Ferriero DM. Neonatal brain injury. N Engl J Med. 2004 Nov 4. 351(19):1985-95. [QxMD MEDLINE Link].
Perlman JM. Brain injury in the term infant. Semin Perinatol. 2004 Dec. 28(6):415-24. [QxMD MEDLINE Link].
Grow J, Barks JD. Pathogenesis of hypoxic-ischemic cerebral injury in the term infant: current concepts. Clin Perinatol. 2002 Dec. 29(4):585-602, v. [QxMD MEDLINE Link].
Shankaran S. The postnatal management of the asphyxiated term infant. Clin Perinatol. 2002 Dec. 29(4):675-92. [QxMD MEDLINE Link].
Stola A, Perlman J. Post-resuscitation strategies to avoid ongoing injury following intrapartum hypoxia-ischemia. Semin Fetal Neonatal Med. 2008 Dec. 13(6):424-31. [QxMD MEDLINE Link].
Laptook A, Tyson J, Shankaran S, et al. Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomes. Pediatrics. 2008 Sep. 122(3):491-9. [QxMD MEDLINE Link]. [Full Text].
Shankaran S, Laptook AR, Pappas A, et al, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Effect of depth and duration of cooling on death or disability at age 18 months among neonates with hypoxic-ischemic encephalopathy: a randomized clinical trial. JAMA. 2017 Jul 4. 318(1):57-67. [QxMD MEDLINE Link].
[Guideline] American Academy of Pediatrics. Relation between perinatal factors and neurological outcome. In: Guidelines for Perinatal Care. 3rd ed. Elk Grove Village, Ill: American Academy of Pediatrics; 1992:221-234.
[Guideline] Committee on fetus and newborn, American Academy of Pediatrics and Committee on obstetric practice, American College of Obstetrics and Gynecology. Use and abuse of the APGAR score. Pediatr. 1996. 98:141-2. [QxMD MEDLINE Link].
Papile LA, Rudolph AM, Heymann MA. Autoregulation of cerebral blood flow in the preterm fetal lamb. Pediatr Res. 1985 Feb. 19(2):159-61. [QxMD MEDLINE Link].
Rosenkrantz TS, Diana D, Munson J. Regulation of cerebral blood flow velocity in nonasphyxiated, very low birth weight infants with hyaline membrane disease. J Perinatol. 1988. 8(4):303-8. [QxMD MEDLINE Link].
Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 2007 Jan. 87(1):315-424. [QxMD MEDLINE Link].
Roth SC, Baudin J, Cady E, Johal K, Townsend JP, Wyatt JS. Relation of deranged neonatal cerebral oxidative metabolism with neurodevelopmental outcome and head circumference at 4 years. Dev Med Child Neurol. 1997 Nov. 39(11):718-25. [QxMD MEDLINE Link].
Berger R, Garnier Y. Pathophysiology of perinatal brain damage. Brain Res Brain Res Rev. 1999 Aug. 30(2):107-34. [QxMD MEDLINE Link].
Rivkin MJ. Hypoxic-ischemic brain injury in the term newborn. Neuropathology, clinical aspects, and neuroimaging. Clin Perinatol. 1997 Sep. 24(3):607-25. [QxMD MEDLINE Link].
Vannucci RC. Mechanisms of perinatal hypoxic-ischemic brain damage. Semin Perinatol. 1993 Oct. 17(5):330-7. [QxMD MEDLINE Link].
Vannucci RC, Yager JY, Vannucci SJ. Cerebral glucose and energy utilization during the evolution of hypoxic-ischemic brain damage in the immature rat. J Cereb Blood Flow Metab. 1994 Mar. 14(2):279-88. [QxMD MEDLINE Link].
de Haan HH, Hasaart TH. Neuronal death after perinatal asphyxia. Eur J Obstet Gynecol Reprod Biol. 1995 Aug. 61(2):123-7. [QxMD MEDLINE Link].
McLean C, Ferriero D. Mechanisms of hypoxic-ischemic injury in the term infant. Semin Perinatol. 2004 Dec. 28(6):425-32. [QxMD MEDLINE Link].
Badawi N, Kurinczuk JJ, Keogh JM, et al. Antepartum risk factors for newborn encephalopathy: the Western Australian case-control study. British Medical Journal. 1998. 317:1549-53. [QxMD MEDLINE Link].
