Henoch-Schonlein Purpura (IgA Vasculitis) Questions & Answers

Updated: Oct 28, 2020
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Questions & Answers

Overview

What is Henoch-Schönlein purpura (IgA vasculitis)?

What are the signs and symptoms of Henoch-Schönlein purpura (IgA vasculitis)?

What are physical findings characteristic of Henoch-Schönlein purpura (IgA vasculitis)?

What are the diagnostic criteria for Henoch-Schönlein purpura (IgA vasculitis)?

What is the role of lab tests in the diagnosis of Henoch-Schönlein purpura (IgA vasculitis)?

What is the role of imaging in the diagnosis of Henoch-Schönlein purpura (IgA vasculitis)?

Which procedures may be warranted in the diagnosis of Henoch-Schönlein purpura (IgA vasculitis)?

What are treatment options for Henoch-Schönlein purpura (IgA vasculitis)?

Which analgesics may be used for the treatment of Henoch-Schönlein purpura (IgA vasculitis)?

When are corticosteroids indicated for the treatment of Henoch-Schönlein purpura (IgA vasculitis)?

Which medications may be used for the treatment of Henoch-Schönlein purpura (IgA vasculitis)?

What is the role of surgery in the treatment of Henoch-Schönlein purpura (IgA vasculitis)?

How is Henoch-Schönlein purpura (IgA vasculitis) characterized?

Which individuals are at highest risk for Henoch-Schönlein purpura (IgA vasculitis)?

What are the clinical features of Henoch-Schönlein purpura (IgA vasculitis)?

What is the pathophysiology of Henoch-Schönlein purpura (IgA vasculitis)?

What is the role of interleukins (ILs) and growth factors in the pathophysiology of Henoch-Schönlein purpura (IgA vasculitis)?

What is the role of cytokines in the pathophysiology of Henoch-Schönlein purpura (IgA vasculitis)?

What is the role of genetics in the pathophysiology of Henoch-Schönlein purpura (IgA vasculitis)?

What is the role of nitric oxide (NO) production in the pathophysiology of Henoch-Schönlein purpura (IgA vasculitis)?

What is the presentation of Henoch-Schönlein purpura (IgA vasculitis) that is montelukast-related?

Which hypercoagulability markers are elevated in Henoch-Schönlein purpura (IgA vasculitis)?

What are the commonalities between IgA nephropathy in Henoch-Schönlein purpura (IgA vasculitis)?

What evidence supports Henoch-Schönlein purpura (IgA vasculitis) and IgA nephropathy as distinct disorders?

What causes Henoch-Schönlein purpura (IgA vasculitis)?

Which infections may have an etiologic role in the development of Henoch-Schönlein purpura (IgA vasculitis)?

What vaccinations may trigger the development of Henoch-Schönlein purpura (IgA vasculitis)?

What environmental exposures may trigger the development of Henoch-Schönlein purpura (IgA vasculitis)?

What is the prevalence of Henoch-Schönlein purpura (IgA vasculitis) in the US?

What is the global prevalence of Henoch-Schönlein purpura (IgA vasculitis)?

How does the prevalence of Henoch-Schönlein purpura (IgA vasculitis)?

How does the incidence of Henoch-Schönlein purpura (IgA vasculitis) vary by sex?

What are the racial predilections for Henoch-Schönlein purpura (IgA vasculitis)?

What is the prognosis of Henoch-Schönlein purpura (IgA vasculitis)?

Which patient groups typically have complete resolution of Henoch-Schönlein purpura (IgA vasculitis)?

How frequent are recurrences of Henoch-Schönlein purpura (IgA vasculitis)?

What are possible complications of Henoch-Schönlein purpura (IgA vasculitis)?

What is the primary cause of mortality in individuals with Henoch-Schönlein purpura (IgA vasculitis)?

What are predictors of nephropathy in Henoch-Schönlein purpura (IgA vasculitis)?

What are health risks for pregnant women with a childhood history of Henoch-Schönlein purpura (IgA vasculitis)?

Which factors may impact the long-term prognosis for Henoch-Schönlein purpura (IgA vasculitis)?

What is included in patient education for Henoch-Schönlein purpura (IgA vasculitis)?

Presentation

What is the prodrome of Henoch-Schönlein purpura (IgA vasculitis)?

What symptoms develop after the prodrome of Henoch-Schönlein purpura (IgA vasculitis)?

How is rash characterized in Henoch-Schönlein purpura (IgA vasculitis)?

What are GI symptoms of Henoch-Schönlein purpura (IgA vasculitis)?

