Hyperpituitarism Questions & Answers

Updated: Jun 30, 2020
  • Author: Alicia Diaz-Thomas, MD, MPH; Chief Editor: Robert P Hoffman, MD  more...
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Questions & Answers

Overview

What is hyperpituitarism?

What is the pathophysiology of hyperpituitarism?

What is the role of prolactinoma in the pathophysiology of hyperpituitarism?

What is the role of corticotropinoma (Cushing disease) in the pathophysiology of hyperpituitarism?

What is the role of somatotropinoma (gigantism) in the pathophysiology of hyperpituitarism?

What is the role of thyrotropinoma in the pathophysiology of hyperpituitarism?

What is the prevalence of hyperpituitarism in the US?

What is the morbidity associated with hyperpituitarism?

What are the racial predilections of hyperpituitarism?

What are the sexual predilections of hyperpituitarism?

Which age groups have the highest prevalence of hyperpituitarism?

What is the prognosis of hyperpituitarism?

Presentation

What are the signs and symptoms of hyperpituitarism?

Which clinical history findings are characteristic of excess prolactin in hyperpituitarism?

Which clinical history findings are characteristic of excess adrenocorticotropic hormone in hyperpituitarism?

Which clinical history findings are characteristic of excess growth hormone in hyperpituitarism?

Which physical findings are characteristic of hyperpituitarism?

Which physical findings are characteristic of prolactinoma are characteristic of hyperpituitarism?

Which physical findings are characteristic of Cushing disease in hyperpituitarism?

Which physical findings are characteristic of gigantism in hyperpituitarism?

What causes hyperpituitarism?

DDX

Which conditions are included in the differential diagnoses of hyperpituitarism?

What are the differential diagnoses for Hyperpituitarism?

Workup

Which lab tests are performed to assess hyperprolactinemia in hyperpituitarism?

Which lab tests are performed to assess growth hormone–releasing adenoma in hyperpituitarism?

Which lab tests are performed to assess adrenocorticotropic hormone–releasing adenoma in hyperpituitarism?

What is the role of imaging studies in the workup of hyperpituitarism?

Treatment

How is prolactinoma treated in hyperpituitarism?

How is corticotropinoma treated in hyperpituitarism?

How is somatotropinoma treated in hyperpituitarism?

What is the role of surgery in the treatment of hyperpituitarism?

Which specialist consultations are beneficial to patients with hyperpituitarism?

What is included in the long-term monitoring of hyperpituitarism?

Medications

Which medications in the drug class Anticonvulsants are used in the treatment of Hyperpituitarism?

Which medications in the drug class Antifungals, imidazoles are used in the treatment of Hyperpituitarism?

Which medications in the drug class Diagnostics are used in the treatment of Hyperpituitarism?

Which medications in the drug class Growth hormone receptor antagonists are used in the treatment of Hyperpituitarism?

Which medications in the drug class Somatostatin analogs are used in the treatment of Hyperpituitarism?

Which medications in the drug class Dopamine agonists are used in the treatment of Hyperpituitarism?