Anorectal Abscess in Children Medication

Updated: Dec 02, 2019
  • Author: Nelson G Rosen, MD, FACS, FAAP; Chief Editor: Robert K Minkes, MD, PhD  more...
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Medication Summary

The goals of pharmacotherapy are to reduce morbidity, prevent complications, and eradicate the infection. Anorectal abscesses often grow mixed florae and can be well covered by various antibiotic choices.



Class Summary

Antibacterial therapy must cover all likely pathogens in the context of the clinical setting.

Cephalexin (Keflex)

Cephalexin is a first-generation cephalosporin that arrests bacterial growth by inhibiting bacterial cell-wall synthesis. It has bactericidal activity against rapidly growing organisms. Its primary activity is against skin flora; it is used for skin infections or prophylaxis in minor procedures.

Trimethoprim/sulfamethoxazole (Bactrim, Bactrim DS, Septra DS)

Trimethoprim/sulfamethoxazole (TMP-SMZ) discourages bacterial growth by inhibiting the synthesis of dihydrofolic acid.

Amoxicillin and clavulanic acid (Augmentin)

This drug combination treats bacteria resistant to beta-lactam antibiotics. For children older than 3 months, base the dosing protocol on amoxicillin content. Because of different amoxicillin/clavulanic acid ratios in the 250-mg tablet (250/125) versus the 250-mg chewable tablet (250/62.5), do not use the 250-mg tablet until the child weighs more than 40 kg.