Acute Poststreptococcal Glomerulonephritis Questions & Answers

1. Avner ED, Davis ID. Acute poststreptococcal glomerulonephritis. Behrman RE, Kliegman RM, Jenson HB, eds. Nelson Textbook of Pediatrics. 17th ed. Philadelphia, Pa: Elsevier Science; 2004. 1740-41.

2. Rodríguez-Iturbe B, Batsford S. Pathogenesis of poststreptococcal glomerulonephritis a century after Clemens von Pirquet. Kidney Int. 2007 Jun. 71(11):1094-104. [QxMD MEDLINE Link].

3. Brant Pinheiro SV, de Freitas VB, de Castro GV, et al. Acute Post-Streptococcal Glomerulonephritis in Children: A Comprehensive Review. Curr Med Chem. 2022. 29 (34):5543-59. [QxMD MEDLINE Link].

4. Hunt EAK, Somers MJG. Infection-Related Glomerulonephritis. Pediatr Clin North Am. 2019 Feb. 66 (1):59-72. [QxMD MEDLINE Link].

5. Blyth CC, Robertson PW, Rosenberg AR. Post-streptococcal glomerulonephritis in Sydney: a 16-year retrospective review. J Paediatr Child Health. 2007 Jun. 43(6):446-50. [QxMD MEDLINE Link].

6. Sanjad S, Tolaymat A, Whitworth J, Levin S. Acute glomerulonephritis in children: a review of 153 cases. South Med J. 1977 Oct. 70(10):1202-6. [QxMD MEDLINE Link].

7. Sagel I, Treser G, Ty A, et al. Occurrence and nature of glomerular lesions after group A streptococci infections in children. Ann Intern Med. 1973 Oct. 79(4):492-9. [QxMD MEDLINE Link].

8. Kimmelstiel P. The hump-a lesion of glomerulonephritis. Bull Pathol. 1965. 6:187.

9. Nissenson AR, Baraff LJ, Fine RN, Knutson DW. Poststreptococcal acute glomerulonephritis: fact and controversy. Ann Intern Med. 1979 Jul. 91(1):76-86. [QxMD MEDLINE Link].

10. Yoshizawa N, Yamakami K, Fujino M, et al. Nephritis-associated plasmin receptor and acute poststreptococcal glomerulonephritis: characterization of the antigen and associated immune response. J Am Soc Nephrol. 2004 Jul. 15(7):1785-93. [QxMD MEDLINE Link].

11. Oda T, Yamakami K, Omasu F, et al. Glomerular plasmin-like activity in relation to nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis. J Am Soc Nephrol. 2005 Jan. 16(1):247-54. [QxMD MEDLINE Link].

12. Poon-King R, Bannan J, Viteri A, Cu G, Zabriskie JB. Identification of an extracellular plasmin binding protein from nephritogenic streptococci. J Exp Med. 1993 Aug 1. 178(2):759-63. [QxMD MEDLINE Link]. [Full Text].

13. Parra G, Rodríguez-Iturbe B, Batsford S, et al. Antibody to streptococcal zymogen in the serum of patients with acute glomerulonephritis: a multicentric study. Kidney Int. 1998 Aug. 54(2):509-17. [QxMD MEDLINE Link].

14. Cu GA, Mezzano S, Bannan JD, Zabriskie JB. Immunohistochemical and serological evidence for the role of streptococcal proteinase in acute post-streptococcal glomerulonephritis. Kidney Int. 1998 Sep. 54(3):819-26. [QxMD MEDLINE Link].

15. García R, Rubio L, Rodríguez-Iturbe B. Long-term prognosis of epidemic poststreptococcal glomerulonephritis in Maracaibo: follow-up studies 11-12 years after the acute episode. Clin Nephrol. 1981 Jun. 15(6):291-8. [QxMD MEDLINE Link].

16. Perlman LV, Herdman RC, Kleinman H, Vernier RL. Poststreptococcal glomerulonephritis. A ten-year follow-up of an epidemic. JAMA. 1965 Oct 4. 194(1):63-70. [QxMD MEDLINE Link].

17. Kandoth PW, Agarwal GJ, Dharnidharka VR. Acute renal failure in children requiring dialysis therapy. Indian Pediatr. 1994 Mar. 31(3):305-9. [QxMD MEDLINE Link].

18. Baldwin DS, Gluck MC, Schacht RG, Gallo G. The long-term course of poststreptococcal glomerulonephritis. Ann Intern Med. 1974 Mar. 80(3):342-58. [QxMD MEDLINE Link].

