Hyposomatotropism (Growth Hormone Deficiency) Questions & Answers

Updated: Jan 24, 2019
  • Author: Sunil Kumar Sinha, MD; Chief Editor: Robert P Hoffman, MD  more...
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Questions & Answers

Overview

What is hyposomatotropism (growth hormone deficiency [GHD])?

What are the indications for recombinant human growth hormone (rhGH) therapy in children?

What are the indications for recombinant human growth hormone (rhGH) therapy in adults?

How is hyposomatotropism (growth hormone deficiency [GHD]) diagnosed?

What is the role of human pituitary-derived growth hormone (pit-hGH) in the treatment of hyposomatotropism (growth hormone deficiency [GHD])?

What are the limitations of human pituitary-derived growth hormone (pit-hGH) for the treatment of hyposomatotropism (growth hormone deficiency [GHD])?

Why is human pituitary-derived growth hormone (pit-hGH) no longer used in the treatment of hyposomatotropism (growth hormone deficiency [GHD])?

What is the anatomy of the pituitary gland relevant to hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of growth hormone (GH) in the pathophysiology of hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of insulinlike growth factors (IGFs) in the pathophysiology of hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of insulinlike growth factor binding proteins (IGFBPs) in the pathophysiology of hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of sex steroids in the pathophysiology of hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of thyroid hormone in the pathophysiology of hyposomatotropism (growth hormone deficiency [GHD])?

What causes isolated hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of genetics in the etiology of hyposomatotropism (growth hormone deficiency [GHD])?

Which developmental malformations are associated with hyposomatotropism (growth hormone deficiency [GHD])?

Which labor and delivery complications are associated with hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of malignancies in the etiology of hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of radiation in the etiology of hyposomatotropism (growth hormone deficiency [GHD])?

Which developmental abnormalities of the pituitary are associated with hyposomatotropism (growth hormone deficiency [GHD])?

What is the prevalence of hyposomatotropism (growth hormone deficiency [GHD])?

What is the prognosis of hyposomatotropism (growth hormone deficiency [GHD])?

What is the mortality risk associated with hyposomatotropism (growth hormone deficiency [GHD])?

What is included in the patient education about hyposomatotropism (growth hormone deficiency [GHD])?

Presentation

Which clinical history findings are characteristic of congenital hyposomatotropism (growth hormone deficiency [GHD])?

Which clinical history findings are characteristic of acquired hyposomatotropism (growth hormone deficiency [GHD])?

Which physical findings are characteristic of congenital hyposomatotropism (growth hormone deficiency [GHD])?

Which physical findings are characteristic of acquired hyposomatotropism (growth hormone deficiency [GHD])?

DDX

Which conditions should be included in the differential diagnoses of primary growth disorders in hyposomatotropism (growth hormone deficiency [GHD])?

Which conditions should be included in the differential diagnoses of secondary growth disorders in hyposomatotropism (growth hormone deficiency [GHD])?

What are the differential diagnoses for Hyposomatotropism (Growth Hormone Deficiency)?

Workup

What is included in the workup of hyposomatotropism (growth hormone deficiency [GHD])?

What are the diagnostic criteria for hyposomatotropism (growth hormone deficiency [GHD])?

What are the possible limitations of serum GH concentration measurements to diagnose hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of GH RIAs in the workup of hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of IGF RIAs in the workup of hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of IGFBPs RIAs in the workup of hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of radiography in the workup of hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of MRI in the workup of hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of provocative testing in the workup of hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of an insulin tolerance test in the workup of hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of a clonidine stimulation test in the workup of hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of a levodopa-propranolol HCI test in the workup of hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of an arginine HCI test in the workup of hyposomatotropism (growth hormone deficiency [GHD])?

What is the role of a glucagon test in the workup of hyposomatotropism (growth hormone deficiency [GHD])?

Treatment

Which factors affect height outcome from the treatment of hyposomatotropism (growth hormone deficiency [GHD])?

What is the effective replacement dosage rhGH in the treatment of hyposomatotropism (growth hormone deficiency [GHD])?

What are the patterns of growth during childhood for patients receiving hyposomatotropism (growth hormone deficiency [GHD]) treatment?

How is hyposomatotropism (growth hormone deficiency [GHD]) treated?

Which specialist consultations are beneficial to patients with hyposomatotropism (growth hormone deficiency [GHD])?

What are the possible complications of hyposomatotropism (growth hormone deficiency [GHD]) treatment?

What are the indications for discontinuation of rhGH therapy for hyposomatotropism (growth hormone deficiency [GHD])?

How does rhGH therapy for hyposomatotropism (growth hormone deficiency [GHD]) affect the risk for cancer?

Guidelines

What are the PES guidelines on the treatment of hyposomatotropism (growth hormone deficiency [GHD])?

What are the Endocrine Society guidelines on the evaluation and treatment of hyposomatotropism (growth hormone deficiency [GHD])?

Medications

What is the role of medications in the treatment of hyposomatotropism (growth hormone deficiency [GHD])?

Which novel treatments of hyposomatotropism (growth hormone deficiency [GHD]) have been proposed?

What is the role of gonadotropin-releasing hormone (GnRH) agonists in the treatment of hyposomatotropism (growth hormone deficiency [GHD])?

Which medications in the drug class IGFs are used in the treatment of Hyposomatotropism (Growth Hormone Deficiency)?

Which medications in the drug class rhGHs are used in the treatment of Hyposomatotropism (Growth Hormone Deficiency)?