Adipsia Medication

1. Eisenberg Y, Frohman LA. ADIPSIC DIABETES INSIPIDUS: A REVIEW. Endocr Pract. 2016 Jan. 22 (1):76-83. [QxMD MEDLINE Link].

2. Verbalis JG, Berl T. Disorders of water balance. Brenner BM. The Kidney. 8. WB Saunders; 2007. 8.

3. Sinha A, Ball S, Jenkins A, Hale J, Cheetham T. Objective assessment of thirst recovery in patients with adipsic diabetes insipidus. Pituitary. 2011 Dec. 14(4):307-11. [QxMD MEDLINE Link].

4. Arima H, Wakabayashi T, Nagatani T, Fujii M, Hirakawa A, Murase T. Adipsia increases risk of death in patients with central diabetes insipidus. Endocr J. 2014. 61(2):143-8. [QxMD MEDLINE Link].

5. Pal GK, Pal P, Raj SS, Mohan M. Modulation of feeding and drinking behaviour by catecholamines injected into nucleus caudatus in rats. Indian J Physiol Pharmacol. 2001 Apr. 45(2):172-80. [QxMD MEDLINE Link].

6. Kang JH, Chang D, Lee YW, Na KJ, Yang MP. Adipsic hypernatremia in a dog with antithyroid antibodies in cerebrospinal fluid and serum. J Vet Med Sci. 2007 Jul. 69(7):751-4. [QxMD MEDLINE Link].

7. Weiland TJ, Voudouris NJ, Kent S. CCK(2) receptor nullification attenuates lipopolysaccharide-induced sickness behavior. Am J Physiol Regul Integr Comp Physiol. 2007 Jan. 292(1):R112-23. [QxMD MEDLINE Link].

8. Damm J, Harden LM, Gerstberger R, Roth J, Rummel C. The putative JAK-STAT inhibitor AG490 exacerbates LPS-fever, reduces sickness behavior, and alters the expression of pro- and anti-inflammatory genes in the rat brain. Neuropharmacology. 2013 Aug. 71:98-111. [QxMD MEDLINE Link].

9. Blank MS, Farnsworth PB. Idiopathic symptomatic hypernatremia in a 9-year-old boy: a clinical and physiologic evaluation. J Pediatr. 1974 Aug. 85(2):215-9. [QxMD MEDLINE Link].

10. Conley SB, Brocklebank JT, Taylor IT, Robson AM. Recurrent hypernatremia; a proposed mechanism in a patient with absence of thirst and abnormal excretion of water. J Pediatr. 1976 Dec. 89(6):898-903. [QxMD MEDLINE Link].

11. Hayek A, Peake GT. Hypothalamic adipsia without demonstrable structural lesion. Pediatrics. 1982 Aug. 70(2):275-8. [QxMD MEDLINE Link].

12. Mavrakis AN, Tritos NA. Diabetes insipidus with deficient thirst: report of a patient and review of the literature. Am J Kidney Dis. 2008 May. 51(5):851-9. [QxMD MEDLINE Link].

13. Cuesta M, Hannon MJ, Thompson CJ. Adipsic diabetes insipidus in adult patients. Pituitary. 2017 Jun. 20 (3):372-380. [QxMD MEDLINE Link].

14. Lopez-Capape M, Golmayo L, Lorenzo G, et al. Hypothalamic adipic hypernatraemia syndrome with normal osmoregulation of vasopressin. Eur J Pediatr. 2004 Oct. 163(10):580-3. [QxMD MEDLINE Link].

15. [Guideline] Mentes JC. Hydration management. Iowa City (IA): University of Iowa Gerontological Nursing Interventions Research Center, Research Dissemination Core; 2004 Feb. [Full Text].

16. Arima H, Azuma Y, Morishita Y, Hagiwara D. Central diabetes insipidus. Nagoya J Med Sci. 2016 Dec. 78 (4):349-358. [QxMD MEDLINE Link]. [Full Text].

17. Booth JD, Josse RG, Singer W. Pituitary and hypothalamic dysfunction in a patient with a basal encephalocele. J Endocrinol Invest. 1983 Dec. 6(6):473-8. [QxMD MEDLINE Link].

18. Bradley WG, Price DL. Adipsia in association with an arachnoid cyst. Neurology. 1971 Sep. 21(9):930-6. [QxMD MEDLINE Link].

