Thrombasthenia Follow-up

Updated: Oct 25, 2018
  • Author: Vivian Y Chang, MD, MS; Chief Editor: Robert J Arceci, MD, PhD  more...
  • Print
Follow-up

Further Inpatient Care

Patients with thrombasthenia who receive platelet transfusion warrant admission for close observation.

Patients with significant blood loss may require close observation in a critical care setting.

Human leukocyte antigen (HLA)-matched platelets should be requested on standby for rebleeding episodes.

Avoid administering medications that interfere with platelet function (nonsteroidal anti-inflammatory drugs [NSAIDs]).

Next:

Deterrence/Prevention

Actions taken to prevent minor trauma are strongly suggested.

Previous
Next:

Complications

Alloimmunization is a possible complication of treating patients without matched blood.

Some patients have developed antibodies to the glycoprotein (GP) IIb-IIIa receptor.

Transfusion of HLA-matched platelets may prevent formation of anti-platelet antibodies, although even GT patients who have never been transfused have spontaneously developed anti-platelet antibodies. [27]

Previous
Next:

Prognosis

If patients receive timely platelet transfusions, the prognosis is very good.

Individuals with thrombasthenia and GI bleeding have the worst prognosis (see Mortality/Morbidity).

Previous
Next:

Patient Education

Advise patients with thrombasthenia to avoid contact sports or activities that may result in even minor trauma.

Encourage avoiding causes of GI bleeding (ie, alcohol, NSAIDs).

Previous