Stamatelou K, Goldfarb DS. Epidemiology of Kidney Stones. Healthcare (Basel). 2023 Feb 2. 11 (3):[QxMD MEDLINE Link]. [Full Text].
Torricelli FC, De S, Liu X, Calle J, Gebreselassie S, Monga M. Can 24-hour urine stone risk profiles predict urinary stone composition?. J Endourol. 2014 Jun. 28 (6):735-8. [QxMD MEDLINE Link].
Baldree LA, Stapleton FB. Uric acid metabolism in children. Pediatr Clin North Am. 1990 Apr. 37(2):391-418. [QxMD MEDLINE Link].
Fujita T, Shimooka T, Teraoka Y, Sugita Y, Kaito H, Iijima K, et al. Acute renal failure due to obstructive uric acid stones associated with acute gastroenteritis. Pediatr Nephrol. 2009 Dec. 24(12):2467-9. [QxMD MEDLINE Link].
Kaneko K, Shimo T, Hirabayashi M, Ito T, Okazaki H, Harada Y. Cause of uric acid stones in rotavirus-associated gastroenteritis. Pediatr Nephrol. 2010 Oct. 25(10):2187-8. [QxMD MEDLINE Link].
Cao B, Daniel R, McGregor R, Tasian GE. Pediatric Nephrolithiasis. Healthcare (Basel). 2023 Feb 13. 11 (4):[QxMD MEDLINE Link]. [Full Text].
Tasian GE, Copelovitch L. Evaluation and medical management of kidney stones in children. J Urol. 2014 Nov. 192 (5):1329-36. [QxMD MEDLINE Link].
Rizvi SA, Sultan S, Zafar MN, Ahmed B, Aba Umer S, Naqvi SA. Paediatric urolithiasis in emerging economies. Int J Surg. 2016 Dec. 36 (Pt D):705-712. [QxMD MEDLINE Link].
Kato K, Sai S, Hirata T, et al. Two cases of ammonium acid urate urinary stones related to anorexia nervosa and laxative abuse. Hinyokika Kiyo.Mar. 2004. 50(3):181-5. [QxMD MEDLINE Link].
Madani A, Kermani N, Ataei N, Esfahani ST, Hajizadeh N, Khazaeipour Z. Urinary calcium and uric acid excretion in children with vesicoureteral reflux. Pediatr Nephrol. 2012 Jan. 27(1):95-9. [QxMD MEDLINE Link].
Leng S, Shiung M, Ai S, Qu M, Vrtiska TJ, Grant KL, et al. Feasibility of discriminating uric acid from non-uric acid renal stones using consecutive spatially registered low- and high-energy scans obtained on a conventional CT scanner. AJR Am J Roentgenol. 2015 Jan. 204 (1):92-7. [QxMD MEDLINE Link]. [Full Text].
Ganesan V, De S, Shkumat N, Marchini G, Monga M. Accurately Diagnosing Uric Acid Stones from Conventional Computerized Tomography Imaging: Development and Preliminary Assessment of a Pixel Mapping Software. J Urol. 2018 Feb. 199 (2):487-494. [QxMD MEDLINE Link].
McGrath TA, Frank RA, Schieda N, et al. Diagnostic accuracy of dual-energy computed tomography (DECT) to differentiate uric acid from non-uric acid calculi: systematic review and meta-analysis. Eur Radiol. 2020 May. 30 (5):2791-801. [QxMD MEDLINE Link].
Ong A, Brown G, Tokas T, Hameed BMZ, Philip J, Somani BK. Selection and Outcomes for Dissolution Therapy in Uric Acid Stones: A Systematic Review of Literature. Curr Urol Rep. 2023 Aug. 24 (8):355-63. [QxMD MEDLINE Link].
Nevo A, Humphreys MR, Callegari M, et al. Is medical dissolution treatment for uric acid stones more cost-effective than surgical treatment? A novel, solo practice, retrospective cost-analysis of medical vs. surgical therapy. Can Urol Assoc J. 2023 Jan. 17 (1):E29-E34. [QxMD MEDLINE Link]. [Full Text].
Oh MM, Ham BK, Kang SH, Bae JH, Kim JJ, Yoo KH, et al. Urine alkalinization may be enough for the treatment of bilateral renal pelvis stones associated with Lesch-Nyhan syndrome. Urol Res. 2011 Oct. 39(5):417-9. [QxMD MEDLINE Link].

