Antithrombin III Deficiency Questions & Answers

Updated: Feb 10, 2018
  • Author: James L Harper, MD; Chief Editor: Hassan M Yaish, MD  more...
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Questions & Answers

Overview

What is antithrombin III (ATIII) deficiency?

Which lab tests are performed in the workup of antithrombin III (ATIII) deficiency?

What is the role of imaging studies in the evaluation of antithrombin III (ATIII) deficiency?

How is antithrombin III (ATIII) deficiency treated?

What is the pathophysiology of antithrombin III (ATIII) deficiency?

What is the role of genetics in the pathophysiology of antithrombin III (ATIII) deficiency?

What is pathophysiology of acquired antithrombin III (ATIII) deficiency?

What is the prevalence of antithrombin III (ATIII) deficiency in the US?

What is the global prevalence of antithrombin III (ATIII) deficiency?

What is the morbidity associated with antithrombin III (ATIII) deficiency?

What are the racial predilections of antithrombin III (ATIII) deficiency?

What are the sexual predilections of antithrombin III (ATIII) deficiency?

Which age groups have highest prevalence of antithrombin III (ATIII) deficiency?

Presentation

What is the focus of clinical history for the diagnosis of antithrombin III (ATIII) deficiency?

What the risk factors for antithrombin III (ATIII) deficiency?

Which clinical history findings are characteristic of antithrombin III (ATIII) deficiency?

Which physical findings are characteristic of antithrombin III (ATIII) deficiency?

What causes antithrombin III (ATIII) deficiency?

DDX

What are the differential diagnoses for Antithrombin III Deficiency?

Workup

Which lab studies are performed in the workup of antithrombin III (ATIII) deficiency?

What is the role of antithrombin assays in the workup of antithrombin III (ATIII) deficiency?

What is the role of prothrombin time (PT) and activated partial thromboplastin time (aPTT) testing in the workup of antithrombin III (ATIII) deficiency?

What is the role of protein C and protein S testing in the workup of antithrombin III (ATIII) deficiency?

What is the role of factor V Leiden testing in the workup of antithrombin III (ATIII) deficiency?

What is the role of homocysteine measurement in the workup of antithrombin III (ATIII) deficiency?

What is the role of enzyme-linked immunoabsorbent assay (ELISA) in the workup of antithrombin III (ATIII) deficiency?

What is the role of echocardiography in the workup of antithrombin III (ATIII) deficiency?

What is the role of Doppler ultrasonography in the workup of antithrombin III (ATIII) deficiency?

What is the role of CT scanning and MRA in the workup of antithrombin III (ATIII) deficiency?

When is a central venous line indicated in children with antithrombin III (ATIII) deficiency?

Treatment

When is indefinite warfarin therapy indicated in the treatment of antithrombin III (ATIII) deficiency?

How is antithrombin III (ATIII) deficiency treated?

What is the role of enoxaparin (Lovenox) in the treatment of antithrombin III (ATIII) deficiency?

What is the role of warfarin (Coumadin) in the treatment of antithrombin III (ATIII) deficiency?

How is acquired antithrombin III (ATIII) deficiency treated?

What is the role of LMWH in the treatment of antithrombin III (ATIII) deficiency?

How is asymptomatic antithrombin III (ATIII) deficiency treated?

What surgical prophylaxis is required for patients with antithrombin III (ATIII) deficiency?

What should be considered before central venous line placement in patients with antithrombin III (ATIII) deficiency?

Which specialists should be consulted in the treatment of antithrombin III (ATIII) deficiency?

Which dietary modifications are used in the treatment of antithrombin III (ATIII) deficiency?

Which activity modifications are used in the treatment of antithrombin III (ATIII) deficiency?

Medications

What is the role of medications in the treatment of antithrombin III (ATIII) deficiency?

Which medications in the drug class Anticoagulants are used in the treatment of Antithrombin III Deficiency?

Which medications in the drug class Antithrombin-III concentrates are used in the treatment of Antithrombin III Deficiency?

Follow-up

Which specialist consultations are beneficial to patients with antithrombin III (ATIII) deficiency?

What are the possible complications of antithrombin III (ATIII) deficiency?

What is the prognosis of antithrombin III (ATIII) deficiency?

What should be included in patient education about antithrombin III (ATIII) deficiency?