Pediatric Acute Myelocytic Leukemia Questions & Answers

Updated: Sep 12, 2017
  • Author: Mark E Weinblatt, MD; Chief Editor: Jennifer Reikes Willert, MD  more...
  • Print
Questions & Answers

Overview

How is pediatric acute myelocytic leukemia (AML) characterized?

What are the signs and symptoms of pediatric acute myelocytic leukemia (AML) due to a deficiency of normally functioning cells?

What are the signs and symptoms of pediatric acute myelocytic leukemia (AML) due to infiltrative disease?

How is pediatric acute myelocytic leukemia (AML) classified?

Which lab tests are performed in the workup of pediatric acute myelocytic leukemia (AML)?

Which immunophenotyping analyses are performed in the workup of pediatric acute myelocytic leukemia (AML)?

Which imaging studies are performed in the workup of pediatric acute myelocytic leukemia (AML)?

Which clinical procedures are performed in the workup of pediatric acute myelocytic leukemia (AML)?

What are the goals of treatment for pediatric acute myelocytic leukemia (AML)?

Which medications are used in the treatment of pediatric acute myelocytic leukemia (AML)?

What are the nonpharmacologic treatments for pediatric acute myelocytic leukemia (AML)?

Which surgical procedures may be performed in the treatment of pediatric acute myelocytic leukemia (AML)?

What is pediatric acute myelocytic leukemia (AML)?

What is the French-American-British classification system of pediatric acute myelocytic leukemia (AML)?

What is the WHO classification system of pediatric acute myelocytic leukemia (AML)?

What are the immediate and short-term complications of pediatric acute myelocytic leukemia (AML)?

What are the long-term or delayed complications of pediatric acute myelocytic leukemia (AML)?

How does infection affect the prognosis of pediatric acute myelocytic leukemia (AML)?

How does bleeding affect the prognosis of pediatric acute myelocytic leukemia (AML)?

What are the signs and symptoms of tumor lysis syndrome in pediatric acute myelocytic leukemia (AML)?

What are adverse effects of chemotherapy in pediatric acute myelocytic leukemia (AML)?

What are the CNS complications of pediatric acute myelocytic leukemia (AML)?

What causes pediatric acute myelocytic leukemia (AML)?

What is the role of radiation exposure in the etiology of pediatric acute myelocytic leukemia (AML)?

What is the role of exposure to toxins and drugs in the etiology of pediatric acute myelocytic leukemia (AML)?

What is the role of genetics in the etiology of pediatric acute myelocytic leukemia (AML)?

What is the prevalence of pediatric acute myelocytic leukemia (AML) in the US?

What is the global prevalence of pediatric acute myelocytic leukemia (AML)?

How does the incidence of pediatric acute myelocytic leukemia (AML) vary by geographic region?

What are the racial predilections of pediatric acute myelocytic leukemia (AML)?

What are the sexual predilections of pediatric acute myelocytic leukemia (AML)?

Which age groups have the highest prevalence of acute myelocytic leukemia (AML)?

What is the prognosis of pediatric acute myelocytic leukemia (AML)?

How do cytogenetic abnormalities affect the prognosis of pediatric acute myelocytic leukemia (AML)?

Which genetic mutations affect the prognosis of pediatric acute myelocytic leukemia (AML)?

What is included in patient education about pediatric acute myelocytic leukemia (AML)?

Presentation

How can the signs and symptoms of pediatric acute myelocytic leukemia (AML) be categorized?

Which clinical history findings related to deficiency of normally functioning cells suggest pediatric acute myelocytic leukemia (AML)?

Which clinical history findings related to infiltrative disease suggest pediatric acute myelocytic leukemia (AML)?

What are the constitutional signs and symptoms of pediatric acute myelocytic leukemia (AML)?

Which physical findings are characteristic of pancytopenia in pediatric acute myelocytic leukemia (AML)?

Which physical findings are characteristic of leukemic infiltration and proliferation in pediatric acute myelocytic leukemia (AML)?

