Pediatric Factor XIII Deficiency Follow-up

Updated: Jun 28, 2021
  • Author: Helge Dirk Hartung, MD; Chief Editor: Cameron K Tebbi, MD  more...
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Further Outpatient Care

Ideally, a comprehensive hemophilia care team with experience in the diagnosis and management of inherited bleeding disorders should monitor individuals with severe factor XIII (FXIII) deficiency.



For patients with homozygous factor XIII deficiency, prophylaxis is the best approach. [14]

  • Individuals who require plasma-derived factor XIII concentrate should be immunized with hepatitis A and hepatitis B vaccines.

  • Aspirin and other drugs that impair platelet function should be avoided.

  • Women at risk for spontaneous abortion should be evaluated for the need of enhanced prophylaxis starting in early pregnancy.


Patient Education

Provide patients and families with individual instruction and educational materials so they can understand factor XIII deficiency, recognize the symptoms and signs of bleeding, and identify emergency situations.

  • Patients should know where to receive emergency care and how to contact their treatment center for immediate treatment.

  • Patients should wear a MedicAlert bracelet or carry other identification stating their bleeding disorder and recommended therapy.

For excellent patient education resources, visit eMedicineHealth's Oral Health Center. Also, see eMedicineHealth's patient education article Teething.