Graham EM, Ruis KA, Hartman AL, Northington FJ, Fox HE. A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy. Am J Obstet Gynecol. 2008 Dec. 199(6):587-95. [QxMD MEDLINE Link].
Bryce J, Boschi-Pinto C, Shibuya K, Black RE. WHO estimates of the causes of death in children. Lancet. 2005 Mar 26-Apr 1. 365(9465):1147-52. [QxMD MEDLINE Link].
Lawn J, Shibuya K, Stein C. No cry at birth: global estimates of intrapartum stillbirths and intrapartum-related neonatal deaths. Bull World Health Organ. 2005 Jun. 83(6):409-17. [QxMD MEDLINE Link]. [Full Text].
Patel J, Edwards AD. Prediction of outcome after perinatal asphyxia. Curr Opin Pediatr. 1997 Apr. 9(2):128-32. [QxMD MEDLINE Link].
Gunn AJ, Wyatt JS, Whitelaw A, et al. Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy. J Pediatr. 2008 Jan. 152(1):55-8, 58.e1. [QxMD MEDLINE Link].
Massaro AN, Chang T, Kadom N, et al. Biomarkers of brain injury in neonatal encephalopathy treated with hypothermia. J Pediatr. 2012 Sep. 161(3):434-40. [QxMD MEDLINE Link].
Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet. 2005 Feb 19-25. 365(9460):663-70. [QxMD MEDLINE Link].
Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005 Oct 13. 353(15):1574-84. [QxMD MEDLINE Link].
Pappas A, Shankaran S, Laptook AR, et al, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Hypocarbia and adverse outcome in neonatal hypoxic-ischemic encephalopathy. J Pediatr. 2011 May. 158(5):752-758.e1. [QxMD MEDLINE Link].
van Handel M, Swaab H, de Vries LS, Jongmans MJ. Long-term cognitive and behavioral consequences of neonatal encephalopathy following perinatal asphyxia: a review. Eur J Pediatr. 2007 Jul. 166(7):645-54. [QxMD MEDLINE Link].
Pin TW, Eldridge B, Galea MP. A review of developmental outcomes of term infants with post-asphyxia neonatal encephalopathy. Eur J Paediatr Neurol. 2009 May. 13(3):224-34. [QxMD MEDLINE Link].
Simon NP. Long-term neurodevelopmental outcome of asphyxiated newborns. Clin Perinatol. 1999 Sep. 26(3):767-78. [QxMD MEDLINE Link].
Martin-Ancel A, Garcia-Alix A, Gaya F, Cabanas F, Burgueros M, Quero J. Multiple organ involvement in perinatal asphyxia. J Pediatr. 1995 Nov. 127(5):786-93. [QxMD MEDLINE Link].
Shah P, Riphagen S, Beyene J, Perlman M. Multiorgan dysfunction in infants with post-asphyxial hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2004. 89:F152-F155. [QxMD MEDLINE Link].
Mizrahi EM, Kellaway P. Characterization and classification of neonatal seizures. Neurology. 1987 Dec. 37(12):1837-44. [QxMD MEDLINE Link].
Hahn JS, Olson DM. Etiology of neonatal seizures. NeoReviews. 2004 Aug. 5(8):e327. [Full Text].
Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol. 1976 Oct. 33(10):696-705. [QxMD MEDLINE Link].
Enns, GM. Inborn errors of metabolism masquerading as hypoxic-ischemic encephalopathy. Neoreviews. 2005. 6(12):e549-e558. [Full Text].
Hobson EE, Thomas S, Crofton PM, Murray AD, Dean JC, Lloyd D. Isolated sulphite oxidase deficiency mimics the features of hypoxic ischaemic encephalopathy. Eur J Pediatr. 2005 Nov. 164(11):655-9. [QxMD MEDLINE Link].
Shastri AT, Samarasekara S, Muniraman H, Clarke P. Cardiac troponin I concentrations in neonates with hypoxic-ischaemic encephalopathy. Acta Paediatr. 2012 Jan. 101(1):26-9. [QxMD MEDLINE Link].
Huang BY, Castillo M. Hypoxic-ischemic brain injury: imaging findings from birth to adulthood. Radiographics. 2008 Mar-Apr. 28(2):417-39; quiz 617. [QxMD MEDLINE Link].