19. World Health Organization. Countries. Available at http://www.who.int/countries/en/. Accessed: January 10, 2008.

20. Treser G, Semar M, McVicar M, Franklin M, Ty A, Sagel I, et al. Antigenic streptococcal components in acute glomerulonephritis. Science. 1969 Feb 14. 163(868):676-7. [QxMD MEDLINE Link].

21. Balter S, Benin A, Pinto SW, et al. Epidemic nephritis in Nova Serrana, Brazil. Lancet. 2000 May 20. 355(9217):1776-80. [QxMD MEDLINE Link].

22. Francis AJ, Nimmo GR, Efstratiou A, Galanis V, Nuttall N. Investigation of milk-borne Streptococcus zooepidemicus infection associated with glomerulonephritis in Australia. J Infect. 1993 Nov. 27(3):317-23. [QxMD MEDLINE Link].

23. McIntosh RM, Kulvinskas C, Kaufman DB. Alteration of the chemical composition of human immunoglobulin G by Streptococcus pyogenes. J Med Microbiol. 1971 Nov. 4(4):535-8. [QxMD MEDLINE Link].

24. Gewurz H, Pickering RJ, Naff G, Snyderman R, Mergenhagen SE, Good RA. Decreased properdin activity in acute glomerulonephritis. Int Arch Allergy Appl Immunol. 1969. 36(6):592-8. [QxMD MEDLINE Link].

25. Wyatt RJ, Forristal J, West CD, Sugimoto S, Curd JG. Complement profiles in acute post-streptococcal glomerulonephritis. Pediatr Nephrol. 1988 Apr. 2(2):219-23. [QxMD MEDLINE Link].

26. Wyatt RJ, McAdams AJ, Forristal J, Snyder J, West CD. Glomerular deposition of complement-control proteins in acute and chronic glomerulonephritis. Kidney Int. 1979 Oct. 16(4):505-12. [QxMD MEDLINE Link].

27. Hisano S, Matsushita M, Fujita T, Takeshita M, Iwasaki H. Activation of the lectin complement pathway in post-streptococcal acute glomerulonephritis. Pathol Int. 2007 Jun. 57(6):351-7. [QxMD MEDLINE Link].

28. Derrick CW, Reeves MS, Dillon HC Jr. Complement in overt and asymptomatic nephritis after skin infection. J Clin Invest. 1970 Jun. 49(6):1178-87. [QxMD MEDLINE Link]. [Full Text].

29. Levy M, Sich M, Pirotzky E, Habib R. Complement activation in acute glomerulonephritis in children. Int J Pediatr Nephrol. 1985 Jan-Mar. 6(1):17-24. [QxMD MEDLINE Link].

30. Sjöholm AG. Complement components and complement activation in acute poststreptococcal glomerulonephritis. Int Arch Allergy Appl Immunol. 1979. 58(3):274-84. [QxMD MEDLINE Link].

31. Strife CF, McAdams AJ, McEnery PT, Bove KE, West CD. Hypocomplementemic and normocomplementemic acute nephritis in children: a comparison with respect to etiology, clinical manifestations, and glomerular morphology. J Pediatr. 1974 Jan. 84(1):29-38. [QxMD MEDLINE Link].

32. Demircioglu Kılıc B, Akbalık Kara M, Buyukcelik M, Balat A. Pediatric post-streptococcal glomerulonephritis: Clinical and laboratory data. Pediatr Int. 2018 May 5. [QxMD MEDLINE Link].

33. Tina LU, D'Albora JB, Antonovych TT, Bellanti JA, Calcagno PL. Acute glomerulonephritis associated with normal serum B1C-globulin. Am J Dis Child. 1968 Jan. 115(1):29-36. [QxMD MEDLINE Link].

34. West CD, McAdams AJ. Serum and glomerular IgG in poststreptococcal glomerulonephritis are correlated. Pediatr Nephrol. 1998 Jun. 12(5):392-6. [QxMD MEDLINE Link].

35. Eison TM, Ault BH, Jones DP, Chesney RW, Wyatt RJ. Post-streptococcal acute glomerulonephritis in children: clinical features and pathogenesis. Pediatr Nephrol. 2011 Feb. 26(2):165-80. [QxMD MEDLINE Link].

36. Ilyas M, Tolaymat A. Changing epidemiology of acute post-streptococcal glomerulonephritis in Northeast Florida: a comparative study. Pediatr Nephrol. 2008 Jul. 23(7):1101-6. [QxMD MEDLINE Link].

37. Longcope WT, O'Brien DP, McGuire J, Hansen OC, Denny ER. Relationship of acute infections to glomerular nephritis. J Clin Invest. 1927 Dec. 5(1):7-30. [QxMD MEDLINE Link]. [Full Text].