How is arthralgia characterized in Henoch-Schönlein purpura (IgA vasculitis)?

What are the symptoms of acute hemorrhagic edema of infancy (AHEI) in Henoch-Schönlein purpura (IgA vasculitis)?

What are skin manifestations of Henoch-Schönlein purpura (IgA vasculitis) in infants?

What are genitourinary symptoms of Henoch-Schönlein purpura (IgA vasculitis)?

What are the neurological symptoms of Henoch-Schönlein purpura (IgA vasculitis)?

What are the biliary and renal symptoms of Henoch-Schönlein purpura (IgA vasculitis)?

What is the recurrence rate for Henoch-Schönlein purpura (IgA vasculitis)?

Why is a complete physical exam required for evaluation of Henoch-Schönlein purpura (IgA vasculitis)?

Which dermatologic findings are characteristic of Henoch-Schönlein purpura (IgA vasculitis)?

Which renal findings are characteristic of Henoch-Schönlein purpura (IgA vasculitis)?

Which GI findings are characteristic of Henoch-Schönlein purpura (IgA vasculitis)?

Which joint findings are characteristic of Henoch-Schönlein purpura (IgA vasculitis)?

What are vascular and hematologic findings suggestive of Henoch-Schönlein purpura (IgA vasculitis)?

In what organ system are Henoch-Schönlein purpura (IgA vasculitis) complications found?

What are potential complications of Henoch-Schönlein purpura (IgA vasculitis)?

DDX

Which conditions should be included in the differential diagnoses of Henoch-Schönlein purpura (IgA vasculitis)?

What are the differential diagnoses for Henoch-Schonlein Purpura (IgA Vasculitis)?

Workup

How is Henoch-Schönlein purpura (IgA vasculitis) diagnosed?

What is the role of lab tests in the workup of Henoch-Schönlein purpura (IgA vasculitis)?

Which findings from serial urine samples suggest Henoch-Schönlein purpura (IgA vasculitis)?

Which lab findings predict progression risk in Henoch-Schönlein purpura (IgA vasculitis)?

What is the role of ultrasonography in the workup of Henoch-Schönlein purpura (IgA vasculitis)?

What is the role of radiography in the workup of Henoch-Schönlein purpura (IgA vasculitis)?

What is the role of MRI in the workup of Henoch-Schönlein purpura (IgA vasculitis)?

What is the role of CT scanning in the workup of Henoch-Schönlein purpura (IgA vasculitis)?

What is the role of endoscopy in the workup of Henoch-Schönlein purpura (IgA vasculitis)?

What is the role of renal biopsy in the workup of Henoch-Schönlein purpura (IgA vasculitis)?

Which histologic findings are characteristic of Henoch-Schönlein purpura (IgA vasculitis)?

What is the specific renal pathology of Henoch-Schönlein purpura (IgA vasculitis)?

Treatment

What are treatment options for Henoch-Schönlein purpura (IgA vasculitis)?

What is included in supportive management of Henoch-Schönlein purpura (IgA vasculitis)?

What is the role of analgesics in the management of Henoch-Schönlein purpura (IgA vasculitis)?

What is the role of corticosteroids in the management of Henoch-Schönlein purpura (IgA vasculitis)?

How are corticosteroids dosed for the treatment of Henoch-Schönlein purpura (IgA vasculitis)?

What are the treatment options for renal disease due to Henoch-Schönlein purpura (IgA vasculitis)?

Which corticosteroid protocols are used in the treatment of severe Henoch-Schönlein purpura (IgA vasculitis)?

Which drugs may be added to steroid therapy for the treatment of Henoch-Schönlein purpura (IgA vasculitis)?

What is the efficacy of drug treatment for Henoch-Schönlein purpura (IgA vasculitis)?

What are the KDIGO treatment recommendations for Henoch-Schönlein purpura (IgA vasculitis)?

What is the role of plasmapheresis in the treatment of Henoch-Schönlein purpura (IgA vasculitis)?

What is the role of surgery in the treatment of Henoch-Schönlein purpura (IgA vasculitis)?

Which specialist consultations may be helpful in the treatment of Henoch-Schönlein purpura (IgA vasculitis)?

What is included in the long-term monitoring of Henoch-Schönlein purpura (IgA vasculitis)?

Medications

Which medications are used in the treatment of Henoch-Schönlein purpura (HSP)?

Which medications in the drug class Analgesic Agents are used in the treatment of Henoch-Schonlein Purpura (IgA Vasculitis)?

Which medications in the drug class Immunosuppressants are used in the treatment of Henoch-Schonlein Purpura (IgA Vasculitis)?