Latchaw RE, Truwit CE. Imaging of perinatal hypoxic-ischemic brain injury. Semin Pediatr Neurol. 1995 Mar. 2(1):72-89. [QxMD MEDLINE Link].
Rutherford M, Pennock J, Schwieso J, Cowan F, Dubowitz L. Hypoxic-ischaemic encephalopathy: early and late magnetic resonance imaging findings in relation to outcome. Arch Dis Child Fetal Neonatal Ed. 1996. 75:F145-F151. [QxMD MEDLINE Link].
Rutherford M, Biarge MM, Allsop J, Counsell S, Cowan F. MRI of perinatal brain injury. Pediatr Radiol. 2010. 40(6):819-33. [QxMD MEDLINE Link].
Cowan FM, de Vries LS. The internal capsule in neonatal imaging. Semin Fetal Neonatal Med. 2005 Oct. 10(5):461-74. [QxMD MEDLINE Link].
Martinez-Biarge M, Diez-Sebastian J, Kapellou O, et al. Predicting motor outcome and death in term hypoxic-ischemic encephalopathy. Neurology. 2011 Jun 14. 76(24):2055-61. [QxMD MEDLINE Link]. [Full Text].
Kidokoro H, Anderson PJ, Doyle LW, Woodward LJ, Neil JJ, Inder TE. Brain injury and altered brain growth in preterm infants: predictors and prognosis. Pediatrics. 2014 Aug. 134(2):e444-53. [QxMD MEDLINE Link].
Cheong JL, Coleman L, Hunt RW, et al, for the Infant Cooling Evaluation Collaboration. Prognostic utility of magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy: substudy of a randomized trial. Arch Pediatr Adolesc Med. 2012. 7:634-40. [QxMD MEDLINE Link].
Pinto PS, Tekes A, Singhi S, Northington FJ, Parkinson C, Huisman TA. White-gray matter echogenicity ratio and resistive index: sonographic bedside markers of cerebral hypoxic-ischemic injury/edema?. J Perinatol. 2012. 32:448-53. [QxMD MEDLINE Link].
Gerner GJ, Burton VJ, Poretti A, et al. Transfontanellar duplex brain ultrasonography resistive indices as a prognostic tool in neonatal hypoxic-ischemic encephalopathy before and after treatment with therapeutic hypothermia. J Perinatol. 2016. 36:202-6. [QxMD MEDLINE Link].
Brenner DJ. Estimating cancer risks from pediatric CT: going from the qualitative to the quantitative. Pediatr Radiol. 2002 Apr. 32(4):228-1; discussion 242-4. [QxMD MEDLINE Link].
Pearce MS, Salotti JA, Little MP, et al. Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet. 2012. 380(9840):499-505. [QxMD MEDLINE Link].
Brenner DJ, Hall EJ. Computed tomography--an increasing source of radiation exposure. N Engl J Med. 2007 Nov 29. 357(22):2277-84. [QxMD MEDLINE Link].
Barkovich AJ. The encephalopathic neonate: choosing the proper imaging technique. AJNR Am J Neuroradiol. 1997 Nov-Dec. 18(10):1816-20. [QxMD MEDLINE Link].
de Vries LS, Toet MC. Amplitude integrated electroencephalography in the full-term newborn. Clin Perinatol. 2006 Sep. 33(3):619-32, vi. [QxMD MEDLINE Link].
Hellstrom-Westas L, Rosen I. Continuous brain-function monitoring: state of the art in clinical practice. Semin Fetal Neonatal Med. 2006 Dec. 11(6):503-11. [QxMD MEDLINE Link].
van Rooij LGM, Toet MC, Osredkar D, van Huffelen AC, Groenendaal F, de Vries LS. Recovery of amplitude integrated electroencephalographic background patterns within 24 hours of perinatal asphyxia. Arch. Dis. Child. Fetal Neonatal Ed. 2005. 90:F245-F251. [QxMD MEDLINE Link].
Jacobs S, Hunt R, Tarnow-Mordi W, Inder T, Davis P. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2007. 4:CD003311. [QxMD MEDLINE Link].
Spitzmiller RE, Phillips T, Meinzen-Derr J, Hoath SB. Amplitude-integrated EEG is useful in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischemic encephalopathy: a meta-analysis. J Child Neurol. 2007 Sep. 22(9):1069-78. [QxMD MEDLINE Link].