38. Dixon FJ, Feldman JD, Vazquez JJ. Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J Exp Med. 1961 May 1. 113:899-920. [QxMD MEDLINE Link]. [Full Text].

39. Wong W, Lennon DR, Crone S, Neutze JM, Reed PW. Prospective population-based study on the burden of disease from post-streptococcal glomerulonephritis of hospitalised children in New Zealand: epidemiology, clinical features and complications. J Paediatr Child Health. 2013 Oct. 49(10):850-5. [QxMD MEDLINE Link].

40. Chong HC, Hung TY, Hohls A, Francis JR, Chaturvedi S. Clinical characteristics of hospitalised children with acute post-streptococcal glomerulonephritis in the Top End of Australia. J Paediatr Child Health. 2023 May. 59 (5):735-42. [QxMD MEDLINE Link].

41. Dowler J, Wilson A. Acute post-streptococcal glomerulonephritis in Central Australia. Aust J Rural Health. 2020 Feb. 28 (1):74-80. [QxMD MEDLINE Link].

42. Wu SH, Liao PY, Yin PL, Zhang YM, Dong L. Elevated expressions of 15-lipoxygenase and lipoxin A4 in children with acute poststreptococcal glomerulonephritis. Am J Pathol. 2009 Jan. 174(1):115-22. [QxMD MEDLINE Link]. [Full Text].

43. Lange K, Azadegan AA, Seligson G, Bovie RC, Majeed H. Asymptomatic poststreptococcal glomerulonephritis in relatives of patients with symptomatic glomerulonephritis. Diagnostic value of endostreptosin antibodies. Child Nephrol Urol. 1988-1989. 9(1-2):11-5. [QxMD MEDLINE Link].

44. Seligson G, Lange K, Majeed HA, Deol H, Cronin W, Bovie R. Significance of endostreptosin antibody titers in poststreptococcal glomerulonephritis. Clin Nephrol. 1985 Aug. 24(2):69-75. [QxMD MEDLINE Link].

45. Limm-Chan B, Musgrave J, Lau R, Ahn HJ, Nguyen L, Kurahara D. Incidence of Acute Post-Streptococcal Glomerulonephritis in Hawai'i and Factors Affecting Length of Hospitalization. Hawaii J Health Soc Welf. 2020 May 1. 79 (5):149-52. [QxMD MEDLINE Link]. [Full Text].

46. Rodriguez-Iturbe B, Musser JM. The current state of poststreptococcal glomerulonephritis. J Am Soc Nephrol. 2008 Oct. 19(10):1855-64. [QxMD MEDLINE Link].

47. Greenbaum LA, Kerlin BA, Van Why S, Punzalan RC, Trost BA, Pan CG, et al. Concurrent poststreptococcal glomerulonephritis and autoimmune hemolytic anemia. Pediatr Nephrol. 2003 Dec. 18(12):1301-3. [QxMD MEDLINE Link].

48. Lau KK, Hastings MC, Delos Santos NM, Gaber LW, Ault BH. A child with post-streptococcal glomerulonephritis complicated by Coombs positive autoimmune haemolytic anemia. Internet J Nephro. 2007.

49. Haas M, Racusen LC, Bagnasco SM. IgA-dominant postinfectious glomerulonephritis: a report of 13 cases with common ultrastructural features. Hum Pathol. 2008 Sep. 39(9):1309-16. [QxMD MEDLINE Link].

50. Pais PJ, Kump T, Greenbaum LA. Delay in diagnosis in poststreptococcal glomerulonephritis. J Pediatr. 2008 Oct. 153(4):560-4. [QxMD MEDLINE Link].

51. Ayoob RM, Schwaderer AL. Acute Kidney Injury and Atypical Features during Pediatric Poststreptococcal Glomerulonephritis. Int J Nephrol. 2016. 2016:5163065. [QxMD MEDLINE Link]. [Full Text].

52. Tokura T, Morita Y, Yorimitsu D, Horike H, Sasaki T, Kashihara N. Co-occurrence of poststreptococcal reactive arthritis and acute glomerulonephritis. Mod Rheumatol. 2008. 18(5):526-8. [QxMD MEDLINE Link].

53. Lewy JE, Salinas-Madrigal L, Herdson PB, Pirani CL, Metcoff J. Clinico-pathologic correlations in acute poststreptococcal glomerulonephritis. A correlation between renal functions, morphologic damage and clinical course of 46 children with acute poststreptococcal glomerulonephritis. Medicine (Baltimore). 1971 Nov. 50(6):453-501. [QxMD MEDLINE Link].

