Pediatric Zollinger-Ellison Syndrome Differential Diagnoses

Updated: Oct 06, 2017
  • Author: Tiffany J Patton, MD; Chief Editor: Carmen Cuffari, MD  more...
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Diagnostic Considerations

As noted earlier, owing to the generally nonspecific GI symptoms and signs of Zollinger-Ellison syndrome (ZES), particularly in children, the correct diagnosis may be delayed. When evaluating patients with suspected Zollinger-Ellison syndrome, also consider reflux disease, Barrett esophagitis, esophageal stenosis, and the following conditions:

  • Hypochlorhydria due to chronic atrophic gastritis

  • Prolonged proton pump inhibitor (PPI) use

  • GI bleeding

  • Gastric outlet obstruction

Differential Diagnoses