Pediatric Botulism Medication

1. Kerner CAJ. Das Fettgift oder die Fettsaure und ihre Wirkungen auf den thierischen Organismus, ein Beytrag zur Untersuchung des in verdorbenen Wursten giftig wirkenden Stoffes. 1822.

2. Kerner CAJ. Neue Beobachtung uber die in Wurttemberg so haufig vorfallenden Verigiftungen durch den Genuss geraucherter Wurste. 1820.

3. Barnes M, Britton PN, Singh-Grewal D. Of war and sausages: A case-directed review of infant botulism. J Paediatr Child Health. 2013 Mar. 49(3):E232-4. [QxMD MEDLINE Link].

4. van Ermengem E. Ueber einen neuen Bacillus und seine Beziehungen zum Botulismus. Z Hyg Infektionskr. 1897. 26:1-56.

5. Merson MH, Dowell VR Jr. Epidemiologic, clinical and laboratory aspects of wound botulism. N Engl J Med. 1973 Nov 8. 289(19):1105-10. [QxMD MEDLINE Link].

6. Midura TF, Arnon SS. Infant botulism. Identification of Clostridium botulinum and its toxins in faeces. Lancet. 1976 Oct 30. 2(7992):934-6. [QxMD MEDLINE Link].

7. Pickett J, Berg B, Chaplin E, et al. Syndrome of botulism in infancy: clinical and electrophysiologic study. N Engl J Med. 1976 Sep 30. 295(14):770-2. [QxMD MEDLINE Link].

8. Schwartz KL, Austin JW, Science M. Constipation and poor feeding in an infant with botulism. CMAJ. 2012 Nov 20. 184(17):1919-22. [QxMD MEDLINE Link]. [Full Text].

9. Abdulla CO, Ayubi A, Zulfiquer F, Santhanam G, Ahmed MA, Deeb J. Infant botulism following honey ingestion. BMJ Case Rep. 2012 Sep 7. 2012:[QxMD MEDLINE Link]. [Full Text].

10. Kobayashi T, Haginoya K, Morimoto T, Hatakeyama T, Tsuchiya S. A case of infant botulism infection due to consumption of untreated well-water. J Pediatr. 2014 Apr. 164(4):931-3. [QxMD MEDLINE Link].

11. Benjamins LJ, Gourishankar A, Yataco-Marquez V, Cardona EH, de Ybarrondo L. Honey pacifier use among an indigent pediatric population. Pediatrics. 2013 Jun. 131(6):e1838-41. [QxMD MEDLINE Link].

12. Pifko E, Price A, Sterner S. Infant botulism and indications for administration of botulism immune globulin. Pediatr Emerg Care. 2014 Feb. 30(2):120-4; quiz 125-7. [QxMD MEDLINE Link].

13. DiPrisco BE, Chhabria S, Forem SL, Rosenberg RE. Ten-week-old girl with lethargy, weakness, and poor feeding. Clin Pediatr (Phila). 2013 Feb. 52(2):190-3. [QxMD MEDLINE Link].

14. Joseph CJ, Khoo TB, Lee KY. Flaccid paralysis in an infant associated with a dirty wound and application of honey. BMJ Case Rep. 2017 Jan 6. 2017:[QxMD MEDLINE Link].

15. Olson SC, Bergen CM, Andre-von Arnim AS, D'Angeli MA, Goldoft MJ, Russell D, et al. Acute neuromuscular weakness in a boy with a facial abscess contaminated with Clostridium botulinum. Pediatr Infect Dis J. 2012 Dec. 31(12):1307-9. [QxMD MEDLINE Link].

16. Ramroop S, Williams B, Vora S, Moshal K. Infant botulism and botulism immune globulin in the UK: a case series of four infants. Arch Dis Child. 2012 May. 97(5):459-60. [QxMD MEDLINE Link].

17. Shapiro RL, Hatheway C, Swerdlow DL. Botulism in the United States: a clinical and epidemiologic review. Ann Intern Med. 1998 Aug 1. 129(3):221-8. [QxMD MEDLINE Link]. [Full Text].

18. Horwitz MA, Hughes JM, Merson MH, Gangarosa EJ. Food-borne botulism in the United States, 1970-1975. J Infect Dis. 1977 Jul. 136(1):153-9. [QxMD MEDLINE Link].

19. Luquez C, Dykes JK, Yu PA, Raphael BH, Maslanka SE. First report worldwide of an infant botulism case due to Clostridium botulinum type E. J Clin Microbiol. 2010 Jan. 48(1):326-8. [QxMD MEDLINE Link]. [Full Text].

20. Zhang S, Wang Y, Qiu S, Dong Y, Xu Y, Jiang D. Multilocus outbreak of foodborne botulism linked to contaminated sausage in Hebei Province, China. Clin Infect Dis. 2010 Aug 1. 51(3):322-5. [QxMD MEDLINE Link].