Pressler RM, Boylan GB, Morton M, Binnie CD, Rennie JM. Early serial EEG in hypoxic ischaemic encephalopathy. Clin Neurophysiol. 2001 Jan. 112(1):31-7. [QxMD MEDLINE Link].
Rowe JC, Holmes GL, Hafford J, et al. Prognostic value of the electroencephalogram in term and preterm infants following neonatal seizures. Electroencephalogr Clin Neurophysiol. 1985 Mar. 60(3):183-96. [QxMD MEDLINE Link].
Volpe JJ. Hypoxic-ischemic encephalopathy: clinical aspects. Neurology of the Newborn. 5th ed. Philadelphia, PA: Saunders-Elsevier; 2008. chapter 9.
Murray DM, Boylan GB, Ryan CA, Connolly S. Early EEG findings in hypoxic-ischemic encephalopathy predict outcomes at 2 years. Pediatrics. 2009 Sep. 124(3):e459-67. [QxMD MEDLINE Link].
Sinclair DB, Campbell M, Byrne P, Prasertsom W, Robertson CM. EEG and long-term outcome of term infants with neonatal hypoxic-ischemic encephalopathy. Clin Neurophysiol. 1999 Apr. 110(4):655-9. [QxMD MEDLINE Link].
Tong AY, El-Dairi M, Maldonado RS, et al. Evaluation of optic nerve development in preterm and term infants using handheld spectral-domain optical coherence tomography. Ophthalmology. 2014 Sep. 121(9):1818-26. [QxMD MEDLINE Link]. [Full Text].
Perlman JM. Intervention strategies for neonatal hypoxic-ischemic cerebral injury. Clin Ther. 2006 Sep. 28(9):1353-65. [QxMD MEDLINE Link].
[Guideline] Biban P, Filipovic-Grcic B, Biarent D, Manzoni P; International Liaison Committee on Resuscitation (ILCOR); European Resuscitation Council (ERC); American Heart Association (AHA); American Academy of Pediatrics (AAP). New cardiopulmonary resuscitation guidelines 2010: managing the newly born in delivery room. Early Hum Dev. 2011. 87 (suppl 1):S9-11. [QxMD MEDLINE Link].
[Guideline] Kattwinkel J, Perlman JM, Aziz K, et al, for the American Heart Association. Neonatal resuscitation: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Pediatrics. 2010 Nov. 126(5):e1400-13. [QxMD MEDLINE Link].
Sabir H, Jary S, Tooley J, Liu X, Thoresen M. Increased inspired oxygen in the first hours of life is associated with adverse outcome in newborns treated for perinatal asphyxia with therapeutic hypothermia. J Pediatr. 2012 Sep. 161(3):409-16. [QxMD MEDLINE Link].
[Guideline] American Academy of Pediatrics. Committee on Fetus and Newborn. Use of inhaled nitric oxide. Pediatrics. 2000 Aug. 106(2 Pt 1):344-5. [QxMD MEDLINE Link].
Kecskes Z, Healy G, Jensen A. Fluid restriction for term infants with hypoxic-ischaemic encephalopathy following perinatal asphyxia. Cochrane Database Syst Rev. 2005 Jul 20. CD004337. [QxMD MEDLINE Link].
Bakr AF. Prophylactic theophylline to prevent renal dysfunction in newborns exposed to perinatal asphyxia--a study in a developing country. Pediatr Nephrol. 2005 Sep. 20(9):1249-52. [QxMD MEDLINE Link].
Bhat MA, Shah ZA, Makhdoomi MS, Mufti MH. Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. J Pediatr. 2006 Aug. 149(2):180-4. [QxMD MEDLINE Link].
Jenik AG, Ceriani Cernadas JM, Gorenstein A, et al. A randomized, double-blind, placebo-controlled trial of the effects of prophylactic theophylline on renal function in term neonates with perinatal asphyxia. Pediatrics. 2000 Apr. 105(4):E45. [QxMD MEDLINE Link].
Salhab WA, Wyckoff MH, Laptook AR, Perlman JM. Initial hypoglycemia and neonatal brain injury in term infants with severe fetal acidemia. Pediatrics. 2004 Aug. 114(2):361-6. [QxMD MEDLINE Link].