Table 1. Serum Uric Acid levels and Urinary Acid Excretion in Neonates, Children, and Adults^[3]

Table 1. Serum Uric Acid levels and Urinary Acid Excretion in Neonates, Children, and Adults ^[3]

	Neonates*			Children						Adults
	29-33 wk	34-37 wk	38-40 wk	3-4 y		5-9 y		10-14 y		40-44 y
				Male	Female	Male	Female	Male	Female	Male	Female
Serum uric acid (mg/dL)	7.71±2.65	6.04±2.19	5.19±1.57	3.45±1.01	3.44±0.8	3.63±1.04	3.71±0.92	4.28±1.19	4.09±1.2	5.134±1.25	4.25±1.1
Uric acid excretion (mg/dL GFR^†)	4.8±2.23	2.81±0.93	1.69±0.84	0.34±0.11						0.403±0.095
Uric acid excretion (mg/kg/d)	N/A	N/A	19.6	13.5±3.75 (3 y)		11.5±3.75 (7 y)		9±3.75 (12 y)		10
Fractional excretion of uric acid (%)	61.24±12.21	44.52±15.23	38.19±13.61	12±3.75 (3 y)		10±3 (7 y)		7.6±3.75 (12 y)		7±1.6
*Gestational ages ^† Glomerular filtration rate

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Author

Sahar Fathallah-Shaykh, MD Professor of Pediatrics, University of Alabama at Birmingham School of Medicine; Medical Director of Pediatric Dialysis Unit, Division of Pediatric Nephrology, Children's of Alabama

Sahar Fathallah-Shaykh, MD is a member of the following medical societies: American Society of Nephrology, American Society of Pediatric Nephrology

Disclosure: Nothing to disclose.

Coauthor(s)

Richard Neiberger, MD, PhD Director of Pediatric Renal Stone Disease Clinic, Associate Professor, Department of Pediatrics, Division of Nephrology, University of Florida College of Medicine and Shands Hospital

Richard Neiberger, MD, PhD is a member of the following medical societies: American Academy of Pediatrics, American Federation for Medical Research, American Medical Association, American Society of Nephrology, American Society of Pediatric Nephrology, Christian Medical and Dental Associations, Florida Medical Association, International Society for Peritoneal Dialysis, International Society of Nephrology, National Kidney Foundation, New York Academy of Sciences, Shock Society, Sigma Xi, The Scientific Research Honor Society, Southern Medical Association, Southern Society for Pediatric Research, Southwest Pediatric Nephrology Study Group

Disclosure: Nothing to disclose.

Specialty Editor Board

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Frederick J Kaskel, MD, PhD Director of the Division and Training Program in Pediatric Nephrology, Vice Chair, Department of Pediatrics, Montefiore Medical Center and Albert Einstein School of Medicine

Frederick J Kaskel, MD, PhD is a member of the following medical societies: American Association for the Advancement of Science, Eastern Society for Pediatric Research, Renal Physicians Association, American Academy of Pediatrics, American Pediatric Society, American Physiological Society, American Society of Nephrology, American Society of Pediatric Nephrology, American Society of Transplantation, Federation of American Societies for Experimental Biology, International Society of Nephrology, National Kidney Foundation, New York Academy of Sciences, Sigma Xi, The Scientific Research Honor Society, Society for Pediatric Research

Disclosure: Nothing to disclose.

Chief Editor

Craig B Langman, MD Tenured Professor of Pediatrics, The First Isaac A Abt, MD, Professor of Kidney Diseases (Emeritus), Northwestern University, The Feinberg School of Medicine; Staff Nephrologist, The Ann and Robert H Lurie Children’s Hospital of Chicago

Craig B Langman, MD is a member of the following medical societies: American Academy of Pediatrics, American Federation for Clinical Research, American Society for Bone and Mineral Research, American Society of Nephrology, American Society of Pediatric Nephrology, Association of Clinical Scientists, Cochrane Collaboration, International Bone and Mineral Society, International Conferences on Calcium Regulating Hormones, International Pediatric Nephrology Association, International Society of Nephrology, International Society of Renal Nutrition and Metabolism, Midwest Society for Pediatric Research, Pediatric Academic Societies, ROCK (Research on Calculus Kinetics) Society, Society for Pediatric Research

Disclosure: Received income in an amount equal to or greater than $250 from: Alexion Pharmaceuticals; Horizon Pharmaceuticals); ; Dicerna Pharmaceuticals<br/>Incyte Pharmaceuticals; Eli Lilly for: Federation bio; Dicerna pharmaceuticals.

Additional Contributors

Uri S Alon, MD Director of Bone and Mineral Disorders Clinic and Renal Research Laboratory, Children's Mercy Hospital of Kansas City; Professor, Department of Pediatrics, Division of Pediatric Nephrology, University of Missouri-Kansas City School of Medicine

Uri S Alon, MD is a member of the following medical societies: American Federation for Medical Research

Disclosure: Nothing to disclose.

Uric Acid Stones Clinical Presentation

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Uric Acid Stones Clinical Presentation

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