Superior Mesenteric Artery (SMA) Syndrome Medication

Updated: Dec 31, 2018
  • Author: Frederick Merrill Karrer, MD, FACS; Chief Editor: Carmen Cuffari, MD  more...
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Medication Summary

Drug therapy currently is not a component of the standard of care for this syndrome. Metoclopramide may be used to provide a prokinetic effect. Caution should be taken if patient has signs of complete obstruction.


Prokinetic agents

Class Summary

These stimulate motility of the GI tract. GI smooth muscle is regulated by autonomic innervation, local reflexes, and hormones. Peristalsis is induced and causes the gut contents to move, encouraging digestion.

Metoclopramide (Reglan, Clopra)

Dopamine antagonist that stimulates acetylcholine release in the myenteric plexus. Acts centrally on chemoreceptor triggers in the floor of the fourth ventricle, causing important antiemetic activity.