Bacterial Tracheitis Medication

Updated: Nov 01, 2023
  • Author: Sujatha Rajan, MD; Chief Editor: Russell W Steele, MD  more...
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Antibiotic agents

Class Summary

Empiric antimicrobial therapy in bacterial tracheitis must be comprehensive and should cover all likely pathogens in the context of the clinical setting.

Oxacillin (Bactocill, Prostaphlin)

Provides empiric therapy against etiologic agents, specifically penicillinase-producing strains of Staphylococcus.

Cefotaxime (Claforan)

Provides empiric therapy, especially against H influenzae, and modest activity against anaerobes.

Vancomycin (Vancocin)

May be used in severe cases or in cases with a history of allergies instead of oxacillin for coverage of gram-positive organisms (eg, S aureus, S pyogenes).

Clindamycin (Cleocin)

Use in combination with chloramphenicol in patients who are allergic to penicillin. Clindamycin in combination with cefuroxime is an acceptable regimen for patients who are not allergic.