Pediatric Mononucleosis and Epstein-Barr Virus Infection Differential Diagnoses

Updated: Mar 22, 2021
  • Author: Jaya Sureshbabu, MBBS, MRCPCH(UK), MRCPI(Paeds), MRCPS(Glasg), DCH(Glasg); Chief Editor: Russell W Steele, MD  more...
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Diagnostic Considerations

The most widely cited Hoagland’s criteria for the diagnosis of infectious mononucleosis are as follows:

  • At least 50% lymphocytes
  • At least 10% atypical lymphocytes
  • In the presence of fever, pharyngitis, and adenopathy
  • Confirmed by a positive serologic test

Even though these criteria are quite specific, they are not highly sensitive and are most useful for research purposes. Only 50% of patients with symptoms suggestive of infectious mononucleosis and a positive heterophile antibody test meet all of Hoagland’s criteria. [47]


Differential Diagnoses