Congenital Hyperinsulinism Differential Diagnoses

Updated: Dec 16, 2015
  • Author: Robert S Gillespie, MD, MPH; Chief Editor: Stephen Kemp, MD, PhD  more...
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Diagnostic Considerations

Misdiagnosis of hypoglycemic seizure as epileptic seizure will result in inappropriate treatment with anticonvulsants and failure to treat with glucose. Consider associated endocrine abnormalities, such as multiple endocrine neoplasia type I.

In addition to these and the conditions listed in the differential diagnosis, other problems to be considered include the following:

  • Transient hypoglycemia of the newborn

  • Erythroblastosis fetalis

  • Drug effect (eg, tocolytics, quinine)

  • Withdrawal of parenteral nutrition or dextrose-containing intravenous (IV) fluid

  • Exogenous insulin administration (eg, Munchausen syndrome, Munchausen syndrome by proxy)

  • Ingestion of oral hypoglycemic agents

  • Hyperinsulinism with hyperammonemia

  • Hyperinsulinism-hyperammonemic syndrome

  • Insulin-secreting adenoma

  • Ketotic hypoglycemia

Differential Diagnoses