Antithrombin III Deficiency Questions & Answers

1. Gaman AM, Gaman GD. Deficiency Of Antithrombin III (AT III) - Case Report and Review of the Literature. Curr Health Sci J. 2014 Apr-Jun. 40 (2):141-3. [QxMD MEDLINE Link]. [Full Text].

2. Hsu E, Moosavi L. Biochemistry, Antithrombin III. StatPearls. 2021 Jan. [QxMD MEDLINE Link]. [Full Text].

3. Senst B, Tadi P, Goyal A, Jan A. Hypercoagulability. StatPearls. 2021 Jan. [QxMD MEDLINE Link]. [Full Text].

4. Yilmaz S, Gunaydin S. Inherited risk factors in low-risk venous thromboembolism in patients under 45 years. Interact Cardiovasc Thorac Surg. 2015 Jan. 20 (1):21-3. [QxMD MEDLINE Link].

5. Beauchamp NJ, Pike RN, Daly M, et al. Antithrombins Wibble and Wobble (T85M/K): archetypal conformational diseases with in vivo latent-transition, thrombosis, and heparin activation. Blood. 1998 Oct 15. 92(8):2696-706. [QxMD MEDLINE Link].

6. Kuhle S, Lane DA, Jochmanns K, et al. Homozygous antithrombin deficiency type II (99 Leu to Phe mutation) and childhood thromboembolism. Thromb Haemost. 2001 Oct. 86(4):1007-11. [QxMD MEDLINE Link].

7. Di Minno MN, Dentali F, Lupoli R, Ageno W. Mild antithrombin deficiency and risk of recurrent venous thromboembolism: a prospective cohort study. Circulation. 2014 Jan 28. 129 (4):497-503. [QxMD MEDLINE Link].

8. Sokol J, Timp JF, le Cessie S, et al. Mild Antithrombin Deficiency and Risk of Recurrent Venous Thromboembolism: Results from the MEGA follow-up Study. J Thromb Haemost. 2018 Jan 28. [QxMD MEDLINE Link].

9. Rosenberg RD. Actions and interactions of antithrombin and heparin. N Engl J Med. 1975 Jan 16. 292(3):146-51. [QxMD MEDLINE Link].

10. Undas A, Brummel K, Musial J, Mann KG, Szczeklik A. Blood coagulation at the site of microvascular injury: effects of low-dose aspirin. Blood. 2001 Oct 15. 98(8):2423-31. [QxMD MEDLINE Link].

11. Rodgers GM. Role of antithrombin concentrate in treatment of hereditary antithrombin deficiency. An update. Thromb Haemost. 2009 May. 101(5):806-12. [QxMD MEDLINE Link].

12. Maclean PS, Tait RC. Hereditary and acquired antithrombin deficiency: epidemiology, pathogenesis and treatment options. Drugs. 2007. 67(10):1429-40. [QxMD MEDLINE Link].

13. Lenz B, Samardzija M, Drenjancevic D, Zibar D, Samardzija M, Milostic-Srb A. The investigation of hereditary and acquired thrombophilia risk factors in the development of complications in pregnancy in Croatian women. J Matern Fetal Neonatal Med. 2016. 29 (2):264-9. [QxMD MEDLINE Link].

14. Rheaume M, Weber F, Durand M, Mahone M. Pregnancy-Related Venous Thromboembolism Risk in Asymptomatic Women With Antithrombin Deficiency: A Systematic Review. Obstet Gynecol. 2016 Apr. 127 (4):649-56. [QxMD MEDLINE Link].

15. [Guideline] Institute for Clinical Systems Improvement (ICSI). Venous thromboembolism. ICSI. 2007 Jun. [Full Text].

16. Mitchell L, Andrew M, Hanna K, et al. Trend to efficacy and safety using antithrombin concentrate in prevention of thrombosis in children receiving l-asparaginase for acute lymphoblastic leukemia. Results of the PAARKA study. Thromb Haemost. 2003 Aug. 90(2):235-44. [QxMD MEDLINE Link].

17. Gardner AJ, Kirkin DJ, Rodriguez-Villar S, Leoz Abellanas G, Tee A, Valentin A. Antithrombin III deficiency-induced coagulopathy in the context of COVID-19: a case series. Br J Haematol. 2021 Sep. 194 (6):1007-9. [QxMD MEDLINE Link]. [Full Text].

18. Baiges A, de la Morena-Barrio ME, Turon F, et al. Congenital antithrombin deficiency in patients with splanchnic vein thrombosis. Liver Int. 2019 Dec 29. [QxMD MEDLINE Link].

19. Vossen CY, Conard J, Fontcuberta J, et al. Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT). J Thromb Haemost. 2005 Mar. 3(3):459-64. [QxMD MEDLINE Link].

20. Young G, Albisetti M, Bonduel M, et al. Impact of inherited thrombophilia on venous thromboembolism in children: a systematic review and meta-analysis of observational studies. Circulation. 2008 Sep 23. 118(13):1373-82. [QxMD MEDLINE Link].

James L Harper, MD Associate Professor, Department of Pediatrics, Division of Hematology/Oncology and Bone Marrow Transplantation, Associate Chairman for Education, Department of Pediatrics, University of Nebraska Medical Center; Associate Clinical Professor, Department of Pediatrics, Creighton University School of Medicine; Director, Continuing Medical Education, Children's Memorial Hospital; Pediatric Director, Nebraska Regional Hemophilia Treatment Center

James L Harper, MD is a member of the following medical societies: American Society of Pediatric Hematology/Oncology, American Federation for Clinical Research, Council on Medical Student Education in Pediatrics, Hemophilia and Thrombosis Research Society, American Academy of Pediatrics, American Association for Cancer Research, American Society of Hematology

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Gary D Crouch, MD Associate Professor, Program Director of Pediatric Hematology-Oncology Fellowship, Department of Pediatrics, Uniformed Services University of the Health Sciences

Gary D Crouch, MD is a member of the following medical societies: American Academy of Pediatrics, American Society of Hematology

Disclosure: Nothing to disclose.

Hassan M Yaish, MD Medical Director, Intermountain Hemophilia and Thrombophilia Treatment Center; Professor of Pediatrics, University of Utah School of Medicine; Director of Hematology, Pediatric Hematologist/Oncologist, Department of Pediatrics, Primary Children's Medical Center

Hassan M Yaish, MD is a member of the following medical societies: American Academy of Pediatrics, American Medical Association, American Society of Hematology, American Society of Pediatric Hematology/Oncology, Michigan State Medical Society, New York Academy of Sciences

Disclosure: Nothing to disclose.

Gary R Jones, MD Associate Medical Director, Clinical Development, Berlex Laboratories

Gary R Jones, MD is a member of the following medical societies: American Academy of Pediatrics, American Society of Pediatric Hematology/Oncology, and Western Society for Pediatric Research

Disclosure: Nothing to disclose.

• Print this section
• Print the entire contents of
• Print the entire contents of article