Pediatric Osteoporosis Differential Diagnoses

Updated: May 25, 2016
  • Author: Manasa Mantravadi, MD, MS; Chief Editor: Jatinder Bhatia, MBBS, FAAP  more...
  • Print
DDx

Diagnostic Considerations

In children, low BMD can be the result of inadequate bone formation or excessive bone resorption.

The following conditions are associated with reduced bone formation:

  • Immobilization or prolonged bed rest
  • Medications: especially corticosteroids, diuretics and cyclosporine
  • Burn injury [23, 24]
  • Hepatic osteodystrophy with chronic cholestasis
  • Aluminum toxicity in association with total parental nutrition (TPN) or renal osteodystrophy
  • Prolonged TPN use

Conditions associated with high bone resorption in children include the following:

  • Corticosteroid-induced bone loss, acute
  • Immobilization or bed rest
  • Juvenile Paget’s
  • Primary and secondary hyperparathyroidism
  • Rickets due to vitamin D, calcium, or phosphorus deficiency
  • Idiopathic juvenile osteoporosis

Conditions associated with low BMD for age and gender without known etiology include the following:

Go to Osteoporosis for complete information on non pediatric osteoporosis.