Pediatric Osteoporosis Differential Diagnoses

Updated: May 24, 2016
  • Author: Manasa Mantravadi, MD, MS; Chief Editor: Jatinder Bhatia, MBBS, FAAP  more...
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DDx

Diagnostic Considerations

In children, low BMD can be the result of inadequate bone formation or excessive bone resorption.

The following conditions are associated with reduced bone formation:

  • Immobilization or prolonged bed rest

  • Medications: especially corticosteroids, diuretics and cyclosporine
  • Burn injury [23, 24]

  • Hepatic osteodystrophy with chronic cholestasis

  • Aluminum toxicity in association with total parental nutrition (TPN) or renal osteodystrophy

  • Prolonged TPN use

Conditions associated with high bone resorption in children include the following:

  • Corticosteroid-induced bone loss, acute

  • Immobilization or bed rest

  • Juvenile Paget’s
  • Primary and secondary hyperparathyroidism

  • Rickets due to vitamin D, calcium, or phosphorus deficiency
  • Idiopathic juvenile osteoporosis

Conditions associated with low BMD for age and gender without known etiology include the following:

Go to Osteoporosis for complete information on non pediatric osteoporosis.