Pediatric Hypoglycemia Questions & Answers

1. Rozance PJ, Hay WW Jr. New approaches to management of neonatal hypoglycemia. Matern Health Neonatol Perinatol. 2016 May 10. 2:3. [QxMD MEDLINE Link]. [Full Text].

2. Abramowski A, Ward R, Hamdan AH. Neonatal Hypoglycemia. StatPearls. 2021 Jan. [QxMD MEDLINE Link]. [Full Text].

3. Demirbilek H, Rahman SA, Buyukyilmaz GG, Hussain K. Diagnosis and treatment of hyperinsulinaemic hypoglycaemia and its implications for paediatric endocrinology. Int J Pediatr Endocrinol. 2017. 2017:9. [QxMD MEDLINE Link]. [Full Text].

4. de Lonlay P, Giurgea I, Sempoux C, Touati G, Jaubert F, Rahier J, et al. Dominantly inherited hyperinsulinaemic hypoglycaemia. J Inherit Metab Dis. 2005. 28(3):267-76. [QxMD MEDLINE Link].

5. Di Candia S, Gessi A, Pepe G, et al. Identification of a diffuse form of hyperinsulinemic hypoglycemia by 18-fluoro-L-3,4 dihydroxyphenylalanine positron emission tomography/CT in a patient carrying a novel mutation of the HADH gene. Eur J Endocrinol. 2009 Jun. 160(6):1019-23. [QxMD MEDLINE Link].

6. Hoe FM, Thornton PS, Wanner LA, et al. Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism. J Pediatr. 2006 Feb. 148(2):207-12. [QxMD MEDLINE Link].

7. Zigron R, Rotem R, Erlichman I, et al. Factors associated with the development of neonatal hypoglycemia after antenatal corticosteroid administration: It's all about timing. Int J Gynaecol Obstet. 2021 Oct 8. [QxMD MEDLINE Link].

8. Dude AM, Yee LM, Henricks A, Eucalitto P, Badreldin N. Neonatal hypoglycemia after antenatal late preterm steroids in individuals with diabetes. J Perinatol. 2021 Nov 13. [QxMD MEDLINE Link].

9. Yamamoto JM, Kallas-Koeman MM, Butalia S, Lodha AK, Donovan LE. Large-for-Gestational-Age Neonate Predicts a 2.5-Fold Increased Odds of Neonatal Hypoglycemia in Women with Type 1 Diabetes. Diabetes Metab Res Rev. 2016 May 17. [QxMD MEDLINE Link]. [Full Text].

10. DePuy AM, Coassolo KM, Som DA, Smulian JC. Neonatal hypoglycemia in term, nondiabetic pregnancies. Am J Obstet Gynecol. 2009 May. 200(5):e45-51. [QxMD MEDLINE Link].

11. Tita AT, Landon MB, Spong CY, et al. Timing of elective repeat cesarean delivery at term and neonatal outcomes. N Engl J Med. 2009 Jan 8. 360(2):111-20. [QxMD MEDLINE Link]. [Full Text].

12. Daly LP, Osterhoudt KC, Weinzimer SA. Presenting features of idiopathic ketotic hypoglycemia. J Emerg Med. 2003 Jul. 25(1):39-43. [QxMD MEDLINE Link].

13. Birkebaek NH, Drivvoll AK, Aakeson K, et al. Incidence of severe hypoglycemia in children with type 1 diabetes in the Nordic countries in the period 2008-2012: association with hemoglobin A _1c and treatment modality. BMJ Open Diabetes Res Care. 2017. 5 (1):e000377. [QxMD MEDLINE Link]. [Full Text].

14. Pacaud D, Hermann JM, Karges B, et al. Risk of recurrent severe hypoglycemia remains associated with a past history of severe hypoglycemia up to 4 years: results from a large prospective contemporary pediatric cohort of the DPV initiative. Pediatr Diabetes. 2017 Dec 8. [QxMD MEDLINE Link].

