Pediatric Thrombocytosis Differential Diagnoses

Updated: Aug 17, 2020
  • Author: Susumu Inoue, MD; Chief Editor: Hassan M Yaish, MD  more...
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Diagnostic Considerations

In pediatric patients with suspected secondary thrombocytosis (eg, iron deficiency anemia), if the patient has a thrombotic episode, other etiologies for thrombosis need to be considered (eg, hereditary thrombophilic disorder, antiphospholipid syndrome, nephrotic syndrome) because thrombosis as a complication of reactive thrombocytosis is extremely rare in children.

Reactive thrombocytosis is always temporary. If thrombocytosis persists long after the primary cause subsides or if it persists longer than 3 months, consider primary thrombocytosis, such as myeloproliferative disorder, asymptomatic hyposplenia or asplenia, or TPO or MPL mutation or polymorphism.

Differential Diagnoses