Pediatric Nephrotic Syndrome Differential Diagnoses

Updated: Oct 24, 2018
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Diagnostic Considerations

Acute kidney failure (AKF) is a rare complication of idiopathic nephrotic syndrome. Fever, rash, arthralgia and eosinophilia with a "bland" urinalysis (minimal cellular elements) in the presence of AKF are typical for acute interstitial nephritis. However, obvious clinical symptoms may be absent except for the AKF and unremarkable urinalysis. Gross hematuria, flank pain, and thrombocytopenia may be signs of renal vein thrombosis. Hemoconcentration in the patient with anasarca might indicate intravascular volume depletion.

Differential Diagnoses