Miller SP, Weiss J, Barnwell A, et al. Seizure-associated brain injury in term newborns with perinatal asphyxia. Neurology. 2002 Feb 26. 58(4):542-8. [QxMD MEDLINE Link].
Scher MS. Neonatal seizures and brain damage. Pediatr Neurol. 2003 Nov. 29(5):381-90. [QxMD MEDLINE Link].
Holmes GL. Effects of seizures on brain development: lessons from the laboratory. Pediatr Neurol. 2005 Jul. 33(1):1-11. [QxMD MEDLINE Link].
Boylan GB, Rennie JM, Chorley G, et al. Second-line anticonvulsant treatment of neonatal seizures: a video-EEG monitoring study. Neurology. 2004 Feb 10. 62(3):486-8. [QxMD MEDLINE Link].
Boylan GB, Rennie JM, Pressler RM, Wilson G, Morton M, Binnie CD. Phenobarbitone, neonatal seizures, and video-EEG. Arch Dis Child Fetal Neonatal Ed. 2002 May. 86(3):F165-70. [QxMD MEDLINE Link].
Painter MJ, Scher MS, Stein AD, et al. Phenobarbital compared with phenytoin for the treatment of neonatal seizures. N Engl J Med. 1999 Aug 12. 341(7):485-9. [QxMD MEDLINE Link].
Castro Conde JR, Hernandez Borges AA, Domenech Martinez E, Gonzalez Campo C, Perera Soler R. Midazolam in neonatal seizures with no response to phenobarbital. Neurology. 2005 Mar 8. 64(5):876-9. [QxMD MEDLINE Link].
Maytal J, Novak GP, King KC. Lorazepam in the treatment of refractory neonatal seizures. J Child Neurol. 1991 Oct. 6(4):319-23. [QxMD MEDLINE Link].
Gunn AJ, Gunn TR. The 'pharmacology' of neuronal rescue with cerebral hypothermia. Early Hum Dev. 1998 Nov. 53(1):19-35. [QxMD MEDLINE Link].
Gunn AJ. Cerebral hypothermia for prevention of brain injury following perinatal asphyxia. Curr Opin Pediatr. 2000 Apr. 12(2):111-5. [QxMD MEDLINE Link].
Eicher DJ, Wagner CL, Katikaneni LP, et al. Moderate hypothermia in neonatal encephalopathy: safety outcomes. Pediatr Neurol. 2005. 32(1):18-24. [QxMD MEDLINE Link].
Eicher DJ, Wagner CL, Katikaneni LP, et al. Moderate hypothermia in neonatal encephalopathy: efficacy outcomes. Pediatr Neurol. 2005 Jan. 32(1):11-7. [QxMD MEDLINE Link].
Jacobs SE, Morley CJ, Inder TE, et al, for the Infant Cooling Evaluation Collaboration. Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial. Arch Pediatr Adolesc Med. 2011 Aug. 165(8):692-700. [QxMD MEDLINE Link].
Zhou WH, Cheng GQ, Shao XM, et al. Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a multicenter randomized controlled trial in China. J Pediatr. 2010 Sep. 157(3):367-72, 372.e1-3. [QxMD MEDLINE Link].
Simbruner G, Mittal RA, Rohlmann F, Muche R. Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO.network RCT. Pediatrics. 2010 Oct. 126(4):e771-8. [QxMD MEDLINE Link].
Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med. 2009 Oct 1. 361(14):1349-58. [QxMD MEDLINE Link].
Shankaran S, Pappas A, Laptook AR, et al. Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy. Pediatrics. 2008 Oct. 122(4):e791-8. [QxMD MEDLINE Link]. [Full Text].
Shankaran S, Pappas A, McDonald SA, et al. Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med. 2012 May 31. 366(22):2085-92. [QxMD MEDLINE Link].
Azzopardi D, Strohm B, Marlow N,et al, for the TOBY Study Group. Effects of hypothermia for perinatal asphyxia on childhood outcomes. N Engl J Med. 2014 Jul 10. 371(2):140-9. [QxMD MEDLINE Link].
Laptook AR. Use of therapeutic hypothermia for term infants with hypoxic-ischemic encephalopathy. Pediatr Clin North Am. 2009 Jun. 56(3):601-16, Table of Contents. [QxMD MEDLINE Link].
