Overview
What is antithrombin III (ATIII) deficiency?
Which lab tests are performed in the workup of antithrombin III (ATIII) deficiency?
What is the role of imaging studies in the evaluation of antithrombin III (ATIII) deficiency?
How is antithrombin III (ATIII) deficiency treated?
What is the pathophysiology of antithrombin III (ATIII) deficiency?
What is the role of genetics in the pathophysiology of antithrombin III (ATIII) deficiency?
What is pathophysiology of acquired antithrombin III (ATIII) deficiency?
What is the prevalence of antithrombin III (ATIII) deficiency in the US?
What is the global prevalence of antithrombin III (ATIII) deficiency?
What is the morbidity associated with antithrombin III (ATIII) deficiency?
What are the racial predilections of antithrombin III (ATIII) deficiency?
What are the sexual predilections of antithrombin III (ATIII) deficiency?
Which age groups have highest prevalence of antithrombin III (ATIII) deficiency?
Presentation
What is the focus of clinical history for the diagnosis of antithrombin III (ATIII) deficiency?
What the risk factors for antithrombin III (ATIII) deficiency?
Which clinical history findings are characteristic of antithrombin III (ATIII) deficiency?
Which physical findings are characteristic of antithrombin III (ATIII) deficiency?
What causes antithrombin III (ATIII) deficiency?
DDX
What are the differential diagnoses for Antithrombin III Deficiency?
Workup
Which lab studies are performed in the workup of antithrombin III (ATIII) deficiency?
What is the role of antithrombin assays in the workup of antithrombin III (ATIII) deficiency?
What is the role of factor V Leiden testing in the workup of antithrombin III (ATIII) deficiency?
What is the role of homocysteine measurement in the workup of antithrombin III (ATIII) deficiency?
What is the role of echocardiography in the workup of antithrombin III (ATIII) deficiency?
What is the role of Doppler ultrasonography in the workup of antithrombin III (ATIII) deficiency?
What is the role of CT scanning and MRA in the workup of antithrombin III (ATIII) deficiency?
When is a central venous line indicated in children with antithrombin III (ATIII) deficiency?
Treatment
How is antithrombin III (ATIII) deficiency treated?
What is the role of enoxaparin (Lovenox) in the treatment of antithrombin III (ATIII) deficiency?
What is the role of warfarin (Coumadin) in the treatment of antithrombin III (ATIII) deficiency?
How is acquired antithrombin III (ATIII) deficiency treated?
What is the role of LMWH in the treatment of antithrombin III (ATIII) deficiency?
How is asymptomatic antithrombin III (ATIII) deficiency treated?
What surgical prophylaxis is required for patients with antithrombin III (ATIII) deficiency?
Which specialists should be consulted in the treatment of antithrombin III (ATIII) deficiency?
Which dietary modifications are used in the treatment of antithrombin III (ATIII) deficiency?
Which activity modifications are used in the treatment of antithrombin III (ATIII) deficiency?
Medications
What is the role of medications in the treatment of antithrombin III (ATIII) deficiency?
Follow-up
Which specialist consultations are beneficial to patients with antithrombin III (ATIII) deficiency?
What are the possible complications of antithrombin III (ATIII) deficiency?
What is the prognosis of antithrombin III (ATIII) deficiency?
What should be included in patient education about antithrombin III (ATIII) deficiency?
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Antithrombin (AT) sites of action.