Pulmonary Interstitial Emphysema Questions & Answers

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3. Toledo Del Castillo B, Gordillo I, et al. Diffuse persistent pulmonary interstitial emphysema secondary to mechanical ventilation in bronchiolitis. BMC Pulm Med. 2016 Nov 3. 16(1):139. [QxMD MEDLINE Link].

4. Kim C, Shin JE, Lee SM, et al. A case of pulmonary interstitial emphysema treated by percutaneous catheter insertion in extremely low birth weight infant. Yonsei Med J. 2016 Nov. 57(6):1523-6. [QxMD MEDLINE Link].

5. Nunez-Ramiro A, Aguar M, Cernada M, Parra-Llorca A, Vento M. Oxygen needs during resuscitation and surfactant to achieve stabilisation were independent risks factors for pulmonary interstitial emphysema in preterm infants. Acta Paediatr. 2018 Jan. 107(1):28-32. [QxMD MEDLINE Link].

6. Freysdottir D, Olutoye O, Langston C, Fernandes CJ, Tatevian N. Spontaneous pulmonary interstitial emphysema in a term unventilated infant. Pediatr Pulmonol. 2006 Apr. 41(4):374-8. [QxMD MEDLINE Link].

7. Berk DR, Varich LJ. Localized persistent pulmonary interstitial emphysema in a preterm infant in the absence of mechanical ventilation. Pediatr Radiol. 2005 Dec. 35(12):1243-5. [QxMD MEDLINE Link].

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9. Gronbach J, Ehrhardt H, Zimmer KP, Waitz M. Early pulmonary interstitial emphysema in preterm neonates-respiratory management and case report in nonventilated very low birth weight twins. AJP Rep. 2018 Apr. 8(2):e99-e105. [QxMD MEDLINE Link]. [Full Text].

10. Mahapatra S, Scottoline B. Steroid-induced resolution of refractory pulmonary interstitial emphysema. J Matern Fetal Neonatal Med. 2016 Dec. 29(24):4092-5. [QxMD MEDLINE Link].

11. Heneghan MA, Sosulski R, Alarcon MB. Early pulmonary interstitial emphysema in the newborn: a grave prognostic sign. Clin Pediatr (Phila). 1987 Jul. 26(7):361-5. [QxMD MEDLINE Link].

12. Aiyoshi T, Masumoto K, Shinkai T, et al. Pulmonary interstitial emphysema due to respiratory syncytial virus infection. Pediatr Int. 2016 Sep. 58(9):916-9. [QxMD MEDLINE Link].

13. Wyszogrodski I, Kyei-Aboagye K, Taeusch HW Jr, Avery ME. Surfactant inactivation by hyperventilation: conservation by end-expiratory pressure. J Appl Physiol. 1975 Mar. 38(3):461-6. [QxMD MEDLINE Link].

14. Thayyil S, Nagakumar P, Gowers H, Sinha A. Optimal endotracheal tube tip position in extremely premature infants. Am J Perinatol. 2008 Jan. 25(1):13-6. [QxMD MEDLINE Link].

15. Plenat F, Vert P, Didier F, Andre M. Pulmonary interstitial emphysema. Clin Perinatol. 1978 Sep. 5(2):351-75. [QxMD MEDLINE Link].

16. Wood BP, Anderson VM, Mauk JE, Merritt TA. Pulmonary lymphatic air: locating "pulmonary interstitial emphysema" of the premature infant. AJR Am J Roentgenol. 1982 May. 138(5):809-14. [QxMD MEDLINE Link].

17. Cunningham K, Paes BA, Symington A. Pulmonary interstitial emphysema: a review. Neonatal Netw. 1992 Aug. 11(5):7-16, 29-31. [QxMD MEDLINE Link].

18. Verma RP, Chandra S, Niwas R, Komaroff E. Risk factors and clinical outcomes of pulmonary interstitial emphysema in extremely low birth weight infants. J Perinatol. 2006 Mar. 26(3):197-200. [QxMD MEDLINE Link].

19. Perea L, Blinman T, Piccione J, Laje P. Bilateral congenital lobar emphysema: staged management. J Pediatr Surg. 2017 Sep. 52(9):1442-5. [QxMD MEDLINE Link].

