Silver-Russell Syndrome Questions & Answers

Updated: Feb 11, 2019
  • Author: Sunil Kumar Sinha, MD; Chief Editor: Luis O Rohena, MD, MS, FAAP, FACMG  more...
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Questions & Answers

Overview

What is Silver-Russell syndrome (SRS)?

What is the pathophysiology of Silver-Russell syndrome (SRS)?

What is the prevalence of Silver-Russell syndrome (SRS)?

What is the mortality and morbidity associated with Silver-Russell syndrome (SRS)?

What are the sexual predilections of Silver-Russell syndrome (SRS)?

At what age are the clinical features of Silver-Russell syndrome (SRS) most evident?

Presentation

What are the diagnostic criteria for Silver-Russell syndrome (SRS)?

Which dysmorphic findings are characteristic of Silver-Russell syndrome (SRS)?

Which growth and skeletal findings are characteristic of Silver-Russell syndrome (SRS)?

Which genital anomalies are characteristic of Silver-Russell syndrome (SRS)?

Which radiographic findings are characteristic of Silver-Russell syndrome (SRS)?

How frequently are cardiac defects or malignancies associated with Silver-Russell syndrome (SRS)?

What causes Silver-Russell syndrome (SRS)?

DDX

Which conditions are included in the differential diagnoses of Silver-Russell syndrome (SRS)?

What are the differential diagnoses for Silver-Russell Syndrome?

Workup

How is Silver-Russell syndrome (SRS) diagnosed?

What is the role of lab studies in the workup of Silver-Russell syndrome (SRS)?

What is the role of imaging studies in the workup of Silver-Russell syndrome (SRS)?

Treatment

Which specialists make up the multidisciplinary care team needed to treat Silver-Russell syndrome (SRS)?

How is Silver-Russell syndrome (SRS) treated?

What is the role of surgery in the treatment of Silver-Russell syndrome (SRS)?

Which specialist consultations are beneficial to patients with Silver-Russell syndrome (SRS)?

Which dietary modifications are used in the treatment of Silver-Russell syndrome (SRS)?

Guidelines

What are the guidelines for the diagnosis and treatment of Silver-Russell syndrome (SRS)?

Medications

Which medications are used in the treatment of Silver-Russell syndrome (SRS) treatment?

Follow-up

What is included in the monitoring and long-term care of patients with Silver-Russell syndrome (SRS)?

When is inpatient care indicated for the treatment of Silver-Russell syndrome (SRS)?

What is the prognosis of Silver-Russell syndrome (SRS)?

What is included in patient education about Silver-Russell syndrome (SRS)?