19. Christie SB, Ross EJ. Ectopic pinealoma with adipsia and hypernatraemia. Br Med J. 1968 Jun 15. 2(606):669-70. [QxMD MEDLINE Link].

20. DeRubertis FR, Michelis MF, Davis BB. "Essential" hypernatremia. Report of three cases and review of the literature. Arch Intern Med. 1974 Nov. 134(5):889-95. [QxMD MEDLINE Link].

21. Grossman SP, Dacey D, Halaris AE, et al. Aphagia and adipsia after preferential destruction of nerve cell bodies in hypothalamus. Science. 1978 Nov 3. 202(4367):537-9. [QxMD MEDLINE Link].

22. Jeffery ND, Watson PJ, Abramson C, Notenboom A. Brain malformations associated with primary adipsia identified usingmagnetic resonance imaging. Vet Rec. 2003 Apr 5. 152(14):436-8. [QxMD MEDLINE Link].

23. Johnson AK, Buggy J. Periventricular preoptic-hypothalamus is vital for thirst and normal water economy. Am J Physiol. 1978 Mar. 234(3):R122-9. [QxMD MEDLINE Link].

24. Johnston S, Burgess J, McMillan T, Greenwood R. Management of adipsia by a behavioural modification technique. J Neurol Neurosurg Psychiatry. 1991 Mar. 54(3):272-4. [QxMD MEDLINE Link].

25. Lopez-Capape M, Golmayo L, Lorenzo G, Gallego N, Barrio R. Hypothalamic adipic hypernatraemia syndrome with normal osmoregulation of vasopressin. Eur J Pediatr. 2004 Oct. 163(10):580-3. [QxMD MEDLINE Link].

26. Macias Batista A, Martinez Martin FJ, de Pablos Velasco PL. [Diabetes insipidus and adipsic hypernatremia in a patient with a craniopharyngioma]. An Med Interna. 1999 Feb. 16:87-8. [QxMD MEDLINE Link].

27. Mackay BM, Curtis N. Adipsia and hypernatraemia in a dog with focal hypothalamic granulomatous meningoencephalitis. Aust Vet J. 1999 Jan. 77(1):14-7. [QxMD MEDLINE Link].

28. Papadimitriou A, Kipourou K, Manta C, et al. Adipsic hypernatremia syndrome in infancy. J Pediatr Endocrinol Metab. 1997 Sep-Oct. 10(5):547-50. [QxMD MEDLINE Link].

29. Phillips MG, Gabow PA. Psychogenic adipsia in a patient with psychotic depression. Am J Kidney Dis. 1990 Jun. 15(6):592-4. [QxMD MEDLINE Link].

30. Poll-The BT, Aicardi J. Pseudomonoventricle due to a malformation of the septum pellucidum. Neuropediatrics. 1985 Feb. 16(1):39-42. [QxMD MEDLINE Link].

31. Robertson GL. Abnormalities of thirst regulation. Kidney Int. 1984 Feb. 25(2):460-9. [QxMD MEDLINE Link].

32. Ronconi GF, Ronconi M, Stella M, et al. [Neurogenic hypernatremia with adipsia and cerebral malformations in a child with ectrodactyly-ectodermal dysplasia-cleft lip-palate syndrome]. Pediatr Med Chir. 1985 Nov-Dec. 7(6):893-7. [QxMD MEDLINE Link].

33. Schaad U, Vassella F, Zuppinger K, Oetliker O. Hypodipsia-hypernatremia syndrome. Helv Paediatr Acta. 1979 Feb. 34(1):63-76. [QxMD MEDLINE Link].

34. Schallert T. Adipsia produced by lateral hypothalamic lesions: facilitation of recovery by preoperative restriction of water intake. J Comp Physiol Psychol. 1982 Aug. 96(4):604-14. [QxMD MEDLINE Link].

35. Silver BV, Stelly-Seitz C. Behavioral treatment of adipsia in a child with hypothalamic injury. Dev Med Child Neurol. 1992 Jun. 34(6):539-42. [QxMD MEDLINE Link].

36. Sklar CA, Grumbach MM, Kaplan SL, Conte FA. Hormonal and metabolic abnormalities associated with central nervous system germinoma in children and adolescents and the effect of therapy: report of 10 patients. J Clin Endocrinol Metab. 1981 Jan. 52(1):9-16. [QxMD MEDLINE Link].