20. Gaylord MS, Thieme RE, Woodall DL, Quissell BJ. Predicting mortality in low-birth-weight infants with pulmonary interstitial emphysema. Pediatrics. 1985 Aug. 76(2):219-24. [QxMD MEDLINE Link].

21. Kendig JW, Notter RH, Cox C, et al. Surfactant replacement therapy at birth: final analysis of a clinical trial and comparisons with similar trials. Pediatrics. 1988 Nov. 82(5):756-62. [QxMD MEDLINE Link].

22. Dunn MS, Shennan AT, Zayack D, Possmayer F. Bovine surfactant replacement therapy in neonates of less than 30 weeks' gestation: a randomized controlled trial of prophylaxis versus treatment. Pediatrics. 1991 Mar. 87(3):377-86. [QxMD MEDLINE Link].

23. Kattwinkel J, Bloom BT, Delmore P, et al. Prophylactic administration of calf lung surfactant extract is more effective than early treatment of respiratory distress syndrome in neonates of 29 through 32 weeks' gestation. Pediatrics. 1993 Jul. 92(1):90-8. [QxMD MEDLINE Link].

24. Moriette G, Paris-Llado J, Walti H, et al. Prospective randomized multicenter comparison of high-frequency oscillatory ventilation and conventional ventilation in preterm infants of less than 30 weeks with respiratory distress syndrome. Pediatrics. 2001 Feb. 107(2):363-72. [QxMD MEDLINE Link]. [Full Text].

25. Hart SM, McNair M, Gamsu HR, Price JF. Pulmonary interstitial emphysema in very low birthweight infants. Arch Dis Child. 1983 Aug. 58(8):612-5. [QxMD MEDLINE Link].

26. Amini E, Nayeri FS, Hemati A, et al. Comparison of high frequency positive pressure mechanical ventilation (HFPPV) with conventional method in the treatment of neonatal respiratory failure. Iran Red Crescent Med J. 2013 Mar. 15(3):183-6. [QxMD MEDLINE Link].

27. Yu VY, Wong PY, Bajuk B, Szymonowicz W. Pulmonary interstitial emphysema in infants less than 1000 g at birth. Aust Paediatr J. 1986 Aug. 22(3):189-92. [QxMD MEDLINE Link].

28. Morisot C, Kacet N, Bouchez MC, et al. Risk factors for fatal pulmonary interstitial emphysema in neonates. Eur J Pediatr. 1990 Apr. 149(7):493-5. [QxMD MEDLINE Link].

29. Campbell RE. Intrapulmonary interstitial emphysema: a complication of hyaline membrane disease. Am J Roentgenol Radium Ther Nucl Med. 1970 Nov. 110(3):449-56. [QxMD MEDLINE Link].

30. Jabra AA, Fishman EK, Shehata BM, Perlman EJ. Localized persistent pulmonary interstitial emphysema: CT findings with radiographic-pathologic correlation. AJR Am J Roentgenol. 1997 Nov. 169(5):1381-4. [QxMD MEDLINE Link].

31. Schwartz AN, Graham CB. Neonatal tension pulmonary interstitial emphysema in bronchopulmonary dysplasia: treatment with lateral decubitus positioning. Radiology. 1986 Nov. 161(2):351-4. [QxMD MEDLINE Link].

32. Brooks JG, Bustamante SA, Koops BL, et al. Selective bronchial intubation for the treatment of severe localized pulmonary interstitial emphysema in newborn infants. J Pediatr. 1977 Oct. 91(4):648-52. [QxMD MEDLINE Link].

33. Chalak LF, Kaiser JR, Arrington RW. Resolution of pulmonary interstitial emphysema following selective left main stem intubation in a premature newborn: an old procedure revisited. Paediatr Anaesth. 2007 Feb. 17(2):183-6. [QxMD MEDLINE Link].

34. Weintraub Z, Oliven A, Weissman D, Sonis Z. A new method for selective left main bronchus intubation in premature infants. J Pediatr Surg. 1990 Jun. 25(6):604-6. [QxMD MEDLINE Link].

35. Keszler M, Donn SM, Bucciarelli RL, et al. Multicenter controlled trial comparing high-frequency jet ventilation and conventional mechanical ventilation in newborn infants with pulmonary interstitial emphysema. J Pediatr. 1991 Jul. 119(1 Pt 1):85-93. [QxMD MEDLINE Link].

