Labial Adhesions Medication

Updated: May 20, 2022
  • Author: Kenneth G Nepple, MD; Chief Editor: Andrea L Zuckerman, MD  more...
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Medication Summary

The primary treatment of labial adhesions is direct application of topical estrogen cream to the labia minora. Adverse systemic effects from estrogen application are rare and include local irritations, vulvar pigmentation, and breast enlargement; these effects are reversible once treatment is stopped.


Estrogen Derivatives

Class Summary

Topical estrogens are indicated for the treatment of atrophic urogenital changes (eg, atrophic vaginitis, kraurosis vulvae, and labial adhesions).

Estradiol, topical (Estrace)

Topical estrogens may reduce pH levels and mature the vaginal and urethral mucosa after 12 weeks of therapy, thereby improving mucosal atrophy. The cream can be applied to the adhesions 2-3 times daily for several weeks. Once the adhesions start to separate, the application frequency can be decreased.

Conjugated estrogens, vaginal (Premarin Vaginal Cream)