Pediatric Hereditary Elliptocytosis and Related Disorders Differential Diagnoses

Updated: Jan 30, 2019
  • Author: Trisha Simone Natanya Tavares, MD; Chief Editor: Vikramjit S Kanwar, MBBS, MBA, MRCP(UK), FAAP  more...
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DDx

Diagnostic Considerations

Elliptocytes may be observed in the blood smear in a wide variety of disorders; it is particularly common in iron-deficiency anemia. However, the percentage of elliptocytes in these conditions is usually low compared with that in hereditary elliptocytosis and its variants.

Pseudoelliptocytosis can occur as an artifact of blood film preparation. Pseudoelliptocytes are seen primarily at the tapered edge of a blood smear. They are not uniformly distributed.

Patients with hereditary elliptocytosis have also been found to have concurrent second hemolytic conditions such as glucose-6-phosphatase deficiency. This results in an additive effect on clinical severity. [12]

Differential Diagnoses