36. Clark RH, Gerstmann DR, Null DM, et al. Pulmonary interstitial emphysema treated by high-frequency oscillatory ventilation. Crit Care Med. 1986 Nov. 14(11):926-30. [QxMD MEDLINE Link].

37. Squires KA, De Paoli AG, Williams C, Dargaville PA. High-frequency oscillatory ventilation with low oscillatory frequency in pulmonary interstitial emphysema. Neonatology. 2013. 104(4):243-9. [QxMD MEDLINE Link].

38. Ahluwalia JS, Rennie JM, Wells FC. Successful outcome of severe unilateral pulmonary interstitial emphysema after bi-lobectomy in a very low birthweight infant. J R Soc Med. 1996 Mar. 89(3):167P-8P. [QxMD MEDLINE Link]. [Full Text].

39. Gessler P, Toenz M, Gugger M, Pfenninger J. Lobar pulmonary interstitial emphysema in a premature infant on continuous positive airway pressure using nasal prongs. Eur J Pediatr. 2001 Apr. 160(4):263-4. [QxMD MEDLINE Link].

40. Martinez-Frontanilla LA, Hernandez J, Haase GM, Burrington JD. Surgery of acquired lobar emphysema in the neonate. J Pediatr Surg. 1984 Aug. 19(4):375-9. [QxMD MEDLINE Link].

41. Jassal MS, Benson JE, Mogayzel PJ Jr. Spontaneous resolution of diffuse persistent pulmonary interstitial emphysema. Pediatr Pulmonol. 2008 Jun. 43(6):615-9. [QxMD MEDLINE Link].

42. Fitzgerald D, Willis D, Usher R, Outerbridge E, Davis GM. Dexamethasone for pulmonary interstitial emphysema in preterm infants. Biol Neonate. 1998. 73(1):34-9. [QxMD MEDLINE Link].

43. Leonidas JC, Hall RT, Rhodes PG. Conservative management of unilateral pulmonary interstitial emphysema under tension. J Pediatr. 1975 Nov. 87(5):776-8. [QxMD MEDLINE Link].

44. Dear PR, Conway SP. Treatment of severe bilateral interstitial emphysema in a baby by artificial pneumothorax and pneumonotomy. Lancet. 1984 Feb 4. 1(8371):273-5. [QxMD MEDLINE Link].

45. Dordelmann M, Schirg E, Poets CF, Ure B, Gluer S, Bohnhorst B. Therapeutic lung puncture for diffuse unilateral pulmonary interstitial emphysema in preterm infants. Eur J Pediatr Surg. 2008 Aug. 18(4):233-6. [QxMD MEDLINE Link].

46. Levine DH, Trump DS, Waterkotte G. Unilateral pulmonary interstitial emphysema: a surgical approach to treatment. Pediatrics. 1981 Oct. 68(4):510-4. [QxMD MEDLINE Link].

47. Phatak RS, Pairaudeau CF, Smith CJ, Pairaudeau PW, Klonin H. Heliox with inhaled nitric oxide: a novel strategy for severe localized interstitial pulmonary emphysema in preterm neonatal ventilation. Respir Care. 2008 Dec. 53(12):1731-8. [QxMD MEDLINE Link].

48. Soll RF, Morley CJ. Prophylactic versus selective use of surfactant in preventing morbidity and mortality in preterm infants. Cochrane Database Syst Rev. 2001. CD000510. [QxMD MEDLINE Link].

49. Stevens TP, Harrington EW, Blennow M, Soll RF. Early surfactant administration with brief ventilation vs. selective surfactant and continued mechanical ventilation for preterm infants with or at risk for respiratory distress syndrome. Cochrane Database Syst Rev. 2007 Oct 17. CD003063. [QxMD MEDLINE Link].

50. Soll R, Ozek E. Multiple versus single doses of exogenous surfactant for the prevention or treatment of neonatal respiratory distress syndrome. Cochrane Database Syst Rev. 2009 Jan 21. CD000141. [QxMD MEDLINE Link].

51. Pohlandt F, Saule H, Schroder H, et al. Decreased incidence of extra-alveolar air leakage or death prior to air leakage in high versus low rate positive pressure ventilation: results of a randomised seven-centre trial in preterm infants. Eur J Pediatr. 1992 Dec. 151(12):904-9. [QxMD MEDLINE Link].

