Adipsia Differential Diagnoses

Updated: Oct 03, 2023
  • Author: Vikas R Dharnidharka, MD, MPH; Chief Editor: Craig B Langman, MD  more...
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Diagnostic Considerations

An important variant of primary hypodipsia is the syndrome of essential hypernatremia. An impaired osmotic regulation of aqueous vasopressin (AVP) and thirst characterizes essential hypernatremia; however, AVP synthesis and secretion is intact in response to hemodynamic stimuli. Patients may present with mild stable elevations of serum sodium concentration, consistent with the upward regulation of the osmostats, or with severe fluctuations in serum sodium concentration, consistent with complete loss of osmoregulatory function.

Differential Diagnoses