Kasabach-Merritt Syndrome Differential Diagnoses

Updated: Sep 12, 2022
  • Author: Alexandra C Cheerva, MD, MS; Chief Editor: Hassan M Yaish, MD  more...
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Diagnostic Considerations

In addition to the conditions listed in the differential diagnosis, other problems to be considered include the following:

  • Classic capillary hemangioma of infancy (a common infantile vascular anomaly but not associated with Kasabach-Merritt syndrome [KMS]; it affects girls more than boys and usually regresses spontaneously with age)

  • Congenital hemangiopericytoma

  • Cystic teratoma

  • Diffuse neonatal hemangiomatosis (DNH)

  • Encephalocele

  • Epithelioid hemangioendothelioma

  • Hereditary hemorrhagic telangiectasia

  • Infantile fibrosarcoma

  • Infantile myofibromatosis

  • Kaposiform hemangioendothelioma of infancy and childhood

  • Lumbar lipomyelomeningocele

  • Lymphatic malformation

  • Port-wine stain

  • Tufted angioma or angioblastoma

  • Thrombocytopenia

  • Venous malformation

Once the diagnosis of KMS is confirmed, it is important to inform parents regarding the signs of congestive heart failure and thrombocytopenia in infants (eg, difficulty feeding, petechiae, bruising, hematuria, and bloody stools).



Arterial Vascular Malformations Including Hemangiomas and Lymphangiomas

Arteriovenous Malformations

Consumption Coagulopathy


Hepatic Hemangiomas

Immune Thrombocytopenic Purpura

Infantile Hemangioma

Klippel-Trenaunay-Weber Syndrome

Teratomas and Other Germ Cell Tumors


Subcutaneous Fat Necrosis of the Newborn