52. Greenough A, Murthy V, Milner AD, Rossor TE, Sundaresan A. Synchronized mechanical ventilation for respiratory support in newborn infants. Cochrane Database Syst Rev. 2016 Aug 19. CD000456. [QxMD MEDLINE Link].

53. Henderson-Smart DJ, Cools F, Bhuta T, Offringa M. Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants. Cochrane Database Syst Rev. 2007 Jul 18. CD000104. [QxMD MEDLINE Link].

54. Bhuta T, Henderson-Smart DJ. Rescue high frequency oscillatory ventilation versus conventional ventilation for pulmonary dysfunction in preterm infants. Cochrane Database Syst Rev. 2000. (2):CD000438. [QxMD MEDLINE Link].

55. Bhuta T, Henderson-Smart DJ. Elective high frequency jet ventilation versus conventional ventilation for respiratory distress syndrome in preterm infants. Cochrane Database Syst Rev. 2000. (2):CD000328. [QxMD MEDLINE Link].

56. Goel S, Mondkar J, Panchal H, Hegde D, Utture A, Manerkar S. Nasal mask versus nasal prongs for delivering nasal continuous positive airway pressure in preterm infants with respiratory distress: a randomized controlled trial. Indian Pediatr. 2015 Dec. 52(12):1035-40. [QxMD MEDLINE Link].

57. Stefanescu BM, Frewan N, Slaughter JC, O'Shea TM. Volume guarantee pressure support ventilation in extremely preterm infants and neurodevelopmental outcome at 18 months. J Perinatol. 2015 Jun. 35(6):419-23. [QxMD MEDLINE Link].

58. McCallion N, Davis PG, Morley CJ. Volume-targeted versus pressure-limited ventilation in the neonate. Cochrane Database Syst Rev. 2005 Jul 20. CD003666. [QxMD MEDLINE Link].

59. Ng G, da Silva O, Ohlsson A. Bronchodilators for the prevention and treatment of chronic lung disease in preterm infants. Cochrane Database Syst Rev. 2016 Dec 14. 12:CD003214. [QxMD MEDLINE Link].

Abhay J Bhatt, MD, MBBS Professor, Department of Pediatrics, Division of Neonatology, Clinical Science Director, Center for Developmental Disorders Research, University of Mississippi Medical Center

Abhay J Bhatt, MD, MBBS is a member of the following medical societies: Society for Pediatric Research

Disclosure: Nothing to disclose.

Rita M Ryan, MD Chair and Professor, Department of Pediatrics, Medical University of South Carolina College of Medicine; Pediatrician-in-Chief, Division of Neonatology, MUSC Children's Hospital

Rita M Ryan, MD is a member of the following medical societies: American Academy of Pediatrics, American Pediatric Society, American Physiological Society, American Thoracic Society, Irish and American Paediatric Society, Perinatal Research Society, Society for Pediatric Research, Southern Society for Pediatric Research

Disclosure: Nothing to disclose.

Jagdish Desai, MD, MPH Assistant Professor of Pediatrics, Neonatologist, University of Mississippi Medical Center

Jagdish Desai, MD, MPH is a member of the following medical societies: American Academy of Pediatrics, American Association of Physicians of Indian Origin, Brooklyn Pediatric Society, Midwest Society for Pediatric Research

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Brian S Carter, MD, FAAP Professor of Pediatrics, University of Missouri-Kansas City School of Medicine; Attending Physician, Division of Neonatology, Children's Mercy Hospital and Clinics; Faculty, Children's Mercy Bioethics Center

Brian S Carter, MD, FAAP is a member of the following medical societies: Alpha Omega Alpha, American Academy of Hospice and Palliative Medicine, American Academy of Pediatrics, American Pediatric Society, American Society for Bioethics and Humanities, American Society of Law, Medicine & Ethics, Society for Pediatric Research, National Hospice and Palliative Care Organization

Disclosure: Nothing to disclose.

Muhammad Aslam, MD Professor of Pediatrics, University of California, Irvine, School of Medicine; Neonatologist, Division of Newborn Medicine, Department of Pediatrics, UC Irvine Medical Center

Muhammad Aslam, MD is a member of the following medical societies: American Academy of Pediatrics

Disclosure: Nothing to disclose.

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