Childhood-Onset Schizophrenia Differential Diagnoses

Updated: Mar 25, 2019
  • Author: Marshal E Ash, DO; Chief Editor: Caroly Pataki, MD  more...
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Diagnostic Considerations

The diagnosis of schizophrenia requires the exclusion of mood disorders with psychotic features (bipolar disorder), substance-induced psychotic disorder, and psychosis due to a medical condition. The following conditions should be considered when evaluating a child or adolescent with suspected schizophrenia:

  • Psychosis secondary to epilepsy; psychosis not otherwise specified; and psychosis, single episode

  • Neurodegenerative disorders

  • Central nervous system (CNS) tumor

  • Progressive organic CNS disorder (eg, sclerosing panencephalitis)

  • Schizoaffective disorder

Chromosomal disorder: 22q11 deletion syndrome

Differential Diagnoses