21. May ML, Corkeron MA, Stretton M. Infant botulism in Australia: availability of human botulinum antitoxin for treatment. Med J Aust. 2010 Nov 15. 193(10):614-5. [QxMD MEDLINE Link].

22. Sheppard YD, Middleton D, Whitfield Y, Tyndel F, Haider S, Spiegelman J. Intestinal toxemia botulism in 3 adults, Ontario, Canada, 2006-2008. Emerg Infect Dis. 2012 Jan. 18(1):1-6. [QxMD MEDLINE Link].

23. Leclair D, Fung J, Isaac-Renton JL, et al. Foodborne botulism in Canada, 1985-2005. Emerg Infect Dis. 2013 Jun. 19(6):961-8. [QxMD MEDLINE Link]. [Full Text].

24. Fagan RP, McLaughlin JB, Castrodale LJ, Gessner BD, Jenkerson SA, Funk EA, et al. Endemic foodborne botulism among Alaska Native persons--Alaska, 1947-2007. Clin Infect Dis. 2011 Mar. 52(5):585-92. [QxMD MEDLINE Link].

25. Fagan RP, McLaughlin JB, Middaugh JP. Persistence of botulinum toxin in patients' serum: Alaska, 1959-2007. J Infect Dis. 2009 Apr 1. 199(7):1029-31. [QxMD MEDLINE Link].

26. Brown N, Desai S. Infantile botulism: a case report and review. J Emerg Med. 2013 Dec. 45(6):842-5. [QxMD MEDLINE Link].

27. Yuan J, Inami G, Mohle-Boetani J, Vugia DJ. Recurrent wound botulism among injection drug users in California. Clin Infect Dis. 2011 Apr 1. 52(7):862-6. [QxMD MEDLINE Link].

28. Quinn KK, Cherry JD, Shah NR, Christie LJ. A 3-month-old boy with concomitant respiratory syncytial virus bronchiolitis and infant botulism. Pediatr Infect Dis J. 2013 Feb. 32(2):195. [QxMD MEDLINE Link].

29. Filozov A, Kattan JA, Jitendranath L, Smith CG, Lúquez C, Phan QN. Asymmetric type F botulism with cranial nerve demyelination. Emerg Infect Dis. 2012 Jan. 18(1):102-4. [QxMD MEDLINE Link].

30. Hebert K, Haritos D, Kannikeswaran N. A floppy baby. Pediatr Emerg Care. 2015 Jun. 31 (6):419-21. [QxMD MEDLINE Link].

31. Wheeler C, Inami G, Mohle-Boetani J, Vugia D. Sensitivity of mouse bioassay in clinical wound botulism. Clin Infect Dis. 2009 Jun 15. 48(12):1669-73. [QxMD MEDLINE Link].

32. Sobel J. Diagnosis and treatment of botulism: a century later, clinical suspicion remains the cornerstone. Clin Infect Dis. 2009 Jun 15. 48(12):1674-5. [QxMD MEDLINE Link].

33. Umeda K, Seto Y, Kohda T, Mukamoto M, Kozaki S. A novel multiplex PCR method for Clostridium botulinum neurotoxin type A gene cluster typing. Microbiol Immunol. 2010 May. 54(5):308-12. [QxMD MEDLINE Link].

34. Kirchner S, Kramer KM, Schulze M, et al. Pentaplexed quantitative real-time PCR assay for the simultaneous detection and quantification of botulinum neurotoxin-producing clostridia in food and clinical samples. Appl Environ Microbiol. 2010 Jul. 76(13):4387-95. [QxMD MEDLINE Link]. [Full Text].

35. Chalk C, Benstead TJ, Keezer M. Medical treatment for botulism. Cochrane Database Syst Rev. 2011 Mar 16. CD008123. [QxMD MEDLINE Link].

36. Schussler E, Sobel J, Hsu J, Yu P, Meaney-Delman D, Grammer LC 3rd, et al. Workgroup Report by the Joint Task Force Involving American Academy of Allergy, Asthma & Immunology (AAAAI); Food Allergy, Anaphylaxis, Dermatology and Drug Allergy (FADDA) (Adverse Reactions to Foods Committee and Adverse Reactions to Drugs, Biologicals, and Latex Committee); and the Centers for Disease Control and Prevention Botulism Clinical Treatment Guidelines Workgroup-Allergic Reactions to Botulinum Antitoxin: A Systematic Review. Clin Infect Dis. 2017 Dec 27. 66 (suppl_1):S65-S72. [QxMD MEDLINE Link].

37. Opila T, George A, El-Ghanem M, Souayah N. Trends in Outcomes and Hospitalization Charges of Infant Botulism in the United States: A Comparative Analysis Between Kids' Inpatient Database and National Inpatient Sample. Pediatr Neurol. 2017 Feb. 67:53-58. [QxMD MEDLINE Link].

