Transient Tachypnea of the Newborn Clinical Presentation

1. Hooper SB, Siew ML, Kitchen MJ, te Pas AB. Establishing functional residual capacity in the non-breathing infant. Semin Fetal Neonatal Med. 2013 Dec. 18(6):336-43. [QxMD MEDLINE Link].

2. Venkatesh VC, Katzberg HD. Glucocorticoid regulation of epithelial sodium channel genes in human fetal lung. Am J Physiol. 1997 Jul. 273(1 Pt 1):L227-33. [QxMD MEDLINE Link].

3. Hooper SB, Wallace MJ, Harding R. Amiloride blocks the inhibition of fetal lung liquid secretion caused by AVP but not by asphyxia. J Appl Physiol. Jan 1993. 74(1):111-5.

4. Olver RE, Ramsden CA, Strang LB, Walters DV. The role of amiloride-blockable sodium transport in adrenaline-induced lung liquid reabsorption in the fetal lamb. J Physiol. 1986 Jul. 376:321-40. [QxMD MEDLINE Link].

5. Machado LU, Fiori HH, Baldisserotto M, Ramos Garcia PC, Vieira AC, Fiori RM. Surfactant deficiency in transient tachypnea of the newborn. J Pediatr. 2011 Nov. 159(5):750-4. [QxMD MEDLINE Link].

6. Silasi M, Coonrod DV, Kim M, Drachman D. Transient tachypnea of the newborn: is labor prior to cesarean delivery protective?. Am J Perinatol. 2010 Nov. 27(10):797-802. [QxMD MEDLINE Link].

7. Milner AD, Saunders RA, Hopkin IE. Effects of delivery by caesarean section on lung mechanics and lung volume in the human neonate. Arch Dis Child. 1978 Jul. 53(7):545-8. [QxMD MEDLINE Link].

8. Olver RE, Ramsden CA, Strang LB. Adrenaline-induced changes in net lung liquid volume flow across the pulmonary epithelium of the fetal lamb: evidence for active sodium transport. J Physiol. 1981. 319:38-39.

9. Brown MJ, Olver RE, Ramsden CA, Strang LB, Walters DV. Effects of adrenaline and of spontaneous labour on the secretion and absorption of lung liquid in the fetal lamb. J Physiol. 1983 Nov. 344:137-52. [QxMD MEDLINE Link].

10. Demissie K, Marcella SW, Breckenridge MB, Rhoads GG. Maternal asthma and transient tachypnea of the newborn. Pediatrics. 1998 Jul. 102(1 Pt 1):84-90. [QxMD MEDLINE Link].

11. Schatz M, Zeiger RS, Hoffman CP, Saunders BS, Harden KM, Forsythe AB. Increased transient tachypnea of the newborn in infants of asthmatic mothers. Am J Dis Child. 1991 Feb. 145(2):156-8. [QxMD MEDLINE Link].

12. Gundogdu Z. Effect of sibship asthma on newborns with transient tachypnea of the newborn (TTN). Clin Respir J. 2020 Oct 15. [QxMD MEDLINE Link].

13. Derbent A, Tatli MM, Duran M, Tonbul A, Kafali H, Akyol M. Transient tachypnea of the newborn: effects of labor and delivery type in term and preterm pregnancies. Arch Gynecol Obstet. 2011 May. 283(5):947-51. [QxMD MEDLINE Link].

14. Tutdibi E, Gries K, Bücheler M, Misselwitz B, Schlosser RL, Gortner L. Impact of labor on outcomes in transient tachypnea of the newborn: population-based study. Pediatrics. 2010 Mar. 125(3):e577-83. [QxMD MEDLINE Link].

15. Rocha GM, Flor-De-Lima FS, Guimaraes HA. Persistent grunting respirations after birth. Minerva Pediatr. 2018 Jun. 70 (3):217-24. [QxMD MEDLINE Link].

16. Bricelj K, Tul N, Lucovnik M, et al. Neonatal respiratory morbidity in late-preterm births in pregnancies with and without gestational diabetes mellitus. J Matern Fetal Neonatal Med. 2017 Feb. 30 (4):377-9. [QxMD MEDLINE Link].