Shankaran S. Neonatal encephalopathy: treatment with hypothermia. J Neurotrauma. 2009 Mar. 26(3):437-43. [QxMD MEDLINE Link]. [Full Text].
Fairchild K, Sokora D, Scott J, Zanelli S. Therapeutic hypothermia on neonatal transport: 4-year experience in a single NICU. J Perinatol. 2010 May. 30(5):324-9. [QxMD MEDLINE Link].
Shankaran S, Laptook AR, Pappas A, et al, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy: a randomized clinical trial. JAMA. 2014 Dec 24-31. 312(24):2629-39. [QxMD MEDLINE Link].
Zanelli SA, Naylor M, Dobbins N, et al. Implementation of a 'Hypothermia for HIE' program: 2-year experience in a single NICU. J Perinatol. 2008 Mar. 28(3):171-5. [QxMD MEDLINE Link].
Vannucci RC, Perlman JM. Interventions for perinatal hypoxic-ischemic encephalopathy. Pediatrics. 1997 Dec. 100(6):1004-14. [QxMD MEDLINE Link].
Hall RT, Hall FK, Daily DK. High-dose phenobarbital therapy in term newborn infants with severe perinatal asphyxia: a randomized, prospective study with three-year follow-up. J Pediatr. 1998 Feb. 132(2):345-8. [QxMD MEDLINE Link].
Goldberg RN, Moscoso P, Bauer CR, et al. Use of barbiturate therapy in severe perinatal asphyxia: a randomized controlled trial. J Pediatr. 1986 Nov. 109(5):851-6. [QxMD MEDLINE Link].
Evans DJ, Levene MI, Tsakmakis M. Anticonvulsants for preventing mortality and morbidity in full term newborns with perinatal asphyxia. Cochrane Database Syst Rev. 2007 Jul 18. CD001240. [QxMD MEDLINE Link].
Zhu C, Kang W, Xu F, et al. Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy. Pediatrics. 2009 Aug. 124(2):e218-26. [QxMD MEDLINE Link].
Van Bel F, Shadid M, Moison RM, et al. Effect of allopurinol on postasphyxial free radical formation, cerebral hemodynamics, and electrical brain activity. Pediatrics. 1998 Feb. 101(2):185-93. [QxMD MEDLINE Link]. [Full Text].
Cotten CM, Murtha AP, Goldberg RN, et al. Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy. J Pediatr. 2014 May. 164(5):973-979.e1. [QxMD MEDLINE Link].
Gonzales-Portillo GS, Reyes S, Aguirre D, Pabon MM, Borlongan CV. Stem cell therapy for neonatal hypoxic-ischemic encephalopathy. Front Neurol. 2014 Aug 12. 5:147. [QxMD MEDLINE Link].
Mitsialis SA, Kourembanas S. Stem cell-based therapies for the newborn lung and brain: Possibilities and challenges. Semin Perinatol. 2016 Apr. 40(3):138-51. [QxMD MEDLINE Link].
Thyagarajan B, Tillqvist E, Baral V, Hallberg B, Vollmer B, Blennow M. Minimal enteral nutrition during neonatal hypothermia treatment for perinatal hypoxic-ischaemic encephalopathy is safe and feasible. Acta Paediatr. 2015 Feb. 104(2):146-51. [QxMD MEDLINE Link].
Depp R. Perinatal asphyxia: assessing its causal role and timing. Semin Pediatr Neurol. 1995 Mar. 2(1):3-36. [QxMD MEDLINE Link].
Robertson CM, Perlman M. Follow-up of the term infant after hypoxic-ischemic encephalopathy. Paediatr Child Health. 2006 May. 11(5):278-82. [QxMD MEDLINE Link]. [Full Text].
Edwards AD, Azzopardi DV. Therapeutic hypothermia following perinatal asphyxia. Arch Dis Child Fetal Neonatal ed. 2006. 91:F127-F131. [QxMD MEDLINE Link].
Guillet R, Edwards AD, Thoresen M, et al, for the CoolCap Trial Group. Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy. Pediatr Res. 2012 Feb. 71(2):205-9. [QxMD MEDLINE Link].
Gunn AJ, Gunn TR, de Haan HH, Williams CE, Gluckman PD. Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs. J Clin Invest. 1997 Jan 15. 99(2):248-56. [QxMD MEDLINE Link].
