Biotin Deficiency Differential Diagnoses

Updated: Oct 22, 2018
  • Author: Gratias Tom Mundakel, MBBS, DCH; Chief Editor: Jatinder Bhatia, MBBS, FAAP  more...
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Diagnostic Considerations

The differential diagnosis includes inborn errors of metabolism that present with organic aciduria, metabolic acidosis or hyperammonemia. Skin manifestations of biotin deficiency may mimic those seen with zinc deficiency or essential fatty acid deficiency. Seizures, developmental delay, optic atrophy, sensorineural deafness, ataxia, and paresis may present secondary to various disorders affecting the nervous system. Fungal infections may occur with other conditions causing immunodeficiency. 

Differential Diagnoses