Pediatric Factor XIII Deficiency Differential Diagnoses

Updated: Jun 28, 2021
  • Author: Helge Dirk Hartung, MD; Chief Editor: Cameron K Tebbi, MD  more...
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Diagnostic Considerations

Acquired factor XIII (FXIII) deficiency can be caused by liver disease, inflammatory bowel disease, and disseminated intravascular coagulation, although controversy surrounds whether the low plasma levels in these conditions actually contribute to clinical bleeding. The development of autoantibodies to factor XIII has been reported. Consider other congenital coagulation factor deficiencies, most notably afibrinogenemia.