, 2017
  • Author: Sören A Craig-Müller, MD; Chief Editor: Dirk M Elston, MD  more...
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Workup

Laboratory Studies

In general, no laboratory studies are needed in patients with Gianotti-Crosti syndrome (GCS). Jaundice or hepatomegaly should prompt a search for the hepatitis B virus and elevated levels of liver enzymes. However, elevated levels of liver enzymes are most likely related to Epstein-Barr virus infection.

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Procedures

A skin biopsy may be performed to rule out other diseases in the differential diagnosis.

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Histologic Findings

Skin biopsy findings are nonspecific and are more helpful in ruling out other diseases. The epidermis shows focal spongiosis, parakeratosis, mild acanthosis, and psoriasiform epidermal hyperplasia. [3]  The upper dermis has a moderately intense perivascular infiltrate of lymphocytes and histiocytes with occasional scattered eosinophils. [15] Extravasated erythrocytes can be found in the papillary dermis. [6]

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