Pediatric Craniopharyngioma Medication

Updated: Feb 28, 2019
  • Author: Sara R Kreimer Barron, MD; Chief Editor: Vikramjit S Kanwar, MBBS, MBA, MRCP(UK)  more...
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Medication Summary

Drug therapy currently is not usually a component of standard care for craniopharyngioma. However, altered CNS hormone regulation may result following treatment with surgery and radiation, requiring long-term hormonal therapy. Endocrinologic consultation is recommended.


Chemotherapeutic agents

Class Summary

Immunostimulatory therapies with interferon and intracystic/intratumoral injection of chemotherapeutic agents (eg, bleomycin) are occasionally used in cases of recurrent disease.

Bleomycin (Blenoxane)

Peptide antibiotic that acts to inhibit DNA, RNA, and protein synthesis through the induction of DNA strand breaks.

Peginterferon alfa-2b (PEG Intron, PegIntron Redipen, Sylatron)

Naturally occurring interferon alpha is normally secreted by B cells and T cells in response to viral or bacterial infection. The manufactured form (ie, interferon alpha) is a protein product manufactured using recombinant DNA technology. Mechanism of antitumor activity is not clearly understood; however, direct antiproliferative effects against malignant cells and modulation of host immune response may play important roles.