54. Dodge WF, Spargo BH, Travis LB, et al. Poststreptococcal glomerulonephritis. A prospective study in children. N Engl J Med. 1972 Feb 10. 286(6):273-8. [QxMD MEDLINE Link].

55. Sarkissian A, Papazian M, Azatian G, Arikiants N, Babloyan A, Leumann E. An epidemic of acute postinfectious glomerulonephritis in Armenia. Arch Dis Child. 1997 Oct. 77(4):342-4. [QxMD MEDLINE Link]. [Full Text].

56. Bingler MA, Ellis D, Moritz ML. Acute post-streptococcal glomerulonephritis in a 14-month-old boy: why is this uncommon?. Pediatr Nephrol. 2007 Mar. 22(3):448-50. [QxMD MEDLINE Link].

57. Li Volti S, Furnari ML, Garozzo R, Santangelo G, Mollica F. Acute post-streptococcal glomerulonephritis in an 8-month-old girl. Pediatr Nephrol. 1993 Dec. 7(6):737-8. [QxMD MEDLINE Link].

58. Burke EC, Titus JL. Poststreptococcal acute glomerulonephritis in children. Med Clin North Am. 1966 Jul. 50(4):1141-58. [QxMD MEDLINE Link].

59. Travis LB, Dodge WF, Beathard GA, Spargo BH, Lorentz WB, Carvajal HF, et al. Acute glomerulonephritis in children. A review of the natural history with emphasis on prognosis. Clin Nephrol. 1973 May-Jun. 1(3):169-81. [QxMD MEDLINE Link].

60. Rodríguez-Iturbe B. Epidemic poststreptococcal glomerulonephritis. Kidney Int. 1984 Jan. 25(1):129-36. [QxMD MEDLINE Link].

61. Bouhard BH, Travis LB. Acute postinfectious glomerulonephritis. Eldeman CM, Ed. Pediatric Kidney Disease. 2nd ed. Boston, Mass: Little, Brown and Company; 1992. 1199-1221.

62. Choyke PL, Bluth EI, Bush WH Jr, et al, and the Expert Panel on Urologic Imaging. ACR Appropriateness Criteria: hematuria. [online publication]. Reston,Va: American College of Radiology (ACR); 2005.

63. Jennings RB, Earle DP. Post-streptococcal glomerulo-nephritis: histopathologic and clinical studies of the acute, subsiding acute and early chronic latent phases. J Clin Invest. 1961 Aug. 40:1525-95. [QxMD MEDLINE Link]. [Full Text].

64. Anand SK, Trygstad CW, Sharma HM, Northway JD. Extracapillary proliferative glomerulonephritis in children. Pediatrics. 1975 Sep. 56(3):434-42. [QxMD MEDLINE Link].

65. Roy S 3rd, Murphy WM, Arant BS Jr. Poststreptococcal crescenteric glomerulonephritis in children: comparison of quintuple therapy versus supportive care. J Pediatr. 1981 Mar. 98(3):403-10. [QxMD MEDLINE Link].

66. Wong W, Morris MC, Zwi J. Outcome of severe acute post-streptococcal glomerulonephritis in New Zealand children. Pediatr Nephrol. 2009 May. 24(5):1021-6. [QxMD MEDLINE Link].

67. Fish AJ, Herdman RC, Michael AF, Pickering RJ, Good RA. Epidemic acute glomerulonephritis associated with type 49 streptococcal pyoderma. II. Correlative study of light, immunofluorescent and electron microscopic findings. Am J Med. 1970 Jan. 48(1):28-39. [QxMD MEDLINE Link].

68. McCluskey RT, Vassalli P, Gallo G, Baldwin DS. An immunofluorescent study of pathogenic mechanisms in glomerular diseases. N Engl J Med. 1966 Mar 31. 274(13):695-701. [QxMD MEDLINE Link].

69. Yoshizawa N. Acute glomerulonephritis. Intern Med. 2000 Sep. 39(9):687-94. [QxMD MEDLINE Link].

70. Dale JB, Penfound T, Chiang EY, Long V, Shulman ST, Beall B. Multivalent group A streptococcal vaccine elicits bactericidal antibodies against variant M subtypes. Clin Diagn Lab Immunol. 2005 Jul. 12(7):833-6. [QxMD MEDLINE Link]. [Full Text].

71. Carapetis JR, Steer AC, Mulholland EK, Weber M. The global burden of group A streptococcal diseases. Lancet Infect Dis. 2005 Nov. 5(11):685-94. [QxMD MEDLINE Link].