38. Centers for Disease Control and Prevention. Investigational Heptavalent Botulinum Antitoxin (HBAT) to Replace Licensed Botulinum Antitoxin AB and Investigational Botulinum Antitoxin E. MMWR Morb Mortal Wkly Rep. 2010 Mar 19. 59(10):299. [QxMD MEDLINE Link].

39. Arnon SS. Creation and development of the public service orphan drug Human Botulism Immune Globulin. Pediatrics. 2007 Apr. 119(4):785-9. [QxMD MEDLINE Link].

40. Arnon SS, Schechter R, Maslanka SE, et al. Human botulism immune globulin for the treatment of infant botulism. N Engl J Med. 2006. 354:462-71. [QxMD MEDLINE Link].

41. Chen S, Xu Q, Zeng M. Oral vaccination with an adenovirus-vectored vaccine protects against botulism. Vaccine. 2013 Feb 4. 31(7):1009-11. [QxMD MEDLINE Link].

42. Karalewitz AP, Barbieri JT. Vaccines against botulism. Curr Opin Microbiol. 2012 Jun. 15(3):317-24. [QxMD MEDLINE Link].

43. Rosow LK, Strober JB. Infant botulism: review and clinical update. Pediatr Neurol. 2015 May. 52 (5):487-92. [QxMD MEDLINE Link].

Muhammad Waseem, MBBS, MS, FAAP, FACEP, FAHA Professor of Emergency Medicine and Clinical Pediatrics, Weill Cornell Medical College; Attending Physician, Departments of Emergency Medicine and Pediatrics, Lincoln Medical and Mental Health Center; Adjunct Professor of Emergency Medicine, Adjunct Professor of Pediatrics, St George's University School of Medicine, Grenada

Muhammad Waseem, MBBS, MS, FAAP, FACEP, FAHA is a member of the following medical societies: American Academy of Pediatrics, American Academy of Urgent Care Medicine, American College of Emergency Physicians, American Heart Association, American Medical Association, Association of Clinical Research Professionals, Public Responsibility in Medicine and Research, Society for Academic Emergency Medicine, Society for Simulation in Healthcare

Disclosure: Nothing to disclose.

Joel R Gernsheimer, MD, FACEP Visiting Associate Professor, Department of Emergency Medicine, Attending Physician and Director of Geriatric Emergency Medicine, State University of New York Downstate Medical Center

Joel R Gernsheimer, MD, FACEP is a member of the following medical societies: American College of Emergency Physicians, American Geriatrics Society

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Russell W Steele, MD Clinical Professor, Tulane University School of Medicine; Staff Physician, Ochsner Clinic Foundation

Russell W Steele, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Microbiology, Infectious Diseases Society of America, Louisiana State Medical Society, Pediatric Infectious Diseases Society, Society for Pediatric Research, Southern Medical Association

Disclosure: Nothing to disclose.

Itzhak Brook, MD, MSc Professor, Department of Pediatrics, Georgetown University School of Medicine

Itzhak Brook, MD, MSc is a member of the following medical societies: American Association for the Advancement of Science, American College of Physicians-American Society of Internal Medicine, American Medical Association, American Society for Microbiology, The Society of Federal Health Professionals (AMSUS), Infectious Diseases Society of America, International Immunocompromised Host Society, International Society for Infectious Diseases, Medical Society of the District of Columbia, New York Academy of Sciences, Pediatric Infectious Diseases Society, Society for Experimental Biology and Medicine, Society for Pediatric Research, Southern Medical Association, Society for Ear, Nose and Throat Advances in Children, American Federation for Clinical Research, Surgical Infection Society, Armed Forces Infectious Diseases Society

Disclosure: Nothing to disclose.

Nahed M Abdel-Haq, MD Assistant Professor, Department of Pediatrics, Wayne State University School of Medicine

Nahed M Abdel-Haq, MD is a member of the following medical societies: American Academy of Pediatrics, Infectious Diseases Society of America, and Pediatric Infectious Diseases Society

Disclosure: Nothing to disclose.

Leslie L Barton, MD Professor Emerita of Pediatrics, University of Arizona College of Medicine

Leslie L Barton, MD is a member of the following medical societies: American Academy of Pediatrics, Association of Pediatric Program Directors, Infectious Diseases Society of America, and Pediatric Infectious Diseases Society

Disclosure: Nothing to disclose.

Daniel AC Frattarelli, MD, FAAP Senior Staff, Departments of Pediatrics and Emergency Medicine, Henry Ford Hospital

Daniel AC Frattarelli, MD, FAAP is a member of the following medical societies: American Academy of Pediatrics, American College of Clinical Pharmacology, and American Society for Clinical Pharmacology and Therapeutics

Disclosure: Nothing to disclose.

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