Biotin Deficiency Medication

Updated: Oct 22, 2018
  • Author: Gratias Tom Mundakel, MBBS, DCH; Chief Editor: Jatinder Bhatia, MBBS, FAAP  more...
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Medication

Medication Summary

Biotin is available as 1mg, 3mg, 5 mg and 10 mg oral capsules or tablets. The recommended dosage for biotinidase deficiency is 5-20mg per day. Biotin is also available in supplements containing combinations of other B vitamins or multivitamins. The dosage of biotin in these supplements are often much higher than the recommended adequate intakes. However, toxicity from biotin even when taken in high dosage (up to 200 mg/day) has not been reported. However high intakes of biotin may be associated with clinically important interference with certain lab tests leading to inappropriate medical care. [1, 12]

FDA Biotin Safety Alert November 2017

High intakes of biotin may occur in individuals taking biotin supplements and this may lead to interference with certain diagnostic assays. False negative, as well as false positive results, have been reported for thyroid hormone, TSH, and serum troponin. The FDA is advising health care providers to ask patients if they are on biotin containing supplements and to consider biotin interference as a possible source of error if test results do not correlate with the patient's clinical presentation.  

Drug Interactions: As mentioned elsewhere, chronic therapy with certain anticonvulsants ( phenobarbital, phenytoin, primidone and carbamazepine) may put patients at risk for biotin deficiency. Chronic antibiotic usage may also interfere with biotin production by intestinal flora.

Lipoic acid, often used as a dietary supplement, competes with biotin for the biotin transporter and may lead to decreased levels of some of the carboxylase enzymes. [3]