Anti-GBM Antibody Disease Medication

Updated: Dec 19, 2019
  • Author: Agnieszka Swiatecka-Urban, MD, FASN, FAAP; Chief Editor: Craig B Langman, MD  more...
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Medication

Medication Summary

The treatment of choice is a combination of plasmapheresis to remove circulating anti-glomerular basement membrane (GBM) antibodies and immunosuppression with glucocorticoids and cytotoxic agents to inhibit further autoantibody formation.

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Glucocorticoids

Class Summary

These agents are used as adjuncts to plasmapheresis to minimize antibody formation. Glucocorticoids have anti-inflammatory properties and cause profound and varied metabolic effects. They modify the body's immune response to diverse stimuli.

Methylprednisolone (Medrol, Solu-Medrol)

DOC. Should be started concomitantly with plasmapheresis.

Prednisone (Deltasone, Orasone, Liquid Pred)

Administer after methylprednisolone pulses and continue for 6-12 mo, depending on response and adverse effects.

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Immunosuppressive agents

Class Summary

Immunosuppressants are used as adjuncts to plasmapheresis and glucocorticoids to minimize new antibody formation. Therapy is continued for 6-12 months, the time usually required to stop the formation of anti-GBM antibodies.

Cyclophosphamide (Cytoxan, Neosar)

DOC because of long-standing use in adults and children.

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