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Media Gallery

Colonoscopic image of large ulcer and inflammation of descending colon in 12-year-old boy with Crohn disease.
Histologic features of chronic colitis with crypt atrophy and branching and lymphocytic infiltrate. Hematoxylin-eosin staining. Image courtesy of Dr E Ruchelli.
Colonic granuloma in patient with Crohn disease. Hematoxylin-eosin staining. Image courtesy of Dr E Ruchelli.
Image obtained during upper gastrointestinal series with small-bowel follow-through shows narrowing and irregularity in distal ileum in 16-year-old male adolescent with Crohn disease.
Inflamed terminal ileum in 10-year-old girl with Crohn disease.
Small abscess on right side of anal sphincter in 9-year-old boy with Crohn disease.

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Author

Andrew B Grossman, MD Associate Professor of Clinical Pediatrics, Co-Director, Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania

Andrew B Grossman, MD is a member of the following medical societies: American Gastroenterological Association, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Crohn's and Colitis Foundation of America

Disclosure: Nothing to disclose.

Coauthor(s)

Petar Mamula, MD Professor, Department of Pediatrics, Division of Gastroenterology and Nutrition, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine

Petar Mamula, MD is a member of the following medical societies: American Academy of Pediatrics, American Gastroenterological Association, American Society for Gastrointestinal Endoscopy, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

Disclosure: Nothing to disclose.

Chief Editor

Carmen Cuffari, MD Associate Professor, Department of Pediatrics, Division of Gastroenterology/Nutrition, Johns Hopkins University School of Medicine

Carmen Cuffari, MD is a member of the following medical societies: American College of Gastroenterology, American Gastroenterological Association, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Royal College of Physicians and Surgeons of Canada

Disclosure: Received honoraria from Prometheus Laboratories for speaking and teaching; Received honoraria from Abbott Nutritionals for speaking and teaching. for: Abbott Nutritional, Abbvie, speakers' bureau.

Acknowledgements

Robert Baldassano, MD Director, Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology and Nutrition, Associate Professor, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania

Robert Baldassano, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Pediatrics, American Gastroenterological Association, and North American Society for Pediatric Gastroenterology and Nutrition

Disclosure: Nothing to disclose.

Stefano Guandalini, MD Director, University of Chicago Celiac Disease Program, Section Chief of Gastroenterology, Hepatology and Nutrition; Professor, Department of Pediatrics, University of Chicago Comer Children's Hospital

Stefano Guandalini, MD is a member of the following medical societies: American Gastroenterological Association, European Society for Paediatric Gastroenterology, Hepatology & Nutrition, and North American Society for Pediatric Gastroenterology and Nutrition

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

	Crohn Disease	Ulcerative Colitis
Characteristic
Distribution	Entire GI tract	Colon only, although gastritis recognized
Distribution	Skip lesions	Continuous involvement proximally from rectum
Pathology	Full thickness	Mucosa only
Pathology	Granulomas (30%)	No granulomas
Radiology	Entire GI tract	Colon only
	Skip lesions	Continuous involvement proximally from rectum
	Fistulas, abscesses, fibrotic strictures	Mucosal disease only
Cancer risk	Increased	Estimated 1%/y, starting 10 y after diagnosis
Presentation
Bleeding	Common	Very common
Obstruction	Common	Uncommon
Fistula	Common	None
Weight loss	Common	Uncommon
Perianal disease	Common	Rare
GI = gastrointestinal.

Pediatric Crohn Disease Questions & Answers

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