37. Spiro SG, Jenkins JS. Adipsia and hypothermia after subarachnoid hemorrhage. Br Med J. 1971 Aug 14. 3(771):411-2. [QxMD MEDLINE Link].

38. Travis LB, Dodge WF, Waggener JD, Kashemsant C. Defective thirst mechanism secondary to a hypothalamic lesion: studies in a child with adipsia, polyphagia, obesity, and persistent hyperosmolality. J Pediatr. 1967 Jun. 70(6):915-26. [QxMD MEDLINE Link].

39. Verdin E, Smitz S, Thibaut A, et al. Adipsic hypernatremia in a patient with pseudotumor cerebri and the primary empty sella syndrome. J Endocrinol Invest. 1985 Aug. 8(4):369-72. [QxMD MEDLINE Link].

40. Villadsen AB, Pedersen EB. Recumbent cranial diabetes insipidus. Studies in a patient with adipsia, hypernatremia, poikilothermia and polyphagia. Acta Paediatr Scand. 1987 Jan. 76(1):179-83. [QxMD MEDLINE Link].

41. Yamamoto T, Shimizu M, Fukuyama J, Yamaji T. Pathogenesis of extracellular fluid abnormalities of hypothalamic hypodipsia-hypernatremia syndrome. Endocrinol Jpn. 1988 Dec. 35(6):915-24. [QxMD MEDLINE Link].

42. Crowley RK, Sherlock M, Agha A, Smith D, Thompson CJ. Clinical insights into adipsic diabetes insipidus: a large case series. Clin Endocrinol (Oxf). 2007 Apr. 66(4):475-82. [QxMD MEDLINE Link].

Vikas R Dharnidharka, MD, MPH Professor and Chief, Division of Pediatric Nephrology, Hypertension and Pheresis, Vice-Chair for Clinical Investigation, Department of Pediatrics, St Louis Children's Hospital, Washington University in St Louis School of Medicine

Vikas R Dharnidharka, MD, MPH is a member of the following medical societies: American Academy of Pediatrics, American Society of Nephrology, American Society of Pediatric Nephrology, American Society of Transplantation

Disclosure: Received research grant from: CareDx<br/>Received consulting fee from Atara Biotherapeutics for: Received consulting fee from Transplant Genomics.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Adrian Spitzer, MD Clinical Professor Emeritus, Department of Pediatrics, Albert Einstein College of Medicine

Adrian Spitzer, MD is a member of the following medical societies: American Academy of Pediatrics, American Federation for Medical Research, American Pediatric Society, American Society of Nephrology, American Society of Pediatric Nephrology, International Society of Nephrology, Society for Pediatric Research

Disclosure: Nothing to disclose.

Craig B Langman, MD Tenured Professor of Pediatrics, The First Isaac A Abt, MD, Professor of Kidney Diseases (Emeritus), Northwestern University, The Feinberg School of Medicine; Staff Nephrologist, The Ann and Robert H Lurie Children’s Hospital of Chicago

Craig B Langman, MD is a member of the following medical societies: American Academy of Pediatrics, American Federation for Clinical Research, American Society for Bone and Mineral Research, American Society of Nephrology, American Society of Pediatric Nephrology, Association of Clinical Scientists, Cochrane Collaboration, International Bone and Mineral Society, International Conferences on Calcium Regulating Hormones, International Pediatric Nephrology Association, International Society of Nephrology, International Society of Renal Nutrition and Metabolism, Midwest Society for Pediatric Research, Pediatric Academic Societies, ROCK (Research on Calculus Kinetics) Society, Society for Pediatric Research

Disclosure: Received income in an amount equal to or greater than $250 from: Alexion Pharmaceuticals; Horizon Pharmaceuticals); ; Dicerna Pharmaceuticals<br/>Incyte Pharmaceuticals; Eli Lilly for: Federation bio; Dicerna pharmaceuticals.

Uri S Alon, MD Director of Bone and Mineral Disorders Clinic and Renal Research Laboratory, Children's Mercy Hospital of Kansas City; Professor, Department of Pediatrics, Division of Pediatric Nephrology, University of Missouri-Kansas City School of Medicine

Uri S Alon, MD is a member of the following medical societies: American Federation for Medical Research

Disclosure: Nothing to disclose.

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