17. Keszler M, Carbone MT, Cox C, Schumacher RE. Severe respiratory failure after elective repeat cesarean delivery: a potentially preventable condition leading to extracorporeal membrane oxygenation. Pediatrics. 1992 Apr. 89(4 Pt 1):670-2. [QxMD MEDLINE Link].

18. Liem JJ, Huq SI, Ekuma O, Becker AB, Kozyrskyj AL. Transient tachypnea of the newborn may be an early clinical manifestation of wheezing symptoms. J Pediatr. 2007 Jul. 151(1):29-33. [QxMD MEDLINE Link].

19. Birnkrant DJ, Picone C, Markowitz W, El Khwad M, Shen WH, Tafari N. Association of transient tachypnea of the newborn and childhood asthma. Pediatr Pulmonol. 2006 Oct. 41(10):978-84. [QxMD MEDLINE Link].

20. Kasap B, Duman N, Ozer E, Tatli M, Kumral A, Ozkan H. Transient tachypnea of the newborn: predictive factor for prolonged tachypnea. Pediatr Int. 2008 Feb. 50(1):81-4. [QxMD MEDLINE Link].

21. Ozkiraz S, Gokmen Z, Boke SB, Kilicdag H, Ozel D, Sert A. Lactate and lactate dehydrogenase in predicting the severity of transient tachypnea of the newborn. J Matern Fetal Neonatal Med. 2013 Aug. 26(12):1245-8. [QxMD MEDLINE Link].

22. Aydemir O, Aydemir C, Sarikabadayi YU, Altug N, Erdeve O, Uras N. The role of plasma N-terminal pro-B-type natriuretic peptide in predicting the severity of transient tachypnea of the newborn. Early Hum Dev. 2012 May. 88(5):315-9. [QxMD MEDLINE Link].

23. Oztekın O, Kalay S, Tayman C, Namuslu M, Celık HT. Levels of ischemia-modified albumin in transient tachypnea of the newborn. Am J Perinatol. 2015 Feb. 30 (2):193-8. [QxMD MEDLINE Link].

24. Copetti R, Cattarossi L. The 'double lung point': an ultrasound sign diagnostic of transient tachypnea of the newborn. Neonatology. 2007. 91(3):203-9. [QxMD MEDLINE Link].

25. Matsuoka MW, da Rocha SMS, Gibelli MABC, Nicolau CM, de Carvalho WB, Suzuki L. Use of lung ultrasound in neonates during the COVID-19 pandemic. Radiol Bras. 2020 Nov-Dec. 53 (6):401-4. [QxMD MEDLINE Link]. [Full Text].

26. Hein HA, Ely JW, Lofgren MA. Neonatal respiratory distress in the community hospital: when to transport, when to keep. J Fam Pract. 1998 Apr. 46(4):284-9. [QxMD MEDLINE Link].

27. Kao B, Stewart de Ramirez SA, Belfort MB, Hansen A. Inhaled epinephrine for the treatment of transient tachypnea of the newborn. J Perinatol. 2008 Mar. 28(3):205-10. [QxMD MEDLINE Link].

28. Lewis V, Whitelaw A. Furosemide for transient tachypnea of the newborn. Cochrane Database Syst Rev. 2002. (1):CD003064. [QxMD MEDLINE Link].

29. Aslan E, Tutdibi E, Martens S, Han Y, Monz D, Gortner L. Transient tachypnea of the newborn (TTN): a role for polymorphisms in the beta-adrenergic receptor (ADRB) encoding genes?. Acta Paediatr. 2008 Oct. 97(10):1346-50. [QxMD MEDLINE Link].

30. Kim MJ, Yoo JH, Jung JA, Byun SY. The effects of inhaled albuterol in transient tachypnea of the newborn. Allergy Asthma Immunol Res. 2014 Mar. 6(2):126-30. [QxMD MEDLINE Link].

31. Kasap B, Duman N, Ozer E, Tatli M, Kumral A, Ozkan H. Transient tachypnea of the newborn: predictive factor for prolonged tachypnea. Pediatr Int. 2008 Feb. 50(1):81-4. [QxMD MEDLINE Link].

