Pediatric Arginine Vasopressin Disorders (Diabetes Insipidus) Treatment & Management

Updated: Aug 24, 2023
  • Author: Karl S Roth, MD; Chief Editor: Robert P Hoffman, MD  more...
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Approach Considerations

Infants ingest relatively large amounts of low renal solute load fluids, either as breast milk or formula, and have a relatively high-volume of dilute urine output to maintain sodium/water homeostasis. In arginine vasopressin (AVP) disorders (diabetes insipidus), increased fluid turnover is managed by increased free water intake and/or decreased urine output.

Treat patients with an AVP disorder in an inpatient setting because of the risk of severe dehydration. Destructive or compressive intracranial lesions mandate inpatient stay. Demonstration of an intracranial mass necessitates surgical care.

Distinguishing between central and nephrogenic etiologies is essential to treatment. [28] Transfer to an academic center is very strongly advised for initial diagnosis and treatment, especially because AVP deficiency (AVP-D) (central diabetes insipidus) may require involved diagnostic studies and neurosurgical or oncologic treatment. Surgical procedures of any kind require replacement of fluids at a much higher rate than normal maintenance; inattention to this may result in serious consequences.

Subsequent admissions are determined by the need for intravenous rehydration, especially during intercurrent gastrointestinal illnesses.

Treatment regimens currently in use have recently been reviewed. [29]


Pharmacologic Therapy

For arginine vasopressin deficiency (AVP-D) (central diabetes insipidus), the treatment of choice is desmopressin (a synthetic vasopressin analogue). It is available in parenteral, intranasal, and oral dosage forms. The doses widely vary depending on the preparation used, so care must be taken to correctly calculate the dose. Other useful medications include chlorpropamide and thiazide diuretics, [30] which can result in a 25-75% reduction in urine volume and can be used in combination with each other.

AVP resistance (AVP-R) (nephrogenic diabetes insipidus) cannot be effectively treated with desmopressin, because the receptor sites are defective and the kidney is prevented from responding. Thiazide diuretics, amiloride, [31, 32] and indomethacin or aspirin are useful when coupled with a low-solute diet. This approach does not normalize urine output and continues to necessitate increased oral fluid intake.

Aqueous vasopressin and desmopressin preparations are available for intravenous use in emergency circumstances. Overtreatment with desmopressin can result in hyponatremia and seizures. Subcutaneous, intranasal, or oral tablet desmopressin therapy is challenging for caregivers to titrate in a dose appropriate for infants. In one study, dilute intranasal desmopressin administered buccally was found to be a safe treatment alternative for AVP-R in infancy. [33] Mavinkurve et al detailed the oral use of diluted nasal desmopressin in treatment of a neonate with AVP-D. [34]


Diet and Activity

Provide infants with arginine vasopressin (AVP) disorders (diabetes insipidus) with a breast milk diet to decrease solute load. Protein should account for 6% of caloric intake, and sodium should be reduced to 0.7 mEq/kg/day.

Provide young children with 8% of their caloric intake in the form of protein to enable normal growth. Sodium intake must be maintained at 0.7 mEq/kg/day. (See the video below.)

Pediatric Arginine Vasopressin Disorders (Diabetes Insipidus). Carbs for Kids-Count Them In: The Constant Carbohydrates Diet.

Activities resulting in increased insensible water loss should be moderated in the presence of massive urinary water loss to prevent dehydration. Heat exposure should be minimized, especially when participating in sports. Avoid creating barriers to drinking water.


Consultations and Long-Term Monitoring

Consultation with the following specialists may be appropriate:

  • Nephrologist

  • Endocrinologist: The presence of AVP deficiency (AVP-D) (central diabetes insipidus) should prompt an evaluation of anterior pituitary function

  • Diagnostic radiologist

Regular follow-up visits with an endocrinologist (for AVP-D) or a nephrologist (for AVP resistance [AVP-R]) (nephrogenic diabetes insipidus) are necessary for dosage adjustment. When indomethacin is used in long-term therapy, carefully observe renal function for any signs of toxicity.