Inherited Abnormalities of Fibrinogen Differential Diagnoses

Updated: Apr 20, 2023
  • Author: Suchitra S Acharya, MD, MBBS; Chief Editor: Cameron K Tebbi, MD  more...
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Diagnostic Considerations

Congenital afibrinogenemia and dysfibrinogenemia with bleeding must be differentiated from other congenital clotting factor deficiencies. In addition, a variety of coagulation disorders and clinical conditions that result in acquired hypofibrinogenemia, such as consumptive coagulopathy, hepatic failure, and L-asparaginase, valproate therapy, or lead to acquired dysfibrinogenemia, such as liver disease and some neoplasms, should be excluded.

Dysfibrinogenemia with thrombosis must be differentiated from other causes of congenital or acquired thrombophilia.

Differential Diagnoses