Gunn AJ, Hoehn T, Hansmann G, et al. Hypothermia: an evolving treatment for neonatal hypoxic ischemic encephalopathy. Pediatrics. 2008 Mar. 121(3):648-9; author reply 649-50. [QxMD MEDLINE Link].
Hull J, Dodd KL. Falling incidence of hypoxic-ischaemic encephalopathy in term infants. Br J Obstet Gynaecol. 1992 May. 99(5):386-91. [QxMD MEDLINE Link].
Perlman M, Shah PS. Ethics of therapeutic hypothermia. Acta Paediatr. 2009 Feb. 98(2):211-3. [QxMD MEDLINE Link].
Schulzke SM, Rao S, Patole SK. A systematic review of cooling for neuroprotection in neonates with hypoxic ischemic encephalopathy - are we there yet?. BMC Pediatr. 2007 Sep 5. 7:30. [QxMD MEDLINE Link].
Shah PS, Ohlsson A, Perlman M. Hypothermia to treat neonatal hypoxic ischemic encephalopathy: systematic review. Arch Pediatr Adolesc Med. 2007 Oct. 161(10):951-8. [QxMD MEDLINE Link].
Shankaran S, Pappas A, McDonald SA, et al, for the Eunice Kennedy Shriver NICHD Neonatal Research Network. Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med. 2012 May 31. 366(22):2085-92. [QxMD MEDLINE Link].
Smith J, Wells L, Dodd K. The continuing fall in incidence of hypoxic-ischaemic encephalopathy in term infants. BJOG. 2000 Apr. 107(4):461-6. [QxMD MEDLINE Link].
Srinivasakumar P, Zempel J, Wallendorf M, Lawrence R, Inder T, Mathur A. Therapeutic hypothermia in neonatal hypoxic ischemic encephalopathy: electrographic seizures and magnetic resonance imaging evidence of injury. J Pediatr. 2013 Aug. 163(2):465-70. [QxMD MEDLINE Link].
[Guideline] Ten VS, Matsiukevich D. Room air or 100% oxygen for resuscitation of infants with perinatal depression. Curr Opin Pediatr. 2009 Apr. 21(2):188-93. [QxMD MEDLINE Link].
Wilkinson DJ. Cool heads: ethical issues associated with therapeutic hypothermia for newborns. Acta Paediatr. 2009 Feb. 98(2):217-20. [QxMD MEDLINE Link].
Yoon JH, Lee EJ, Yum SK, et al. Impacts of therapeutic hypothermia on cardiovascular hemodynamics in newborns with hypoxic-ischemic encephalopathy: a case control study using echocardiography. J Matern Fetal Neonatal Med. 2018 Aug. 31 (16):2175-82. [QxMD MEDLINE Link].
McNamara K, O'Donoghue K, Greene RA. Intrapartum fetal deaths and unexpected neonatal deaths in the Republic of Ireland: 2011 - 2014; a descriptive study. BMC Pregnancy Childbirth. 2018 Jan 4. 18(1):9. [QxMD MEDLINE Link]. [Full Text].
Chiang MC, Jong YJ, Lin CH. Therapeutic hypothermia for neonates with hypoxic ischemic encephalopathy. Pediatr Neonatol. 2017 Dec. 58 (6):475-83. [QxMD MEDLINE Link]. [Full Text].
Thyagarajan B, Baral V, Gunda R, Hart D, Leppard L, Vollmer B. Parental perceptions of hypothermia treatment for neonatal hypoxic-ischaemic encephalopathy. J Matern Fetal Neonatal Med. 2018 Oct. 31 (19):2527-33. [QxMD MEDLINE Link].
Choi DW, Park JH, Lee SY, An SH. Effect of hypothermia treatment on gentamicin pharmacokinetics in neonates with hypoxic-ischaemic encephalopathy: A systematic review and meta-analysis. J Clin Pharm Ther. 2018 Aug. 43 (4):484-92. [QxMD MEDLINE Link].
Liljestrom L, Wikstrom AK, Jonsson M. Obstetric emergencies as antecedents to neonatal hypoxic ischemic encephalopathy, does parity matter?. Acta Obstet Gynecol Scand. 2018 Jul 6. [QxMD MEDLINE Link].