15. Mahajan G, Mukhopadhyay K, Attri S, Kumar P. Neurodevelopmental Outcome of Asymptomatic Hypoglycemia Compared With Symptomatic Hypoglycemia and Euglycemia in High-Risk Neonates. Pediatr Neurol. 2017 Sep. 74:74-9. [QxMD MEDLINE Link].

16. Goode RH, Rettiganti M, Li J, et al. Developmental Outcomes of Preterm Infants With Neonatal Hypoglycemia. Pediatrics. 2016 Dec. 138 (6):[QxMD MEDLINE Link].

17. [Guideline] Wight N, Marinelli KA. ABM clinical protocol #1: guidelines for glucose monitoring and treatment of hypoglycemia in breastfed neonates. Breastfeed Med. 2006 Autumn. 1(3):178-84. [QxMD MEDLINE Link].

18. Ly TT, Maahs DM, Rewers A, et al. Assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes. 2014 Sep. 15 Suppl 20:180-92. [QxMD MEDLINE Link].

19. LeBlanc S, Haushalter J, Seashore C, Wood KS, Steiner MJ, Sutton AG. A Quality-Improvement Initiative to Reduce NICU Transfers for Neonates at Risk for Hypoglycemia. Pediatrics. 2018 Feb 8. [QxMD MEDLINE Link].

20. [Guideline] Yorifuji T, Horikawa R, Hasegawa T, et al. Clinical practice guidelines for congenital hyperinsulinism. Clin Pediatr Endocrinol. 2017. 26 (3):127-52. [QxMD MEDLINE Link]. [Full Text].

21. [Guideline] Thornton PS, Stanley CA, De Leon DD, et al. Recommendations from the Pediatric Endocrine Society for Evaluation and Management of Persistent Hypoglycemia in Neonates, Infants, and Children. J Pediatr. 2015 Aug. 167 (2):238-45. [QxMD MEDLINE Link]. [Full Text].

Robert P Hoffman, MD Professor and Program Director, Department of Pediatrics, Ohio State University College of Medicine; Pediatric Endocrinologist, Division of Pediatric, Endocrinology, Diabetes, and Metabolism, Nationwide Children's Hospital

Robert P Hoffman, MD is a member of the following medical societies: American College of Pediatricians, American Diabetes Association, American Pediatric Society, Christian Medical and Dental Associations, Endocrine Society, Midwest Society for Pediatric Research, Pediatric Endocrine Society, Society for Pediatric Research

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London) Professor and Chair, First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children's Hospital, Greece; UNESCO Chair on Adolescent Health Care, University of Athens, Greece

George P Chrousos, MD, FAAP, MACP, MACE, FRCP(London) is a member of the following medical societies: American Academy of Pediatrics, American College of Physicians, American Pediatric Society, American Society for Clinical Investigation, Association of American Physicians, Endocrine Society, Pediatric Endocrine Society, Society for Pediatric Research, American College of Endocrinology

Disclosure: Nothing to disclose.

Sasigarn A Bowden, MD, FAAP Professor of Pediatrics, Section of Pediatric Endocrinology, Metabolism and Diabetes, Department of Pediatrics, Ohio State University College of Medicine; Pediatric Endocrinologist, Division of Endocrinology, Nationwide Children’s Hospital; Affiliate Faculty/Principal Investigator, Center for Clinical Translational Research, Research Institute at Nationwide Children’s Hospital

Sasigarn A Bowden, MD, FAAP is a member of the following medical societies: American Society for Bone and Mineral Research, Central Ohio Pediatric Society, Endocrine Society, International Society for Pediatric and Adolescent Diabetes, Pediatric Endocrine Society, Society for Pediatric Research

Disclosure: Nothing to disclose.

Karl S Roth, MD Retired Professor and Chair, Department of Pediatrics, Creighton University School of Medicine

Karl S Roth, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Pediatrics, American College of Nutrition, American Pediatric Society, American Society for Nutrition, American Society of Nephrology, Association of American Medical Colleges, Medical Society of Virginia, New York Academy of Sciences, Sigma Xi, The Scientific Research Honor Society, Society for Pediatric Research, Southern Society for Pediatric Research

Disclosure: Nothing to disclose.

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