32. Dehdashtian M, Aletayeb M, Malakian A, Aramesh MR, Malvandi H. Clinical course in infants diagnosed with transient tachypnea of newborn: A clinical trial assessing the role of conservative versus conventional management. J Chin Med Assoc. 2018 Feb. 81 (2):183-6. [QxMD MEDLINE Link]. [Full Text].

33. Weintraub AS, Cadet CT, Perez R, DeLorenzo E, Holzman IR, Stroustrup A. Antibiotic use in newborns with transient tachypnea of the newborn. Neonatology. 2013. 103(3):235-40. [QxMD MEDLINE Link].

34. Salama H, Abughalwa M, Taha S, Sharaf N, Mansour A. Transient tachypnea of the newborn: Is empiric antimicrobial therapy needed?. J Neonatal Perinatal Med. 2013. 6(3):237-41. [QxMD MEDLINE Link].

35. Vaisbourd Y, Abu-Raya B, Zangen S, et al. Inhaled corticosteroids in transient tachypnea of the newborn: A randomized, placebo-controlled study. Pediatr Pulmonol. 2017 Aug. 52 (8):1043-50. [QxMD MEDLINE Link].

36. Alkan S, Ozer EA, Ilhan O, Sutcuoglu S, Tatli M. Surfactant treatment for neonatal respiratory disorders other than respiratory distress syndrome. J Matern Fetal Neonatal Med. 2015 Jan. 28 (2):131-3. [QxMD MEDLINE Link].

37. Buchiboyina A, Jasani B, Deshmukh M, Patole S. Strategies for managing transient tachypnoea of the newborn - a systematic review. J Matern Fetal Neonatal Med. 2017 Jul. 30 (13):1524-32. [QxMD MEDLINE Link].

Siva Subramanian, MD, FAAP Emeritus Chief of Neonatal-Perinatal Medicine, Medstar Georgetown University Hospital; Professor Emeritus of Pediatrics and Obstetrics, Senior Ethicist, Pellegrino Center for Clinical Bioethics, Georgetown University Medical Center

Siva Subramanian, MD, FAAP is a member of the following medical societies: American Pediatric Society, American Association for the Advancement of Science, American College of Nutrition, American Pediatric Society, American Society for Parenteral and Enteral Nutrition, Southern Society for Pediatric Research

Disclosure: Nothing to disclose.

Ashish O Gupta, MD Fellow in Neonatal-Perinatal Medicine, Division of Neonatal-Perinatal Medicine, MedStar Georgetown University Hospital

Ashish O Gupta, MD is a member of the following medical societies: American Academy of Pediatrics, American Medical Association, American Association of Physicians of Indian Origin

Disclosure: Nothing to disclose.

Monisha Bahri, MBBS, MD Attending Physician, Department of Neonatalogy, Washington Hospital Center

Monisha Bahri, MBBS, MD is a member of the following medical societies: American Academy of Pediatrics, Medical Council of India, Indian Academy of Pediatrics

Disclosure: Nothing to disclose.

Stephen D Kicklighter, MD Clinical Assistant Professor, Department of Pediatrics, Division of Neonatology, North Carolina State University and Wake Medical Center

Stephen D Kicklighter, MD is a member of the following medical societies: American Academy of Pediatrics, National Perinatal Association

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Brian S Carter, MD, FAAP Professor of Pediatrics, University of Missouri-Kansas City School of Medicine; Attending Physician, Division of Neonatology, Children's Mercy Hospital and Clinics; Faculty, Children's Mercy Bioethics Center

Brian S Carter, MD, FAAP is a member of the following medical societies: Alpha Omega Alpha, American Academy of Hospice and Palliative Medicine, American Academy of Pediatrics, American Pediatric Society, American Society for Bioethics and Humanities, American Society of Law, Medicine & Ethics, Society for Pediatric Research, National Hospice and Palliative Care Organization

Disclosure: Nothing to disclose.

Ted Rosenkrantz, MD Professor, Departments of Pediatrics and Obstetrics/Gynecology, Division of Neonatal-Perinatal Medicine, University of Connecticut School of Medicine

Ted Rosenkrantz, MD is a member of the following medical societies: American Academy of Pediatrics, American Pediatric Society, Eastern Society for Pediatric Research, American Medical Association, Connecticut State Medical Society, Society for Pediatric Research

Disclosure: Nothing to disclose.

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