DDX

What are persistent nonspecific symptoms of pediatric acute myelocytic leukemia (AML)?

Which conditions are included in the differential diagnoses of pediatric acute myelocytic leukemia (AML)?

What are the differential diagnoses for Pediatric Acute Myelocytic Leukemia?

Workup

How is pediatric acute myelocytic leukemia (AML) diagnosed?

What is the role of blood counts and blood smears in the workup of pediatric acute myelocytic leukemia (AML)?

What is the role of blood chemistries and other blood work in the workup of pediatric acute myelocytic leukemia (AML)?

What is the role of radiography in the workup of pediatric acute myelocytic leukemia (AML)?

What is the role of CT scanning and MRI in the workup of pediatric acute myelocytic leukemia (AML)?

What is the role of ultrasonography in the workup of pediatric acute myelocytic leukemia (AML)?

What is the role of radionuclide imaging in the workup of pediatric acute myelocytic leukemia (AML)?

What is the role of histochemical staining in the workup of pediatric acute myelocytic leukemia (AML)?

What is the role of immunophenotyping in the workup of pediatric acute myelocytic leukemia (AML)?

What is the role of cytogenetics in the workup of pediatric acute myelocytic leukemia (AML)?

What is the role of human leukocyte antigen (HLA) typing in the workup of pediatric acute myelocytic leukemia (AML)?

What is the role of bone marrow exam in the workup of pediatric acute myelocytic leukemia (AML)?

Which histologic findings are characteristic of pediatric acute myelocytic leukemia (AML)?

What is the role of lumbar puncture and CSF analysis in the workup of pediatric acute myelocytic leukemia (AML)?

Treatment

How is pediatric acute myelocytic leukemia (AML) treated?

When is patient transfer indicated for the treatment of pediatric acute myelocytic leukemia (AML)?

What is the role of a central venous catheter in pediatric acute myelocytic leukemia (AML) treatment?

What is the role of chemotherapy in pediatric acute myelocytic leukemia (AML) treatment?

What is the role of postinduction therapy in pediatric acute myelocytic leukemia (AML) treatment?

How is acute promyelocytic leukemia (APL) treated?

How is acute myelocytic leukemia (AML) treated in children with Down syndrome?

What is the role of radiation therapy in pediatric acute myelocytic leukemia (AML) treatment?

What is the role of blood and marrow transplantation in pediatric acute myelocytic leukemia (AML) treatment?

What is included in transfusion support for pediatric acute myelocytic leukemia (AML)?

What is included in metabolic management of pediatric acute myelocytic leukemia (AML)?

What is the role of antibiotic therapy in pediatric acute myelocytic leukemia (AML) treatment?

What is the role of antibiotic prophylaxis in pediatric acute myelocytic leukemia (AML) treatment?

What is the role of biologic-response modifiers in the treatment of pediatric acute myelocytic leukemia (AML)?

What is the role of surgery in the treatment of pediatric acute myelocytic leukemia (AML)?

Which dietary modifications are used in the treatment of pediatric acute myelocytic leukemia (AML) treatment?

Which activity modifications are used in the treatment of pediatric acute myelocytic leukemia (AML)?

How is pediatric acute myelocytic leukemia (AML) prevented?

What is included in monitoring and follow-up for pediatric acute myelocytic leukemia (AML)?

Which specialist consultations are beneficial to patients with pediatric acute myelocytic leukemia (AML)?

Medications

What medications are used in pediatric acute myelocytic leukemia (AML) treatment?

Which medications in the drug class Antifungals are used in the treatment of Pediatric Acute Myelocytic Leukemia?

Which medications in the drug class Antimicrobials, prophylactic are used in the treatment of Pediatric Acute Myelocytic Leukemia?

Which medications in the drug class Antiemetic agents are used in the treatment of Pediatric Acute Myelocytic Leukemia?

Which medications in the drug class Chemotherapeutic agents are used in the treatment of Pediatric Acute Myelocytic Leukemia?