Genetics of Hyperammonemia Follow-up

Updated: Sep 20, 2018
  • Author: Karl S Roth, MD; Chief Editor: Maria Descartes, MD  more...
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Follow-up

Transfer

During initial stabilization of patients with hyperammonemia, transfer to an academic medical center for further investigation and long-term treatment is mandatory. Transfer is especially necessary for newborns, who may require highly specialized equipment and personnel for hemodialysis, for example.

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Complications

Hyperammonemia can cause irreversible neurotoxicity and cell death in the CNS.

Acutely, the effects can conspire to cause cerebral edema, increased intracranial pressure, and death.

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Prognosis

Regardless of the etiology, prognosis depends on both the severity and duration of the ammonia level elevation. The sites of damage are not predictable and require careful neurologic evaluation for documentation.

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