Pediatric Osteoporosis Differential Diagnoses

Updated: May 19, 2020
  • Author: Manasa Mantravadi, MD, MS; Chief Editor: Jatinder Bhatia, MBBS, FAAP  more...
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Diagnostic Considerations

In children, low bone mineral density (BMD) can be the result of inadequate bone formation or excessive bone resorption.

The following conditions are associated with reduced bone formation:

  • Immobilization or prolonged bed rest

  • Medications, especially corticosteroids, diuretics, and cyclosporine
  • Burn injury [25, 26]

  • Hepatic osteodystrophy with chronic cholestasis

  • Aluminum toxicity in association with total parental nutrition (TPN) or renal osteodystrophy

  • Prolonged TPN use

Conditions associated with high bone resorption in children include the following:

Conditions associated with low BMD for age and gender without known etiology include the following:

See Osteoporosis for complete information on non-pediatric osteoporosis.