72. Shank JC, Powell TA. A five-year experience with throat cultures. J Fam Pract. 1984 Jun. 18(6):857-63. [QxMD MEDLINE Link].

73. Centor RM, Witherspoon JM, Dalton HP, Brody CE, Link K. The diagnosis of strep throat in adults in the emergency room. Med Decis Making. 1981. 1(3):239-46. [QxMD MEDLINE Link].

74. McIsaac WJ, White D, Tannenbaum D, Low DE. A clinical score to reduce unnecessary antibiotic use in patients with sore throat. CMAJ. 1998 Jan 13. 158(1):75-83. [QxMD MEDLINE Link]. [Full Text].

75. Edmonson MB, Farwell KR. Relationship between the clinical likelihood of group a streptococcal pharyngitis and the sensitivity of a rapid antigen-detection test in a pediatric practice. Pediatrics. 2005 Feb. 115(2):280-5. [QxMD MEDLINE Link].

76. American Academy of Pediatrics, Committee in Infectious Diseases. Group A streptococcal infections. The Red Book. Elk Grove Village, Ill: American Academy of Pediatrics; 2000. 526-92.

Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal) Associate Professor of Pediatrics, Principal Specialist, Department of Pediatrics and Child Health, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, South Africa

Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal) is a member of the following medical societies: African Association of Nephrology, American Association for the Advancement of Science, International Pediatric Nephrology Association, International Society of Nephrology, National Kidney Foundation, South African Medical Association, South African Paediatric Association, South African Renal Society

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

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Adrian Spitzer, MD Clinical Professor Emeritus, Department of Pediatrics, Albert Einstein College of Medicine

Adrian Spitzer, MD is a member of the following medical societies: American Academy of Pediatrics, American Federation for Medical Research, American Pediatric Society, American Society of Nephrology, American Society of Pediatric Nephrology, International Society of Nephrology, Society for Pediatric Research

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Craig B Langman, MD Tenured Professor of Pediatrics, The First Isaac A Abt, MD, Professor of Kidney Diseases (Emeritus), Northwestern University, The Feinberg School of Medicine; Staff Nephrologist, The Ann and Robert H Lurie Children’s Hospital of Chicago

Craig B Langman, MD is a member of the following medical societies: American Academy of Pediatrics, American Federation for Clinical Research, American Society for Bone and Mineral Research, American Society of Nephrology, American Society of Pediatric Nephrology, Association of Clinical Scientists, Cochrane Collaboration, International Bone and Mineral Society, International Conferences on Calcium Regulating Hormones, International Pediatric Nephrology Association, International Society of Nephrology, International Society of Renal Nutrition and Metabolism, Midwest Society for Pediatric Research, Pediatric Academic Societies, ROCK (Research on Calculus Kinetics) Society, Society for Pediatric Research

Disclosure: Received income in an amount equal to or greater than $250 from: Alexion Pharmaceuticals; Horizon Pharmaceuticals); Dicerna Pharmaceuticals<br/>Incyte Pharmaceuticals; Eli Lilly for: Federation bio; Dicerna pharmaceuticals.

Richard Neiberger, MD, PhD Director of Pediatric Renal Stone Disease Clinic, Associate Professor, Department of Pediatrics, Division of Nephrology, University of Florida College of Medicine and Shands Hospital

Richard Neiberger, MD, PhD is a member of the following medical societies: American Academy of Pediatrics, American Federation for Medical Research, American Medical Association, American Society of Nephrology, American Society of Pediatric Nephrology, Christian Medical and Dental Associations, Florida Medical Association, International Society for Peritoneal Dialysis, International Society of Nephrology, National Kidney Foundation, New York Academy of Sciences, Shock Society, Sigma Xi, The Scientific Research Honor Society, Southern Medical Association, Southern Society for Pediatric Research, Southwest Pediatric Nephrology Study Group

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Yang Sun Kim MD, Assistant Professor, Department of Pediatrics, Division of Neonatology, New York University Medical Center; Clinical Director, Neonatology Intensive Care Unit, Bellevue Hospital

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Robert G Schacht, MD, Professor, Vice-Chair of Pediatrics, Department of Pediatrics, Division of Nephrology, New York University Medical Center.

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Luther Travis, MD Professor Emeritus, Departments of Pediatrics, Nephrology and Diabetes, University of Texas Medical Branch School of Medicine

Luther Travis, MD is a member of the following medical societies: Alpha Omega Alpha, American Federation for Medical Research, International Society of Nephrology, and Texas Pediatric Society

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